A Case‐Control Study to Investigate Serological Correlates of Clinical Failure of 23‐Valent Pneumococcal Polysaccharide Vaccine in HIV‐1–Infected Ugandan Adults

French, Neil; Moore, Michael K.; Haikala, Raili; Käyhty, Helena; Gilks, Charles F.

doi:10.1086/421911

Cited by 33 publications

(15 citation statements)

References 15 publications

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“…Previous studies have suggested that a compromised memory B-cell response and/or low specific antibody titers may increase the risk of infections for the HIV-1 carrier 10,[13][14][15] and for children born to HIV-1-infected mothers. [16][17][18][19] To further dissect the relationship between loss of memory B cells, reduction of specific antibody levels, and disease progression, we studied subjects at different stage of disease (ie, PHI, CHI, and long-term nonprogressor [LTNP]) and also evaluated the effects of ART.…”

Section: Introductionmentioning

confidence: 99%

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

Titanji

Milito

Cagigi

et al. 2006

Blood

252

254

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Circulating memory B cells are severely reduced in the peripheral blood of HIV-1-infected patients. We investigated whether dysfunctional serologic memory to non-HIV antigens is related to disease progression by evaluating the frequency of memory B cells, plasma IgG, plasma levels of antibodies to measles, and Streptococcus pneumoniae, and enumerating measles-specific antibody-secreting cells in patients with primary, chronic, and long-term nonprogressive HIV-1 infection. We also evaluated the in vitro production of IgM and IgG antibodies against measles and S pneumoniae antigens following polyclonal activation of peripheral blood mononuclear cells (PBMCs) from patients. The percentage of memory B cells correlated with CD4 ؉ T-cell counts in patients, thus representing a marker of disease progression. While patients with primary and chronic infection had severe defects in serologic memory, long-term nonprogressors had memory B-cell frequency and levels of antigen-specific antibodies comparable with controls. We also evaluated the effect of antiretroviral therapy on these serologic memory defects and found that antiretroviral therapy did not restore serologic memory in primary or in chronic infection. We suggest that HIV infection impairs maintenance of long-term serologic immunity to HIV-1-unrelated antigens and this defect is initi- IntroductionThe ability to maintain an intact memory B-cell compartment is an essential component of the immune response to (re-) infections. 1 Maintenance of serologic memory is carried out by plasma cells and memory B cells [1][2][3] ; memory B cells play an essential role in the maintenance of antibody (Ab) levels by rapidly generating secondary immune responses upon reinfection or antigenic stimulation. 4 One of the most deleterious effects of HIV-1 infection is B-lymphocyte hyperactivation, which manifests as hypergammaglobulinemia, increased expression of activation markers, high spontaneous Ab production in vitro, and increased incidence of B-cell lymphomas. 5 Paradoxically, HIV-1-infected persons, especially those in advanced stages of disease, also have impaired humoral immune response to vaccination, and their B cells respond poorly to in vitro stimulation by common mitogens such as SAC and PWM. 5 Earlier studies suggest that naive and memory B cells differentially contribute to B-cell dysfunctions in HIV-1 infection. [6][7][8][9][10] Circulating memory B cells in peripheral blood from patients with chronic HIV-1 infection (CHI) are severely reduced and die by apoptosis. 6,11 Serum Abs against measles, tetanus toxoid, and HIV-1 antigens are significantly reduced in patients with low memory B cells, indicating that this phenotypic alteration may severely affect memory B-cell functions. 10 Recently, we reported that during primary HIV-1 infection (PHI), memory B cells are phenotypically and functionally altered though not significantly reduced in number. 12 These alterations were only partially recovered upon antiretroviral therapy (ART), suggesting that PHI sets the stage ...

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Section: Introductionmentioning

confidence: 99%

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

Titanji

Milito

Cagigi

et al. 2006

Blood

252

254

View full text Add to dashboard Cite

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“…The immunization increased the antibody levels in adults (18), pregnant women (19,20), healthy older people (21) and HIV-infected individuals (11,17,22). A 7-valent conjugate pneumococcal vaccine followed by a boost with the 23-valent polysaccharide vaccine resulted in a twofold increase in the levels of IgG specific for the serotype antigens 1, 6B, 9V, and 14 in 66% of HIV-infected adults (23), indicating that the response to vaccination against pneumococcal infection is an appropriate strategy to assess the level and quality of immune function.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zinc Supplementation on Serological Response to Vaccination AgainstStreptococcus Pneumoniaein Patients Undergoing Chemotherapy for Colorectal Cancer

Braga

Santos

Palmeira

et al. 2015

Nutrition and Cancer

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The aim of the study was to evaluate the effect of zinc supplementation on the antibody titer and the 23-valent pneumococcal seroconversion after vaccination in patients undergoing chemotherapy for colorectal cancer. The study included 25 patients undergoing postsurgery chemotherapy for colorectal adenocarcinoma (chemo group). Subjects were assessed in the perioperative period (prevaccination), before chemotherapy (4th wk) and after 3 cycles of chemotherapy (16th wk). Thirty-two healthy volunteers (control group) were included in the study. Participants received the 23-valent pneumococcal conjugate vaccine, and capsules containing zinc (Zn) sulfate (70 mg daily) or identical placebo capsules (containing wheat starch with no added Zn) for 16 wk and were randomly allocated on one of the following groups: chemo-Zn (n = 10), chemo-placebo (n = 15), control-Zn (n = 21), and control-placebo (n = 11). The antipneumococcal antibody titer against 6 polysaccharides was analyzed by ELISA and compared using linear mixed models. The seroconversion rate was compared using Fisher's exact test. An immune response to the vaccination against pneumococcus was observed in all participants. In the 16th wk, the polysaccharide 6 concentration was lower in the chemo-Zn group [2.96 (1.74-5.03) μg/mL] compared with the Chemo-Placebo group [10.75 (5.37-21.54) μg/mL] and the seroconversion rate was lower in the chemo-placebo (36%) compared with the control-placebo (85%) (P = 0.027). Zinc supplementation did not change the antibody titer after vaccination. However, the lower seroconversion rate observed in the chemo-placebo suggests an influence of zinc in the vaccinal protection.

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“…L'immunogénicité faible de ce vaccin est probablement la cause de son efficacité inconstante [34]. Les études immunologiques réalisées chez les patients infectés par le VIH ont toujours retrouvé une réponse anticorps significative mais sub-optimale, le taux d'anticorps mesuré étant plus bas que celui mesuré après une même vaccination chez le patient immunocompétent [35,36].…”

Section: Vaccin Polysaccaridiqueunclassified

Actualités dans les infections invasives à pneumocoque chez le patient infecté par le VIH

Munier

Lastours

Molina

2012

Journal des Anti-infectieux

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A Case‐Control Study to Investigate Serological Correlates of Clinical Failure of 23‐Valent Pneumococcal Polysaccharide Vaccine in HIV‐1–Infected Ugandan Adults

Cited by 33 publications

References 15 publications

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

Effect of Zinc Supplementation on Serological Response to Vaccination AgainstStreptococcus Pneumoniaein Patients Undergoing Chemotherapy for Colorectal Cancer

Actualités dans les infections invasives à pneumocoque chez le patient infecté par le VIH

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