A Case-control Study of Community-associated Clostridium difficile Infection: No Role for Proton Pump Inhibitors

A prospective study of community-associated Clostridium difficile infection in Kuwait: Epidemiology and ribotypes

“…However, the same group a year later did not find any significant association [8], which is similar to our finding.…”

Clostridium difficilevirulence factors: Insights into an anaerobic spore-forming pathogen

“…C. difficile gains a foothold in the host when the gut microbiota is disturbed, usually as a result of antibiotic therapy that is administered for an unrelated condition although this does not always appear to be the case in community acquired CDI. 8 After entering the host in the spore form C. difficile passes through the stomach into the small intestine, where it begins the germination process, eventually transitioning into the metabolically active vegetative cell form. Colonisation and proliferation, which are likely to involve numerous surface structures and adhesins, predominantly occurs in the suitably anaerobic environment of the descending colon.…”

Statins andClostridum difficile: a clinically relevant interaction?

“…Motzkus-Feagans and colleagues7 suggest that statin use may be protective against another infection, hospital acquired Clostridium difficile ; a similar protective effect was also reported in a study of community acquired C difficile infection 8. Neither of these studies adjusted for any of these healthy user variables.…”