A Case–Control Study on the Origin of Atypical Scrapie in Sheep, France

Fediaevsky, Alexandre; Morignat, Eric; Ducrot, Christian; Calavas, Didier

doi:10.3201/eid1505.081119

Cited by 36 publications

(42 citation statements)

References 33 publications

(48 reference statements)

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“…Recent studies revealed that polymorphisms of codons 141 and 154 are correlated with atypical scrapie development (12,22); moreover, in a matched case-control study, atypical scrapie related genotypes were classified into five risk groups (group 1 to group 5) according to their odds ratio (13). Classification of the Karacabey …”

Section: Discussionmentioning

confidence: 99%

Evaluation of the genetic resistance status to classical and atypicalscrapie in Karacabey merino rams

Yaman¹,

Soysal²,

Ün³

2015

Turk J Vet Anim Sci

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Section: Discussionmentioning

confidence: 99%

Evaluation of the genetic resistance status to classical and atypicalscrapie in Karacabey merino rams

Yaman¹,

Soysal²,

Ün³

2015

Turk J Vet Anim Sci

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“…Therefore, counties with a large percentage of small flocks (<20 ewes) might have been overrepresented. To assess the influence of geographic selection bias, we conducted a sensitivity analysis by using 2 methods: (1) weighting of controls in the final model with weights being defined for each county as the ratio of the percentage of flocks >20 ewes in the county divided by the percentage of flocks >20 ewes at the national scale, and (2) introduction of sheep production areas as random coefficients in the final model.78 …”

Section: (E) Describe Any Analyses Used To Assess the Robustness Ofmentioning

confidence: 99%

Explanation and Elaboration Document for the STROBE‐Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary Extension

O’Connor

Sargeant

Dohoo

et al. 2016

Veterinary Internal Medicne

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The STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement was first published in 2007 and again in 2014. The purpose of the original STROBE was to provide guidance for authors, reviewers, and editors to improve the comprehensiveness of reporting; however, STROBE has a unique focus on observational studies. Although much of the guidance provided by the original STROBE document is directly applicable, it was deemed useful to map those statements to veterinary concepts, provide veterinary examples, and highlight unique aspects of reporting in veterinary observational studies. Here, we present the examples and explanations for the checklist items included in the STROBE‐Vet statement. Thus, this is a companion document to the STROBE‐Vet statement methods and process document (JVIM_14575 “Methods and Processes of Developing the Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary (STROBE‐Vet) Statement” undergoing proofing), which describes the checklist and how it was developed.

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“…The analysis of the data collected through the active surveillance program (Fediaevsky et al, 2010;Fediaevsky et al, 2009) seems to indicate that the capacity of Atypical scrapie cases to transmit disease to other sheep under field conditions is low and possibly nil. In most of the Atypical scrapie flocks, only a single case is found.…”

Section: Atypical Scrapiementioning

confidence: 99%

“…At slaughterhouse the main biases include over or under representation of some geographical regions, non random timing of sampling such as systematic same week days for sampling, sampling rate related to flock size or commercial pattern, biases on animal age or general appearance (Del Rio Fediaevsky et al, 2009;Tongue et al, 2008).…”

Section: Tse Epidemiological Situation In the Small Ruminant Europeanmentioning

confidence: 99%

Scientific Opinion on BSE/TSE infectivity in small ruminant tissues

Andréoletti¹,

Budka²,

Bunčić³

et al. 2010

EFS2

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The objectives addressed were i) to provide an update on TSE (Transmissible Spongiform Encephalopathy) infectivity distribution in small ruminant tissues; and ii) to indicate based on the current epidemiological situation as regards to BSE (Bovine Spongiform Encephalopathy) in the small ruminant population in the EU (European Union), whether a review of the existing SRM (Specified Risk Materials) list for small ruminants should be envisaged with regard to the potential exposure to the BSE agent. The appraisal was addressed by reviewing for Classical scrapie, BSE and Atypical scrapie in small ruminants aspects related to: i) tissue infectivity distribution according to the age and the genotype of sheep and goats; and ii) the infectious load in the different tissues. In order to perform the assessment all the currently available scientific results were reviewed, and data on TSE monitoring in small ruminants in the EU and on small ruminants slaughtered by species and age category in each EU Member State were considered. The reduction of the infectivity associated to the carcass of an infected individual achieved by the current SRM policy in small ruminants for Classical scrapie and BSE was estimated. The total number of Classical scrapie infected sheep and goats that could enter yearly into the food chain was provided. Moreover, considerations about Atypical scrapie were given. A set of simulations allowing estimating the impact of different policy options on the BSE infectious load potentially present in an infected sheep was provided. Therefore, the EC asked EFSA: i) to update, as regards small ruminants and on the basis of the most recent scientific data, the SSC scientific opinion from 2002 on TSE infectivity distribution in ruminant tissues; ii) to indicate based on the current epidemiological situation as regards BSE in the small ruminant population in EU, whether a review of the existing SRM list for small ruminants should be envisaged with regard to the potential exposure to the BSE agent. © EuropeanThe BIOHAZ Panel addressed the mandate by reviewing individually for Classical scrapie, BSE and Atypical scrapie in small ruminants aspects related to: i) tissue infectivity distribution according to the age and the genotype of sheep and goats; and ii) the infectious load in the different tissues.In order to perform the assessment all the currently available scientific results were reviewed. Data about the TSE monitoring in small ruminants in the EU were provided by the European Commission and information on small ruminants slaughtered by species and age category in each EU Member State were provided by the EFSA Focal Points Network.It was emphasized that this assessment required several assumptions. Moreover, the estimates of the infectious load are based on a simple approach using computations based on a low and a high estimate of each of the parameters. This provides order of magnitude estimates of the infectious load of TSE agents entering into the food chain at EU 27 level. This approach could be r...

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A Case–Control Study on the Origin of Atypical Scrapie in Sheep, France

Cited by 36 publications

References 33 publications

Evaluation of the genetic resistance status to classical and atypicalscrapie in Karacabey merino rams

Evaluation of the genetic resistance status to classical and atypicalscrapie in Karacabey merino rams

Explanation and Elaboration Document for the STROBE‐Vet Statement: Strengthening the Reporting of Observational Studies in Epidemiology—Veterinary Extension

Scientific Opinion on BSE/TSE infectivity in small ruminant tissues

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