A case of a borderline adrenal oncocytoma in a 62-year old female

Behaeghe, Olivia; Geurde, Bernard; Jourdan, J; Bodson, Céline; Seydel, Benoît; Lacremans, Daniel

doi:10.1080/00015458.2020.1846942

Cited by 1 publication

(1 citation statement)

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“…Adrenocortical oncocytic neoplasms (AONs) are exceptionally rare tumors. Differently from the previously described analysis-where only about 160 cases have been reported in the literature-we have identified 287 AON cases [36]. AONs were located in the adrenal cortex, with only one case reported by Chisté M. et al within the adrenal medulla [37].…”

Section: Discussionmentioning

confidence: 58%

Prognosis of Adrenal Oncocytic Neoplasms (AONs): Literature Review of 287 Cases and Presentation of the Oldest Patient

Coppola Bottazzi,

Gambardella,

Mongardini

et al. 2023

JCM

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Introduction: The adrenocortical oncocytic neoplasms (AONs) are rare tumors of the adrenal gland, classified as oncocytoma (AO), oncocytic neoplasm of uncertain malignant potential (AONUMP) and oncocytic carcinoma (AOC). The aim of this study was to perform a review of the literature, in order to evaluate the prognosis of these rare cancers. We also reported the oldest patient with AON. Methods: A comprehensive literature review using as key words “adrenal oncocytoma”, “adrenal oncocytic neoplasm”, and “adrenal oncocytic carcinoma” was performed. Report of the case: We report the case of an 88-year-old woman receiving a left open adrenalectomy for an AON (15 × 10 × 8 cm). The considerable size and weight together with the presence of necrosis were indicative for a lesion with an uncertain potential for malignancy, according to Weiss modified criteria. After two years, the patient was free from any sign of recurrence. Results: Only 287 AONs were detected in the scientific literature, exploring OVID, MEDLINE, PubMed and SCOPUS as dataset. These tumors are usually incidentalomas with an unpredictable malignant potential. Surgical resection remains the mainstay of treatment for AON. Conclusion: AO and AONUMP have an excellent prognosis and a low mortality rate, with only three cases of recurrence reported in the literature and one metastatic case four years after first adrenal surgery. In contrast, AOC carries a high risk of local relapses, distant metastasis, and a significantly higher mortality rate (30%). Surgical resection remains the primary treatment for adrenal oncocytic neoplasms.

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Section: Discussionmentioning

confidence: 58%