A case-control study of risk factors for male infertility in Nigeria

Okonofua, Friday; Menakaya, U.; Onemu, S. O.; Omo‐Aghoja, Lawrence; Bergström, Staffan

doi:10.1111/j.1745-7262.2005.00046.x

Cited by 43 publications

(43 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1,3,6,12,20] Environmental factors such as exposure to heat and chemicals, lifestyle factors such as smoking and alcohol consumption, chronic medical conditions such as diabetes mellitus and thyroid disease, previous groin surgery, including herniorrhaphy or varicocelectomy, and past mumps infection have been demonstrated as having adverse effects on sperm parameters. [12,23] Consistent with previous reports, [24][25][26] this study demonstrated a significant association between smoking habit, past infection with mumps (mumps orchitis) and past groin surgery and abnormal sperm parameters, although Okonofua et al [26] also reported a significant association with alcohol consumption, among other factors.…”

Section: Discussionsupporting

confidence: 81%

Factors predictive of abnormal semen parameters in male partners of couples attending the infertility clinic of a tertiary hospital in south-western Nigeria

Aduloju

Adegun

2016

S Afr J OG

View full text Add to dashboard Cite

Background. Infertility is a common gynaecological problem and male factors contribute significantly to its aetiology. Semen analysis has remained useful for investigation of male factor infertility. Objective. To assess the pattern of semen parameters, and predictive factors associated with abnormal parameters, in male partners of infertile couples attending a Nigerian tertiary hospital. Methods. A descriptive study of infertile couples presenting at the clinic between January 2012 and December 2015 at Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria was done. Seminal fluid from the male partners was analysed in the laboratory using the World Health Organization 2010 criteria for human semen characteristics. Data were analysed using SPSS 17 and logistic regression analysis was used to determine the predictive factors associated with abnormal semen parameters. Results. A total of 443 men participated in the study and 38.2% had abnormal sperm parameters. Oligozoospermia (34.8%) and asthenozoospermia (26.9%) were the leading single-factor abnormalities found, and astheno-oligozoospermia occurred in 14.2% and oligoasthenoteratozoospermia in 3.6% of cases. The prevalence of azoospermia was 3.4%. Smoking habit, past infection with mumps and previous groin surgery significantly predicted abnormal semen parameters (p=0.025, 0.040 and 0.017, respectively). Positive cultures were recorded in 36.2% of cases and Staphylococcus aureus was the most common. Conclusion. Male factor abnormalities remain significant contributors to infertility and men should be encouraged, through advocacy, to participate in investigations into infertility, to reduce stigmatisation and ostracising of women with infertility, especially in sub-Saharan Africa.

show abstract

Section: Discussionsupporting

confidence: 81%

Factors predictive of abnormal semen parameters in male partners of couples attending the infertility clinic of a tertiary hospital in south-western Nigeria

Aduloju

Adegun

2016

S Afr J OG

View full text Add to dashboard Cite

show abstract

“…Present study recorded significantly decreased sperm quality in infertile men was compared to fertile, concordant to studies of [24,25,26] Lipid peroxidation of sperm membrane is considered to be the key mechanism of ROS induced sperm damage. MDA is byproduct of lipid peroxidation and important marker for oxidative stress.…”

Section: A Comparison Of Age Semen Parameters and Mda Between Fertilsupporting

confidence: 69%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

View full text Add to dashboard Cite

Male infertility is an important medical and psychosocial problem worldwide. Therefore, it is important to identify new and non-conventional factors that may play significant role in male infertility. Current study focused on detecting more risk factors and markers for primary infertility in order to develop interventions for investigation and prevent their progressions. Oxidative stress has recently been identified as an underlying mechanism of numerous sources. The aim of the present study was therefore to evaluate whether there is an association between oxidative stress and male infertility in Erbil city subjects. The present prospective case control study was carried out between March to May 2013, in Maternity Teaching Hospital/in-vitro fertilization center and private clinical laboratory. 75 infertile males represent patients group were enrolled in this study. Apparently 40 healthy individuals who have no history of clinical evidence of any disease were also joined to this study as control group. Malondialdehyde (MDA), the marker of lipid peroxidation was measured in the seminal fluid of fertile and infertile male subjects. The sperm count, sperm morphology and motility, as well as semen volume were all found significantly lower in infertile subjects compared with fertile subjects (p<0.01). In seminal plasma, the MDA level was found significantly higher in infertile group (p<0.05). Lifestyle behaviours such as varicocele repair, cigarette smoking and alcohol consumption, all enhance the generation of ROS level in the seminal plasma, such elevation associated with decreased sperm quality particularly in term of sperm count and sperm motility that leading to increase male infertility.

show abstract

“…The degree of infertility and its cause vary from place to place. These are evident from the study pursued in mid-Western Nigeria which brought to the lime light that about 50%, of the 780 couples under evaluation, differed in the causes of their infertility 41 . Study associated with South-Western Nigeria reported that 42.4% infertility resulted from the male factor 42 .…”

Section: Data Extraction and Data Anaysismentioning

confidence: 99%

Evidence for decreasing sperm count in African population from 1965 to 2015

Sengupta¹,

Nwagha²,

Dutta³

et al. 2017

Afr H. Sci.

View full text Add to dashboard Cite

Purpose: This meta-analysis, following our previous reports those documented an overall 57% diminution in mean sperm concentration around the globe over past 35 years and 32.5% decline in past 50 years in European population, attempts to report the declining trend of sperm concentrations in African population between 1965 and 2015. Methods: In the course of retrieval of data following MOOSE guidelines and PRISMA checklist, we found a total of fourteen studies that have been conducted during that period on altering sperm concentration in the African male. Results: Following analysis of the data, a time-dependent decline of sperm concentration (r = -0.597, p = 0.02) and an overall 72.6% decrease in mean sperm concentration was noted in the past 50 years. The major matter of concern is the present mean concentration (20.38×10 6 /ml) is very near to WHO cut-off value of 2010 of 15×10 6 /ml. Several epidemic diseases, genital tract infection, pesticides and heavy metal toxicity, regular consumption of tobacco and alcohol are reported as predominant causative factors. Conclusion: This comprehensive, evidence-based meta-analysis and systematic review concisely presents the evidence of decreased sperm concentration in the African male over past 50 years with possible causative factors to serve the scientific research zone related to male reproductive health.

show abstract

A case-control study of risk factors for male infertility in Nigeria

Abstract: INFERTILITY is associated with various proxies of sexually transmitted infections (STIs) and poor healthcare-seeking behavior for STIs in Nigerian men.

Cited by 43 publications

References 7 publications

Factors predictive of abnormal semen parameters in male partners of couples attending the infertility clinic of a tertiary hospital in south-western Nigeria

Factors predictive of abnormal semen parameters in male partners of couples attending the infertility clinic of a tertiary hospital in south-western Nigeria

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

Evidence for decreasing sperm count in African population from 1965 to 2015

Contact Info

Product

Resources

About