A Case-Control Study to Estimate the Effectiveness of Maternal Pertussis Vaccination in Protecting Newborn Infants in England and Wales, 2012-2013

Dabrera, Gavin; Amirthalingam, Gayatri; Andrews, Nick; Campbell, Helen; Ribeiro, Sonia; Kara, Edna; Fry, Norman K.; Ramsay, Mary

doi:10.1093/cid/ciu821

Cited by 332 publications

(215 citation statements)

References 13 publications

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“…This limitation is illustrated by the failure of various preparations of 1 pertussis immune globulin to prevent colonization (and subsequent invasive infection) in 2 humans and animal models (127)(128)(129). The recently observed effectiveness of maternal 3 pertussis immunization in preventing infant disease represents an important advancement 4 (130). If the benefit is largely attributable to minimization of disease severity such encounters 5 could result in passive-active immunity, with active immunity following attenuated natural 6 infection (131).…”

Section: Prevention Of Infection and Disease 18mentioning

confidence: 99%

Maternal immunisation: collaborating with mother nature

Marchant

Sadarangani

Garand

et al. 2017

The Lancet Infectious Diseases

146

124

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Maternal immunization offers much hope to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza and pertussis immunization during pregnancy has led to consideration of additional maternal immunization strategies to prevent Group B Streptococcus (GBS) and respiratory syncytial virus (RSV) infections, among others. However, there remain multiple gaps in our knowledge regarding the immunobiology of maternal immunization that prevent optimal design and application of this successful public health intervention. An innovative landscape analysis was therefore undertaken to identify research priorities. Key topics were delineated through review of the published literature, consultation with vaccine developers and regulatory agencies, and a collaborative workshop gathering experts across several current maternal immunization initiatives -GBS, RSV, pertussis, and influenza. Finally, a global online survey prioritized the identified knowledge gaps based on expert opinion regarding their importance and relevance. This article presents the results of this worldwide landscape analysis and discusses the identified research gaps.

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Section: Prevention Of Infection and Disease 18mentioning

confidence: 99%

Maternal immunisation: collaborating with mother nature

Marchant

Sadarangani

Garand

et al. 2017

The Lancet Infectious Diseases

146

124

View full text Add to dashboard Cite

show abstract

“…22,23 A recent study found that siblings (median age 8 years) are now the most common source of pertussis infection in infants 24 ; however, it is not clear whether adolescent Tdap boosters are important for protecting infants. 25 Tdap vaccination of pregnant women is likely to have a larger impact on pertussis in infants.…”

Section: Figurementioning

confidence: 99%

Waning Tdap Effectiveness in Adolescents

et al. 2016

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BACKGROUND AND OBJECTIVE: Because the effectiveness of diphtheria-tetanus-acellular pertussis (DTaP) vaccine wanes substantially after the fifth dose at ages 4 to 6 years, there is a growing cohort of adolescents who rely on tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) for protection against pertussis. Yet despite high Tdap vaccine coverage among adolescents, California experienced large pertussis outbreaks in 2010 and 2014. We investigated Tdap vaccine effectiveness (VE) and waning within Kaiser Permanente Northern California among adolescents exclusively vaccinated with DTaP vaccines.

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“…In the UK alone, 14 infants died as a result of confirmed pertussis in 2012 [28]. The UK antenatal pertussis immunization programme has been very successful, with coverage of over 60% and vaccine effectiveness of 91% against pertussis in infants less than 3 months [28,29]. However, high concentrations of maternally derived antibody will alter the baseline for responses to vaccines as part of the EPI schedule and therefore have the potential to blunt the infant's rstb.royalsocietypublishing.org Phil.…”

Section: Immunization Of Pregnant Women and Influence On Infant Immunmentioning

confidence: 99%

Factors influencing innate immunity and vaccine responses in infancy

Kampmann

Jones

2015

Phil. Trans. R. Soc. B

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Despite significant progress in reducing the burden of mortality in children under the age of five, reducing mortality in newborns remains a major challenge. Infection plays a significant role in infant deaths and interventions such as early vaccination or antenatal immunization could make a significant contribution to prevention of such deaths. In the last few years, we have gained new insights into immune ontogeny and are now beginning to understand the impact of vaccines, nutrition and environmental factors on ‘training′ of the immune response in early life. This review article sets out to explain why vaccine responses can be heterogeneous between populations and individuals by providing examples chosen to illustrate the impact of host, pathogen and environmental factors on shaping the immune ‘interactome′ in young children.

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A Case-Control Study to Estimate the Effectiveness of Maternal Pertussis Vaccination in Protecting Newborn Infants in England and Wales, 2012-2013

Abstract: Maternal pertussis vaccination is effective in preventing pertussis infection in infants aged <8 weeks and may be considered in other countries experiencing high levels of pertussis notifications.

Cited by 332 publications

References 13 publications

Maternal immunisation: collaborating with mother nature

Maternal immunisation: collaborating with mother nature

Waning Tdap Effectiveness in Adolescents

Factors influencing innate immunity and vaccine responses in infancy

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