A Case for Safety of Cyclamate and Cyclamate-Saccharin Combinations

The effects of low-calorie sweeteners on energy intake and body weight: a systematic review and meta-analyses of sustained intervention studies

“…(1) LCS vs sugar Included Studies. A total of 51 studies compared LCS with sugar: 37 parallel-groups studies [21][22][23][24][25][26][28][29][30][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] (one of these 21 was partly reported earlier in 59 ) and 14 cross-over studies [60][61][62][63][64][65][66][67][68] .…”

“…Children were participants in 11 studies 41,45,49,64 , and adults were participants in 40 studies [21][22][23][24]26,[28][29][30][42][43][44]46,[50][51][52][53][54][55][56][57][58][59][60][61][62][63][65][66][67][68] . In 13 studies, all the participants were people with overweight and/or obesity.…”

“…24,26 Five articles reported research on exclusively female participants 26,[28][29][30]55 , and one article reported research on exclusively male participants 66 . All other articles included both female and male participants (or gender was not specified 46,47 ), with results reported separately for females and males in three articles 54,58,65 . In 33 studies the LCS vs sugar intervention involved beverages only [21][22][23][24][28][29][30]41,[42][43][44][45][46]48,50,52,[55][56][57][58]60,65,67,68 , and in 18 studies it involved beverages and foods 26,49,51,53,54,[61][62][63][64]66 .…”

Scientific Opinion on the substantiation of health claims related to sugar free chewing gum and dental and oral health, including gum and tooth protection and strength (ID 1149), plaque acid neutralisation (ID 1150), maintenance of tooth mineralisation (I

“…Studies cited in the petition from The Calorie Control Council evaluated effects of polyols and synthetic sweetening agents used in sugar-free products on weight maintenance as part of a complete diet-and-exercise programme (Berryman et al, 1968;Kanders et al, 1988Kanders et al, , 1996Blackburn et al, 1997;Morris et al, 1989;Tordoff and Alleva, 1990;Raben et al, 2002). However, sugar-free chewing gum was not directly tested in any of the cited studies.…”

Ciclamato de sódio e rim fetal

“…27 Zöllner e Pieper, 28 estudando pacientes com doenças crônicas renais e hepáticas que receberam doses diárias de ciclamato de sódio (dois ou cinco g) por mais de três anos, verificaram, por meio de monitorização de variáveis bioquímicas e resultados de uroanálise, que não havia qualquer efeito negativo na função renal desses pacientes.…”