A Case-Controlled Study of the Oncologic Safety of Fat Grafting

Gale, Katherine; Rakha, Emad A.; Ball, Graham; Tan, Veronique Kiak Mien; McCulley, Stephen J.; Macmillan, R.D.

doi:10.1097/prs.0000000000001151

Cited by 109 publications

(68 citation statements)

References 62 publications

(125 reference statements)

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“…(8) Gale suggested that early fat transfer (≤2 years) after tumor resection may increase the impact of fat transfer on recurrence rates. (54) Kronowitz et al - who also support the oncologic safety of fat transfer in their study - suggest that lumpectomy accompanied by intraoperative radiation only, may have also impacted recurrence rates in Petit’s study. (22)…”

Section: Discussionmentioning

confidence: 86%

“…In addition, Gale and colleagues did not report an increased rate of recurrence following fat transfer in DCIS patients. (54) Fat transfer in these patients, however, was restricted to patients with clear margins and was delayed for 54 months after resection. By contrast, Petit waited a mean of 25 months and had positive or close margins in 42% of fat transferred patients but only 20% of controls, so the increased risk of recurrence may have been related to margin status.…”

Section: Discussionmentioning

confidence: 95%

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Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study

Myckatyn

Wagner

Mehrara

et al. 2017

Plastic &Amp; Reconstructive Surgery

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Background Fat transfer is an increasingly popular method for refining post-mastectomy breast reconstructions. However, concern persists that fat transfer may promote disease recurrence. Adipocytes are derived from adipose-derived stem cells and express adipocytokines that can facilitate active breast cancer cells in laboratory models. We sough to evaluate the association between fat transfer to the reconstructed breast and cancer recurrence in patients diagnosed with local or regional invasive breast cancers. Methods A multi-center, case-cohort study was performed. Eligible patients from four centers (Memorial Sloan Kettering, MD Anderson, Alvin J. Siteman, and the University of Chicago) were identified by each site’s institutional tumor registry or cancer data warehouse. Eligibility criteria were: mastectomy with immediate breast reconstruction between 2006 and 2011, age above 21, female sex, and incident diagnosis of invasive ductal carcinoma, stage I, II or III. Cases consisted of all recurrences during the study period, and controls consisted of a 30% random sample of the study population. Cox proportional hazards regression was used to evaluate for association between fat transfer and time to recurrence in bivariate and multivariate models. Results The time to disease recurrence unadjusted hazard ratio for fat transfer was 0.99 (95% CI: 0.56, 1.7). After adjustment for age, body mass index, stage, HER2/Neu receptor status, and estrogen receptor status, the hazard ratio was was 0.97 (95% CI: 0.54, 1.8). Conclusion In this population of breast cancer patients who had mastectomy with immediate reconstruction, fat transfer was not associated with a higher risk of cancer recurrence.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 95%

Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study

Myckatyn

Wagner

Mehrara

et al. 2017

Plastic &Amp; Reconstructive Surgery

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“…From our review of the literature, the median time from cancer surgery to fat grafting is highly variable and often not reported. In the cases where this information is available, the time may vary from a median 16.7 months to 36 months, and up to 48 months following primary cancer resection. Our patient received her first fat graft 3.5 months postmastectomy, well before the 2‐3 year median time of local breast cancer recurrence .…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

Unusual recurrence of breast cancer in a BRCA‐variant patient after fat grafting

Skendelas

Lee

Mangino

et al. 2018

Clinical Case Reports

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“…In order to reach such a conclusion of such wide-ranging, crucial importance, there is an obvious need for much more extensive data [92]. Thereafter, Gale et al [93] performed another casecontrol study in 2015, in which they aimed to replicate the research of Petit et al [91], using the same study design. They compared 211 patients who received fat grafting following treatment for breast cancer with a control group (422 patients).…”

Section: Clinical Studiesmentioning

confidence: 99%

The use of autologous fat grafts in breast surgery: A literature review

et al. 2019

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Autologous fat injection was first described roughly a century ago and has been used in surgery ever since. In addition to its use in many surgical fields, it is also frequently used for both aesthetic and reconstructive purposes in breast surgery. Since the application of fat grafting in breast surgery has steadily increased, studies investigating its reliability have simultaneously become increasingly common. Previous studies have reported that the use of fat grafting in breast surgery is reliable, but some pending questions remain about its routine use. In order to use fat grafts successfully in breast surgery, it is necessary to be familiar with the structure and content of adipose tissue, the efficacy of adipose stem cell-enriched fat grafts, the oncological safety of fat grafts, and the problems that may occur in the radiological follow-up of patients who undergo fat grafting procedures. In this literature review, we aim to discuss the use of fat grafts in breast surgery by investigating these common problems.

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A Case-Controlled Study of the Oncologic Safety of Fat Grafting

Abstract: IntroductionFat grafting to the breast fulfils an increased clinical demand for a biocompatible filler in contour refinement, volume adjustment and tissue rejuvenation both in cosmetic and reconstructive procedures, and has been used for total breast reconstruction 1-5 .

Cited by 109 publications

References 62 publications

Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study

Cancer Risk after Fat Transfer: A Multicenter Case-Cohort Study

Unusual recurrence of breast cancer in a BRCA‐variant patient after fat grafting

The use of autologous fat grafts in breast surgery: A literature review

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