A case-control study to determination FBXW7 and Fetuin-A levels in patients with type 2 diabetes in Iraq

Mohammed, Suhayla K.; Taha, Ekhlass M.; Muhi, Samer Abdulhasan

doi:10.1007/s40200-021-00738-x

Cited by 6 publications

(7 citation statements)

References 28 publications

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“…Moreover, high ceramide levels in the hippocampus are associated with decreased neurogenesis, neuronal maturation, and neuronal survival [131] and increased amygdala sphingolipids are associated with anxiety-like behaviors in animal models [132]. This is a first report that lowered FBXW7 may be associated with depressive and anxiety symptoms, although these effects may be mediated via increased IR because lowered FBXW7 is associated with hyperglycemia, IR, and the development of T2DM [32]. Moreover, as explained in the Introduction, FBXW7 modulates some pathways that play a role in mood disorders, including neurogenesis, mTOR, DISC, and PGC-1α [36,38,39].…”

Section: Biomarkers Of Affective Symptoms Due To T2dmmentioning

confidence: 86%

“…FBXW7 (F-box/WD repeat-containing protein 7), also known as human CDC4, is an E3 ubiquitin ligase which targets cyclin E for ubiquitin-mediated degradation [31]. Lowered FBXW7 in animal models and humans is associated with hyperglycemia, IR, and the development of T2DM [32]. In primary neurons, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and mechanistic target of rapamycin complex 1 (mTORC1) are FBXW7 substrates and regulate glucose homeostasis [33,34].…”

Section: Introductionmentioning

confidence: 99%

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Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

Al‐Hakeim

Hadi

Jawad

et al. 2022

JPM

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Type 2 diabetes mellitus (T2DM) is frequently accompanied by affective disorders with a prevalence of comorbid depression of around 25%. Nevertheless, the biomarkers of affective symptoms including depression and anxiety due to T2DM are not well established. The present study delineated the effects of serum levels of copper, zinc, β-arrestin-1, FBXW7, lactosylceramide (LacCer), serotonin, calcium, magnesium on severity of depression and anxiety in 58 men with T2DM and 30 healthy male controls beyond the effects of insulin resistance (IR) and atherogenicity. Severity of affective symptoms was assessed using the Hamilton Depression and Anxiety rating scales. We found that 61.7% of the variance in affective symptoms was explained by the multivariate regression on copper, β-arrestin-1, calcium, and IR coupled with atherogenicity. Copper and LacCer (positive) and calcium and BXW7 (inverse) had significant specific indirect effects on affective symptoms, which were mediated by IR and atherogenicity. Copper, β-arrestin-1, and calcium were associated with affective symptoms above and beyond the effects of IR and atherogenicity. T2DM and affective symptoms share common pathways, namely increased atherogenicity, IR, copper, and β-arrestin-1, and lowered calcium, whereas copper, β-arrestin-1, calcium, LacCer, and FBXW7 may modulate depression and anxiety symptoms by affecting T2DM.

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Section: Biomarkers Of Affective Symptoms Due To T2dmmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

Al‐Hakeim

Hadi

Jawad

et al. 2022

JPM

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“…Serum glucose determination using the kit supplied by Bio System, Spain. The measurement of insulin was carried out using an ELISA kit, which was provided by Demeditec, a German 17 …”

Section: Biochemical Analysismentioning

confidence: 99%

“…The measurement of insulin was carried out using an ELISA kit, which was provided by Demeditec, a German. 17 The homeostasis-based model for assessing IR (HOMA-IR) is used to estimate IR. IR = fasting insulin (mlU/L) X fasting glucose (mmol/L)/22.5.…”

Section: Biochemical Analysismentioning

confidence: 99%

Effect of interleukin‐12 gene expression on insulin resistance in patients with acne vulgaris

AbdElneam,

Al‐Dhubaibi,

Bahaj

et al. 2023

Skin Research and Technology

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BackgroundInsulin resistance (IR) is a condition where cells become resistant to insulin, causing impaired glucose uptake and increased blood glucose levels. Interleukin‐12 (IL‐12), a cytokine, regulates the immune system. High levels of IL‐12 can lead to chronic inflammation, exacerbate resistance to insulin, and contribute to type 2 diabetes. Also, link IR to acne vulgaris (AV), as it reduces tissue sensitivity to insulin, causing increased insulin levels and sebum production, which can contribute to acne development.AimTo explore the role of IL‐12 gene expression on IR in AV patients and to study the role of IL‐12 gene in the development of AV.Subjects and MethodsA case–control study was performed on 68 AV patients and 68 healthy controls. The biochemical analysis included fasting glucose, fasting insulin, (HOMA‐IR), and serum IL‐12 level. IL‐12 gene expression was performed by quantitative real‐time PCR for both two groups. In addition, folding change was calculated by using the standard 2–(∆∆Ct) method.ResultIL‐12 level, IL‐12 folding change, fasting insulin, and IR were all increased in acne patients. A highly significant linear correlation was found between IL‐12 folding change and both IL‐12 levels and IR. There is a substantial positive significant simple linear association between IL‐12 level and IL‐12 folding change, as well as IR and IL‐12 folding change, in moderate and severe acne.ConclusionIL‐12 gene has an important role in IR and the development of acne in AV patients.

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“…For saturated fatty acids, FtA is an adapter protein (endogenous ligand) by which they activate Toll-like receptor 4 [105, 108]. FtA plays an important role in the binding of minerals, lectins (including galectin-3) [108, [135][136][137] or lipids, is involved in inhibiting the signal transmission to beta-growth factor or anthonization of insulin receptors [98,108,138]. FtA is a necessary cofactor in inhibiting the expression of proinflammatory cytokine, tumor necrosis factor, together with spermidine, activating the accumulation of triacylglycerol and NF-κB [98, 108] (see figure 3).…”

Section: What Do We Know About These Markers?mentioning

confidence: 99%

The value of proteomic studies of the latest markers of kidney damage in the urine to assess the course, progression and complications in patients with CKD

Denova

2022

KIDNEYS

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Сhronic kidney Disease (CKD) is the cause of both morbidity and mortality worldwide. In Ukraine, 12 % of the population is diagnosed with CKD. Significantly worsen the quality of life in patients with CKD progression of renal fibrosis and impaired mineral homeostasis. Early diagnosis and treatment are the main measures to prevent CKD progression and delay adverse effects. Deficiency of early, non-invasive biomarkers adversely affects the ability to rapidly detect and treat CKD. Proximal tubular lesions play an important role in the progression of CKD. There are new markers of kidney damage, such as uromodulin (UMOD), Klotho protein and post-translational modifications of fetuin A (FtA). Treatment of CKD in the early stages may improve renal function and/or slow the progression of CKD.

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A case-control study to determination FBXW7 and Fetuin-A levels in patients with type 2 diabetes in Iraq

Cited by 6 publications

References 28 publications

Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

Effect of interleukin‐12 gene expression on insulin resistance in patients with acne vulgaris

The value of proteomic studies of the latest markers of kidney damage in the urine to assess the course, progression and complications in patients with CKD

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