A case for glucosamine

Hussain, Mehboob A.

doi:10.1530/eje.0.1390472

Cited by 13 publications

(9 citation statements)

References 51 publications

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“…3 However, there are concerns that it might adversely affect the glucose metabolism and causes insulin resistance, but this has only been proven in animal studies. 4 Recent studies suggest that it may also affect the glucose transport and insulin resistance in humans, especially among patients with impaired glucose tolerance. [5][6][7] However, all these studies had considerable heterogeneity in terms of dose, route and duration of glucosamine administration.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Prolonged Glucosamine Usage on HbA1c Levels and New-Onset Diabetes Mellitus in Overweight and Obese Middle-Aged Women

Gommans

Runhaar

Jacobs

et al. 2017

The American Journal of Medicine

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Section: Introductionmentioning

confidence: 99%

The Effect of Prolonged Glucosamine Usage on HbA1c Levels and New-Onset Diabetes Mellitus in Overweight and Obese Middle-Aged Women

Gommans

Runhaar

Jacobs

et al. 2017

The American Journal of Medicine

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“…Further, O-GlcNAc, serving as a metabolic sensor, may be modulating the expression, activity, localization and/or secretion of proteins. There have been several other molecules and mechanisms proposed as nutrient sensors [4,[7][8][9][10][11], and it is likely that cells use multiple sensors and mechanisms to regulate such an important process as energy homeostasis. Deciphering how these sensors are mediating their effects is an important goal if we are to understand the pathophysiology of complex pleiotropic metabolic diseases, such as type 2 diabetes.…”

Section: Future Directionsmentioning

confidence: 99%

A role for N -acetylglucosamine as a nutrient sensor and mediator of insulin resistance

Wells

Vosseller

Hart

2003

Cellular and Molecular Life Sciences (CMLS)

189

153

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The ability to regulate energy balance at both the cellular and whole body level is an essential process of life. As western society has shifted to a higher caloric diet and more sedentary lifestyle, the incidence of type 2 diabetes (non-insulin-dependent diabetes mellitus) has increased to epidemic proportions. Thus, type 2 diabetes has been described as a disease of 'chronic overnutrition'. There are abundant data to support the relationship between nutrient availability and insulin action. However, there have been multiple hypotheses and debates as to the mechanism by which nutrient availability modulates insulin signaling and how excess nutrients lead to insulin resistance. One well-established pathway for nutrient sensing is the hexosamine biosynthetic pathway (HSP), which produces the acetylated aminosugar nucleotide uridine 5'-diphospho-N-acetylglucosamine (UDP-Glc-NAc) as its end product. Since UDP-GlcNAc is the donor substrate for modification of nucleocytoplasmic proteins at serine and threonine residues with N-acetylglucosamine (O-GlcNAc), the possibility of this posttranslational modification serving as the nutrient sensor has been proposed. We have recently directly tested this model in adipocytes by examining the effect of elevated levels of O-GlcNAc on insulin-stimulated glucose uptake. In this review, we summarize the existing work that implicates the HSP and O-GlcNAc modification as nutrient sensors and regulators of insulin signaling.

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“…This has been proven in several animal based studies. 9 More recent studies suggest that it may also affect the glucose transport and insulin resistance in humans, especially when impaired glucose tolerance is present. [10][11][12] However, these studies differed in terms of the route of administration, duration as well as dosage of glucosamine.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Glucosamine With or Without Chondroitin Sulphate on Glucose Monitoring Parameters in Humans – A Systematic Review

Menon¹,

Hashim²,

Zainal³

et al. 2021

JYP

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Musculoskeletal diseases that included OA was the second greatest contributor to disability as measured by years lived with disability. The goals of OA treatment are to reduce pain, improve function and quality of life and decrease disability. The objective of this systematic review is to summarise the findings of the effect of glucosamine with or without chondroitin sulphate on glucose monitoring parameters in humans. An English language literature search of electronic bibliographic databases such as Medline, Web of Science, Science Direct, Scopus and Cochrane since inception to June 2020 was conducted. Two reviewers independently analysed the studies for quality and content using the Downs and Black Checklist. The thirteen studies that were included in the review consists of randomised control trials (n=7), non-randomised control trials (n=3), prospective cohort studies (n=2) and pre-post studies (n=1). Five studies detected the effect of glucosamine on glucose parameters. Studies that recruited patients with baseline impaired glucose tolerance or insulin resistance were more likely to detect an effect on glucose metabolism. Patients taking glucosamine have a higher risk of diabetes especially those who have high baseline glucose levels or have diabetes or have impaired glucose tolerance. Only two studies investigated the effect of glucosamine on glucose parameters in patients having osteoarthritis.

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A case for glucosamine

Cited by 13 publications

References 51 publications

The Effect of Prolonged Glucosamine Usage on HbA1c Levels and New-Onset Diabetes Mellitus in Overweight and Obese Middle-Aged Women

The Effect of Prolonged Glucosamine Usage on HbA1c Levels and New-Onset Diabetes Mellitus in Overweight and Obese Middle-Aged Women

A role for N -acetylglucosamine as a nutrient sensor and mediator of insulin resistance

The Effect of Glucosamine With or Without Chondroitin Sulphate on Glucose Monitoring Parameters in Humans – A Systematic Review

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