A case-control study on occupational risk factors for sino-nasal cancer

d’Errico, Angelo; Pasian, Sherri; Baratti, Alberto; Zanelli, R.; Alfonzo, Santo; Gilardi, Luisella; Beatrice, Fabio; Bena, Antonella; Costa, Giuseppe

doi:10.1136/oem.2008.041277

Cited by 84 publications

(91 citation statements)

References 36 publications

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“…Intestinal type adenocarcinoma (28% -41.8%) was the second most frequent histopathology after adenocarninoma with no other specification. Twentythree patients (34.3%) had tumor extension to orbit (9), skull base (2), orbit and skull base (8) and others places like pterigopalatine fossa and cheek (5). According to T stages, 1 (1.5%) patient was T1, 19 (28.4%) T2, 21 (31.3%) T3, 21 (31.3%) T4a and 5 (7.5%) T4b.…”

Section: Resultsmentioning

confidence: 99%

“…The average age for presentation is 50 -60 years, with male predominance (2 -4:1) [4,7]. Epidemiologically, adenocarcinoma has been associated with workers exposed to hardwood dust since this relation was first reported in 1965 by MacBeth [1,8]. These are mostly intestinal-type sinonasal adenocarcinomas and show a strong preference for the ethmoid sinus [4].…”

Section: Introductionmentioning

confidence: 99%

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Sinonasal Adenocarcinoma—Experience of an Oncology Center

Bernardo¹,

Ferreira²,

Silva³

et al. 2013

IJOHNS

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Introduction and Objectives: Sinonasal tumours represent only 3% of all head and neck cancers. Adenocarcinoma is the second most frequent histopathology type. Hardwood exposure has been considered a risk factor. Sinonasal adenocarcinoma grows silently which leads to a late diagnosis and low survival rates. The aim of this study was to present our experience in the management of the patients with sinonasal adenocarcinoma. Method: Retrospective medical records review of patients with sinonasal adenocarcinomas (1974 to 2009). Results: From 301 patients with sinonasal tumors, 67 had histology of adenocarcinoma. Patient average age was 60.1 ± 11.1 years (30 -84 years). 83.6% were man. 65.7% had history of working with wood. 70.1% of the patients had advance disease. The most common treatment strategy was external surgery (lateral rhinotomy (47.8%), sublabial (17.9%) or cranio-facial resection (6%)) or endoscopic approaches with postoperative radiotherapy. The 3 and 5 years overall survival rate were 60% and 49%, respectively. Conclusions: Our group study showed similar epidemiologic characteristics than other series. We confirmed sinonasal adenocarcinomas tendency to late diagnosis and wood dust exposure relation. In our experience, the limited surgical treatment (without craniofacial resection) and postoperative radiotherapy has good survival rates results, similar to other departments who consider the craniofacial resection as the standard treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sinonasal Adenocarcinoma—Experience of an Oncology Center

Bernardo¹,

Ferreira²,

Silva³

et al. 2013

IJOHNS

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“…Epithelial tumours represent over two/third of the SNC and, among them, the most common histotypes are adenocarcinoma and squamous cell carcinoma (SCC) (2) with European studies showing a frequency of adenocarcinoma (3)(4)(5) higher than that reported in the corresponding Northern American studies (6,7) . Other less common sinonasal epithelial histologies are adenoid cystic cancer (ACC) and undifferentiated carcinoma (SNUC).…”

Section: Introductionmentioning

confidence: 97%

“…Occupational risk factors that have been related with a higher incidence of SNC include wood dust (13) , leather dust (14) , nickel compounds and hexavalent chromium (15) , formaldehyde and other solvents (2,16) and polycyclic aromatic hydrocarbons (PAHs) (17) .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of occupational hazards in patients with different types of epithelial sinonasal cancers

Bonzini¹,

Batttaglia²,

Parassoni³

et al. 2013

Rhin

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SummaryBackground: Occupational exposure to carcinogens contributes greatly to the etiology of sinonasal cancer (SNC), but the role of different risk factors in determining different histological subtypes is disputed.Methodology: All consecutive surgical epithelial SNC cases (case-series study) underwent a systematic occupational medicine examination to determine previous exposure to a wide range of work-related chemical hazards. Results:We investigated 65 SNC cases including intestinal-type adenocarcinoma [ITAC] squamous-cell carcinoma [SCC], and others. Occupational exposure was recognized for 39 cases. Occupational exposures were sensibly more frequent among ITAC than among SCC or other histotypes. Occupational exposure in ITAC cases was to leather or wood dust only, while among non-ITAC cases, we recognised exposure to formaldehyde, solvents and metal fumes. A high proportion of SNC with occupational exposure originated in the ethmoidal epithelium. Conclusion:In our case-series of SNC, a very high frequency of previous occupational exposure to carcinogens was detected, suggesting that occupational hazards may be associated to the aetiopathogenesis, primarily for ITAC, but also for other histotypes. Besides leather or wood, other chemical agents must be recognized as occupational risk factors.

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“…While occupational exposures to some chemical and physical agents are known to be risk factors for several cancer types [7][8][9][10][11], little is known regarding the role of occupational factors in the development of meningioma [3]. Some studies have shown associations between specific works (e.g.…”

Section: Introductionmentioning

confidence: 99%

Occupational exposure to metals and risk of meningioma: a multinational case-control study

et al. 2016

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The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study.INTEROCC is a seven-country population-based case-control study including 1,906 adult meningioma cases and 5,565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression.Although more controls than cases were ever exposed to metals (14% vs. 11%, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR=1.26, 95%CI 1.0-1.58). In women, an increased OR of 1.70 (95%CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19 (95% CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures.In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.6

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A case-control study on occupational risk factors for sino-nasal cancer

Cited by 84 publications

References 36 publications

Sinonasal Adenocarcinoma—Experience of an Oncology Center

Sinonasal Adenocarcinoma—Experience of an Oncology Center

Prevalence of occupational hazards in patients with different types of epithelial sinonasal cancers

Occupational exposure to metals and risk of meningioma: a multinational case-control study

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