A case–control study of the risk of adverse perinatal outcomes due to tuberculosis during pregnancy

Asuquo, Bassey; Vellore, Arun Dev; Walters, Gareth; Manney, Sarah; Mignini, Luciano; Kunst, Heinke

doi:10.3109/01443615.2012.704436

Cited by 24 publications

(29 citation statements)

References 16 publications

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“…Pregnant women with pulmonary tuberculosis have higher odds of PTB (Asuquo et al, 2012). In a stillbirth where the mother had an upper respiratory infection of F. nucleatum , the bacterium was isolated from the placenta and the infant, and the same clone was identified in her subgingival plaque, but not in the vagina or rectum (Han et al, 2010).…”

Section: Results and Conclusionmentioning

confidence: 99%

Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women

Mendz

Kaakoush

Quinlivan

2013

Front. Cell. Infect. Microbiol.

135

112

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Infection-related preterm birth is a leading cause of infant mortality and morbidity; knowledge of bacterial populations invading the amniotic cavity and the routes of invasion is required to make progress in the prevention of preterm birth. Significant advances have been made in understanding bacterial communities in the vagina, but much less studied are intra-uterine bacterial populations during pregnancy. A systematic review of data published on the intra-uterine microbiome was performed; molecular information and summaries of species found in healthy individuals and in women with diagnosed infections served to construct a database and to analyse results to date. Thirteen studies fulfilled the review's inclusion criteria. The data of various investigations were collated, organized, and re-analyzed to achieve a more comprehensive understanding of microbial populations in the intra-amniotic space. The most common intra-amniotic bacterial taxa were species that can colonies the vagina in health and disease; there were others associated with the habitats of the mouth, gastrointestinal tract, and respiratory tract. The results suggest a central role for the ascending route of infections during pregnancy, and point to a possible secondary contribution via haematogenous invasion of the intra-amniotic space. The complete census of the intra-uterine microbiome awaits completion.

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Section: Results and Conclusionmentioning

confidence: 99%

Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women

Mendz

Kaakoush

Quinlivan

2013

Front. Cell. Infect. Microbiol.

135

112

View full text Add to dashboard Cite

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“…Therefore a high index of suspicion and early referral and diagnosis is recommended. 43 It is crucial to rule out TB infection in new-borns whose mothers have been diagnosed with TB, and this investigation should be performed at the time of delivery. Diagnosis of neonatal TB may be perplexing, and the diagnostic delay may have irreversible consequences for the infant.…”

Section: Risk For Congenital Tbmentioning

confidence: 99%

Need for increased clinical awareness of tuberculosis during pregnancy and puerperium in India

Jain¹,

Chaudhari²

2016

Int J Reprod Contracept Obstet Gynecol

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“…4 A new case-control study conducted in UK showed a lower birth weight in infants born to mothers with TB, especially if pulmonary disease, despite receiving standard treatment. 5 Maternal TB is a risk factor for child TB. Congenital TB is rare, 6 but the risk of transmission to the infant in the postpartum period is higher due to inhalation of aerial droplets coughed out by the mother.…”

Section: Maternal Tuberculosis and Pregnancy Outcomesmentioning

confidence: 99%

Tuberculosis and Pregnancy: An Updated Systematic Review

Repossi¹,

Bothamley²

2015

Pulm Res Respir Med Open J

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Tuberculosis (TB) affects women, especially in the child-bearing years. TB is associated with a poorer outcome of pregnancy, although this may be due to the general risk factors for TB, namely poverty, malnutrition and overcrowding. New studies have shown that symptom screening has a low sensitivity and specificity, but is improved by the addition of a tuberculin skin test (TST) or interferon-gamma release assay (IGRA) or, in high incidence areas, DNA amplification tests (e.g. Xpert MTB/RIF). TB-HIV co-infection is a common cause of mortality and morbidity in pregnancy. The diagnostic process remains the same in pregnancy, but non-specific symptoms and extra pulmonary disease demand a higher level of suspicion of TB. Standard first-line treatment is safe in pregnancy. Data on second-line drugs in pregnancy is still limited, but injectable drugs may affect the hearing and balance of the fetus. The IGRA responses appear to change during pregnancy, with more positive responses after delivery. The increasing incidence of drug-resistant TB, especially in Eastern Europe and Central Asia, requires an evaluation of the safety of second-line drugs in pregnancy.

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A case–control study of the risk of adverse perinatal outcomes due to tuberculosis during pregnancy

Cited by 24 publications

References 16 publications

Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women

Bacterial aetiological agents of intra-amniotic infections and preterm birth in pregnant women

Need for increased clinical awareness of tuberculosis during pregnancy and puerperium in India

Tuberculosis and Pregnancy: An Updated Systematic Review

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