A Case-Control Study of Dementia of the Alzheimer Type

French, L. R.; Schuman, Leonard M.; Mortimer, James A.; Hutton, J. Thomas; Boatman, Regmina; Christians, B

doi:10.1093/oxfordjournals.aje.a114013

Cited by 238 publications

(97 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Methods of exposure determination in these studies vary, ranging from proxy reports [22][23][24] to self-administered mail-in questionnaires 25 to structured in-person interviews. 2,24 Determination of the level of occupational pesticide exposure is particularly difficult because it depends on the duration of use, the method of application, and whether safety equipment was used, or used properly.…”

Section: 21-25mentioning

confidence: 99%

“…Results of investigations into the reliability of data collection methods used in the Agricultural Health Study 27 suggest that our methods may be more accurate than those applied in studies that use mail back questionnaires 25 and reports from proxy informants which were necessarily used in case-control studies. [22][23][24] The Agricultural Health Study analysis showed that structured questionnaires with cues yield better information than open-ended questioning. 27 Farmers' self-reported pesticide use has shown good reliability 27,29 regardless of the age or education level of participants.…”

Section: 21-25mentioning

confidence: 99%

See 1 more Smart Citation

Occupational exposure to pesticides increases the risk of incident AD

Hayden¹,

Norton²,

Darcey³

et al. 2010

Neurology

312

169

View full text Add to dashboard Cite

show abstract

Section: 21-25mentioning

confidence: 99%

Section: 21-25mentioning

confidence: 99%

Occupational exposure to pesticides increases the risk of incident AD

Hayden¹,

Norton²,

Darcey³

et al. 2010

Neurology

312

169

View full text Add to dashboard Cite

show abstract

“…We excluded reviews, editorials, nonhuman studies, and case reports; we also excluded publications that explored the association between serum pesticide levels and risk of AD, as these data could not be meta-analysed because of their different formats in the reporting of results. After excluding those studies that failed to meet the inclusion criteria, a total of seven publications were selected, providing data on three cohort 12,17,18 and four case-control studies [19][20][21][22] . The flowchart of literature selection is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Effects of Detraining on Ach, AchE, β-amyloid, Apolipoprotein Expression and Cognitive Function in Brain Tissue of Memory Impairment Rats

정¹,

박²,

윤³

2017

Exerc Sci

View full text Add to dashboard Cite

Evidence suggests that lifelong cumulative exposure to pesticides may generate lasting toxic effects on the central nervous system and contribute to the development of Alzheimer's disease (AD). A number of reports indicate a potential association between long-term/low-dose pesticide exposure and AD, but the results are inconsistent. Therefore, we conducted a meta-analysis to clarify this association. Relevant studies were identified according to inclusion criteria. Summary odds ratios (ORs) were calculated using fixed-effects models. A total of seven studies were included in our meta-analysis. A positive association was observed between pesticide exposure and AD (OR = 1.34; 95% confidence interval [CI] = 1.08, 1.67; n = 7). The summary ORs with 95% CIs from the crude and adjusted effect size studies were 1.14 (95% CI = 0.94, 1.38; n = 7) and 1.37 (95% CI = 1.09, 1.71; n = 5), respectively. The sensitivity analyses of the present meta-analysis did not substantially modify the association between pesticide exposure and AD. Subgroup analyses revealed that high-quality studies tended to show significant relationships. The present meta-analysis suggested a positive association between pesticide exposure and AD, confirming the hypothesis that pesticide exposure is a risk factor for AD. Further highquality cohort and case-control studies are required to validate a causal relationship.Alzheimer's disease (AD) is the most common progressive neurological disease and results in an irreversible loss of neurons 1 . Late-onset AD, which typically develops after age 60, is the most common form and is characterized by the insidious onset of dementia, progressive memory loss, and cognitive decline ultimately leading to dysfunction in daily life and work abilities 2 . Pathologically, amyloid plaques and neurofibrillary tangles are the main forms of aggregated proteins involved in AD. Amyloid plaques are visible protein aggregates derived from the dimers and oligomers of brain amyloid-β protein, while neurofibrillary tangles are composed of a compact filamentous network of helical filaments of hyperphosphorylated tau protein. Together these neuropathological changes are thought to result in the loss of synapses and neuronal cell death, leading in cognitive dysfunction 3,4 . The aetiology of late-onset AD remains largely unknown but is believed to be multifaceted, resulting from both genetic and environmental factors 5 . The main risk factor is clearly age, though research has identified some genetic risk factors that may account for a small percentage of AD cases 6 . The most well established genetic component of AD risk is the APOE-ε 4 allele 7,8 . Epidemiological studies have reported a higher prevalence of AD in rural areas than in urban settings. Over the past decades, pesticides have been used to increase the productivity and the specialization of cultures in rural areas 9 . Evidence from in-vitro models and animal studies suggests that long-term/low-dose pesticide exposure may lead to the neuronal loss in specific brain regi...

show abstract

“…169 The moderate consumption of alcoholic beverages, however, has been associated with comparatively better cognitive function in two studies: The Zutphen Elderly Study 170 and the Honolulu Asia Aging Study. 171 A third study, The Rotterdam Study, demonstrated that moderate alcohol consumption reduced the risk of vascular dementia in particular, and also that of Alzheimer's disease in individuals aged 55 years or older, 172 which is supported by the results of other studies by Huangand colleagues 173 and Mukamal and colleagues.…”

Section: Effect Of Wine On Alzheimer's Disease and Dementiamentioning

confidence: 99%

Is there a role for wine in cancer and the degenerative diseases of aging?

Stockley¹

2009

IJWR

View full text Add to dashboard Cite

Population aging is associated with the increased incidence cancer and of degenerative diseases. Population aging is occurring on a global scale, with faster aging projected for the coming decades than has occurred in the past. Globally, the population aged 60 years and over is projected to nearly triple by 2050, while the population aged 80 years and over is projected to experience a more than fivefold increase. Increased numbers of older individuals may have implications for associated expenditure on income support, housing and health services, although a healthy, independent older population can also form a valued social resource, for example in providing care for others, sharing skills and knowledge, and engaging in volunteer activities. Simple dietary measures such as moderate wine consumption to supplement a healthy exercise and nutrition routine, or as an adjunct to prescription medicines when appropriate, are thus needed to maintain an aging population. The role of wine in cancer and the degenerative diseases of aging is thus discussed.

show abstract

A Case-Control Study of Dementia of the Alzheimer Type

Cited by 238 publications

References 0 publications

Occupational exposure to pesticides increases the risk of incident AD

Occupational exposure to pesticides increases the risk of incident AD

Effects of Detraining on Ach, AchE, β-amyloid, Apolipoprotein Expression and Cognitive Function in Brain Tissue of Memory Impairment Rats

Is there a role for wine in cancer and the degenerative diseases of aging?

Contact Info

Product

Resources

About