A case-control study of malignant and non-malignant respiratory disease among employees of a fiberglass manufacturing facility.

Abstract

A case-control study was conducted to determine the influence of non-workplace factors on risk of respiratory disease among workers at the Owens-Corning Fiberglas plant in Newark, Ohio. Cases and controls were drawn from a historical cohort mortality study conducted on behalf of the Thermal Insulation Manufacturers Association (TIMA) of workers employed at Newark for at least one year between 1 January 1940 and 31 December 1963 and followed up to the end of 1982. The TIMA study reported a statistically significant increase in respiratory cancer (compared with national death rates). Interviews were completed for 144 lung cancer cases and 299 matching controls and 102 non-malignant respiratory disease cases and 201 matching controls. Unadjusted odds ratios (ORs) were used to assess the association between lung cancer or non-malignant respiratory disease and birthplace, education, income, marital state, smoking with a duration of six months or more, age at which smoking first started, and duration of smoking. Only the smoking variables were statistically significant. For lung cancer, of the variables entered into a conditional logistic regression model, only the smoking OR of 23.4 (95% CI 3.2-172.9) was statistically significant. For non-malignant respiratory disease no variables entered into the final model were statistically significant. Results of the interview portion of our case-control study clearly indicate that smoking is the most important non-workplace factor for risk of lung cancer in this group of workers. Smoking does not seem to play as important a part, however, for non-malignant respiratory disease. Prevalence of cigarette smoking at the Newark plant was estimated for birth cohorts by calendar year. Corresponding data for the United States were compiled from national smoking surveys. Prevalence of cigarette smoking for Newark in 1955 appears to be sufficiently greater than the corresponding United States data in 1955 to suggest that some of the previously reported excess of lung cancer for Newark based on United States mortality may be accounted for by differences in the prevalence of cigarette smoking between white men in Newark and those in the United States as a whole.

Respiratory health effects of man-made vitreous (mineral) fibres

“…More recent studies [123,132] have confirmed the absence of any relationship between respiratory symptom/loss of pulmonary function and exposure to MMVF. CHIAZZE et al [132] demonstrated that only the smoking variable was significantly associated with nonmalignant respiratory disease.…”

“…More recent studies [123,132] have confirmed the absence of any relationship between respiratory symptom/loss of pulmonary function and exposure to MMVF. CHIAZZE et al [132] demonstrated that only the smoking variable was significantly associated with nonmalignant respiratory disease. The last follow-up of the USA cohort study [34] found no evidence of a relationship between MMVF exposure and deaths from nonmalignant respiratory disease.…”

Review of Smoke Toxicity of Fiber-Polymer Composites Used in Aircraft

“…A reason for glass fibers not being a serious health hazard is they are rapidly dissolved by alveoli macrophages, particularly when under 10-20 m [83,85,89]. For example, Eastes and Hadley [85] showed that a 1-m-diam fiber of glass wool dissolves in a rat lung within about 50 days, whereas complete dissolution by macrophages of chrysotile fibers and crocidolite asbestos fibers of the same size takes 7 and 52 years, respectively.…”

“…A large number of toxicology and epidemiology studies have been performed on the inhalation of virgin glass fibers, and all found no serious adverse health effects [83][84][85][86][87][88][89][90]. These studies were performed using fiber doses and exposure times that are much higher than for an aircraft fire.…”

The occupational physician's point of view: the model of man-made vitreous fibers.

“…This is particularly needed for the Environmental Health Perspectives rockwool and slagwool group. In addition, discussions concerning the influence of the confounding factors on the available results are not closed (7)(8)(9)(10). In any case, two points have to be reassessed: First, industrial hygiene data suggest that the level of exposure could be higher among end-users than among workers in the manufacturing industry (11); and second, due to the short survey period on the one hand and, on the other, the relatively small number of person-years in the groups derived from workers for whom the duration since the beginning of exposure was more than 30 years, it would not be possible to detect a low but significant excess risk of mesothelioma on the basis of the available data.…”