A case-control study on the risk factors for hemorrhagic fever with renal syndrome

Wang, Xiaochen; Shen, Wenqi; Qin, Yuanfang; Li, Ying; Li, Haipeng; Lu, Jiankui; Lu, Jing; Zhang, Nan; Li, Zhifeng; Zhou, Wei-Zhong; Tang, Fenyang; Zhu, Fanxiu; Hu, Jianli; Bao, Changjun

doi:10.1186/s12879-020-4830-5

Cited by 12 publications

(10 citation statements)

References 12 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our research showed that of the patients assessed, middle-aged patients were predominantly affected. Furthermore, most patients were men, and the main occupation was farming, consistent with the findings of previous reports 1 , 13 , 14 , 25 . The risk prediction model showed that cultivated land was the highest risk factor for HFRS 16 .…”

Section: Discussionsupporting

confidence: 91%

Epidemiology of hemorrhagic fever with renal syndrome in Tai’an area

Bi¹,

Zhang³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Hemorrhagic fever with renal syndrome (HFRS), a serious threat to human health, is mainly transmitted by rodents in Eurasia. The risk of disease differs according to sex, age, and occupation. Further, temperature and rainfall have some lagging effects on the occurrence of the disease. The quantitative data for these factors in the Tai’an region of China are still unknown. We used a forest map to calculate the risk of HFRS in different populations and used four different mathematical models to explain the relationship between time factors, meteorological factors, and the disease. The results showed that compared with the whole population, the relative risk in rural medical staff and farmers was 5.05 and 2.00, respectively (p < 0.05). Joinpoint models showed that the number of cases decreased by 33.32% per year from 2005 to 2008 (p < 0.05). The generalized additive model showed that air temperature was positively correlated with disease risk from January to June, and that relative humidity was negatively correlated with risk from July to December. From January to June, with an increase in temperature, after 15 lags, the cumulative risk of disease increased at low temperatures. From July to December, the cumulative risk decreased with an increase in the relative humidity. Rural medical staff, farmers, men, and middle-aged individuals were at a high risk of HFRS. Moreover, air temperature and relative humidity are important factors that affect disease occurrence. These associations show lagged and differing effects according to the season.

show abstract

Section: Discussionsupporting

confidence: 91%

Epidemiology of hemorrhagic fever with renal syndrome in Tai’an area

Bi¹,

Zhang³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…As hantaviruses may remain infective up to 15 days in a temperate environment, and up to 24 h for environmental temperature up to 37 • C [79,80], a direct and known interaction with the competent hosts is not required and may occur unnoticed. Therefore, living in a rural environment and/or in precarious, non-hygienic settings, and any interaction with environments potentially shared by the competent hosts represent the most significant risk factors for hantavirus infection [6,50,81,82]. In other words, any variation and/or combination of the aforementioned factors directly influences the actual risk profile of the targeted population.…”

Section: Discussionmentioning

confidence: 99%

Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis

Riccò

Peruzzi

Ranzieri

et al. 2021

Viruses

View full text Add to dashboard Cite

Hantaviruses are zoonotic pathogens that can cause serious human disorders, including hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. As the main risk factor for human infections is the interaction with rodents, occupational groups such as farmers and forestry workers are reportedly at high risk, but no summary evidence has been collected to date. Therefore, we searched two different databases (PubMed and EMBASE), focusing on studies reporting the prevalence of hantaviruses in farmers and forestry workers. Data were extracted using a standardized assessment form, and results of such analyses were systematically reported, summarized and compared. We identified a total of 42 articles, including a total of 28 estimates on farmers, and 22 on forestry workers, with a total workforce of 15,043 cases (821 positive cases, 5.5%). A pooled seroprevalence of 3.7% (95% confidence interval [95% CI] 2.2–6.2) was identified in farmers, compared to 3.8% (95% CI 2.6–5.7) in forestry workers. Compared to the reference population, an increased occurrence was reported for both occupational groups (odds ratio [OR] 1.875, 95% CI 1.438–2.445 and OR 2.892, 95% CI 2.079–4.023 for farmers and forestry workers, respectively). In summary, our analyses stress the actual occurrence of hantaviruses in selected occupational groups. Improved understanding of appropriate preventive measures, as well as further studies on hantavirus infection rates in reservoir host species (rodents, shrews, and bats) and virus transmission to humans, is needed to prevent future outbreaks.

show abstract

“…Hantaviruses also pose a risk to food consumption as well if improperly stored (Risteska-Nejashmikj et al, 2019;Wang et al, 2020). Hantaviruses, with PUUV and ANDV being studied, are not easily digested by stomach acids and can survive long enough to be passed into the gastrointestinal tract.…”

Section: Unconventional Warfare Settings and Civilian Targetsmentioning

confidence: 99%

Biodefense Implications of New-World Hantaviruses

D’Souza

Patel

2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Hantaviruses, part of the Bunyaviridae family, are a genus of negative-sense, single-stranded RNA viruses that cause two major diseases: New-World Hantavirus Cardiopulmonary Syndrome and Old-World Hemorrhagic Fever with Renal Syndrome. Hantaviruses generally are found worldwide with each disease corresponding to their respective hemispheres. New-World Hantaviruses spread by specific rodent-host reservoirs and are categorized as emerging viruses that pose a threat to global health and security due to their high mortality rate and ease of transmission. Incidentally, reports of Hantavirus categorization as a bioweapon are often contradicted as both US National Institute of Allergy and Infectious Diseases and the Centers for Disease Control and Prevention refer to them as Category A and C bioagents respectively, each retaining qualitative levels of importance and severity. Concerns of Hantavirus being engineered into a novel bioagent has been thwarted by Hantaviruses being difficult to culture, isolate, and purify limiting its ability to be weaponized. However, the natural properties of Hantaviruses pose a threat that can be exploited by conventional and unconventional forces. This review seeks to clarify the categorization of Hantaviruses as a bioweapon, whilst defining the practicality of employing New-World Hantaviruses and their effect on armies, infrastructure, and civilian targets.

show abstract

A case-control study on the risk factors for hemorrhagic fever with renal syndrome

Cited by 12 publications

References 12 publications

Epidemiology of hemorrhagic fever with renal syndrome in Tai’an area

Epidemiology of hemorrhagic fever with renal syndrome in Tai’an area

Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis

Biodefense Implications of New-World Hantaviruses

Contact Info

Product

Resources

About