A Case-Control Study of Colorectal Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption in Saitama Prefecture, Japan.

Hoshiyama, Yoshiharu; Sekine, Takeshi; Sasaba, Takafumi

doi:10.1620/tjem.171.153

Cited by 81 publications

(58 citation statements)

References 29 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Japan, several case-control studies have been conducted in recent years. [15][16][17]30) All but one 30) of these studies found a positive correlation between alcohol consumption and colorectal cancer. Yoshida et al showed that the risk of colon rather than rectal cancer was significantly elevated in alcohol drinkers, but sub-sites of the colon were not discriminated.…”

Section: Discussionmentioning

confidence: 99%

Genotype Difference of Aldehyde Dehydrogenase 2 Gene in Alcohol Drinkers Influences the Incidence of Japanese Colorectal Cancer Patients

Murata

Tagawa

Watanabe

et al. 1999

Japanese Journal of Cancer Research

View full text Add to dashboard Cite

A case-control study was conducted to explore the possible etiologic role of alcohol and aldehyde dehydrogenase 2 (ALDH2) gene among Japanese colorectal cancer patients. Information on their drinking, smoking and dietary habits was collected from 265 colon and 164 rectum cancer patients, and 794 non-cancer patients as a control group. Genotypes of the ALDH2 gene at codon 487, glutamic acid (ALDH2 * 1) as a wild-type or lysine (ALDH2 * 2) as a mutated type with reduced enzyme activity, were analyzed by polymerase chain reaction in 160 colon and 110 rectum cancer patients and 121 control persons. Univariate analysis with the χ χ χ χ 2 statistical test showed that heavy alcohol drinking (P < < < <0.01), frequent meat intake (P < < < <0.001), and irregular (P < < < <0.01), hasty (P < < < <0.01) and excessive (P < < < <0.001) eating habits were associated with the incidence of both colon and rectum cancers, whereas heavier smoking (P < < < <0.05) and infrequent fish (P < < < <0.03) and fruit (P < < < <0.01) intake were solely associated with incidence of rectum cancer. Infrequent green vegetable intake was not correlated with the incidence of colorectal cancer. Multivariate unconditional logistic regression analysis confirmed the association of alcohol consumption (P < < < <0.01) and meat intake (P < < < <0.05).Homozygous and heterozygous carriers of ALDH2 * 2 allele tended to be found in colon (trend P = = = =0.04) but not in rectum cancer patients compared to controls. Risk elevation for colon cancer due to alcohol consumption was pronounced among the heterozygotes and it was statistically significant especially for distal colon cancer (trend P = = = =0.02). We conclude that alcohol consumption is a risk factor for colorectal cancer and the risk can be enhanced in ALDH2 heterozygotes.

show abstract

Section: Discussionmentioning

confidence: 99%

Genotype Difference of Aldehyde Dehydrogenase 2 Gene in Alcohol Drinkers Influences the Incidence of Japanese Colorectal Cancer Patients

Murata

Tagawa

Watanabe

et al. 1999

Japanese Journal of Cancer Research

View full text Add to dashboard Cite

show abstract

“…Michels et al (36) reported separate RR from two large US cohorts in their study, the Nurses' Health Study (NHS) (36a) and the Health Professionals Follow-up Study (HPFS) (36b) ; we counted the report as two prospective studies. Finally, our meta-analysis included twenty-five case-control (11,15,20,26,(28)(29)(30)(31)(33)(34)(35)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51) and sixteen cohort studies (17,19,21-25,27,32,36a,36b,37,52-55) .…”

Section: Inclusion Criteriamentioning

confidence: 99%

Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies

Ma²,

Zhang³

et al. 2012

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Separate meta-analyses based on case-control and cohort studies have reported different results on the relationship between coffee consumption and colorectal cancer risk. To clarify the effect of coffee intake on colorectal cancer risk, we performed a meta-analysis based on both case-control and cohort studies. Design: Review study. Setting: We identified case-control and cohort studies related to coffee consumption and colorectal cancer risk listed on MEDLINE, the Cochrane Controlled Trials Register, EMBASE, Science Citation Index and PubMed (until May 2011). In subgroup analyses using case-control studies, significant inverse associations were found in females for colorectal cancer and in Europe for colorectal and colon cancer, while the subgroup analyses of cohort studies found that coffee drinks substantially decreased risk of colon cancer only in Asian women. Conclusions: Results from case-control studies suggest coffee consumption can significantly decrease the risks of colorectal cancer and colon cancer, especially in Europe and for females. Keywords Colorectal cancer Coffee Meta-analysis Observational studiesColorectal cancer is the third most common cancer in men and the second most common in women worldwide, with over 1?2 million new cancer cases and 608 700 deaths occurring in 2008 (1) . It is well known that obesity, smoking and physical inactivity are important risk factors for colorectal cancer. However, nutritional factors such as alcohol, tea, coffee, etc. have also been considered to play an important role in the development of colorectal cancer (2) .Coffee is a complex mixture of more than a thousand chemicals, and these constituents have potential genotoxic and mutagenic properties, antioxidant and antimutagenic activities to affect colorectal cancer risk (3) . Over the last four decades, the relationship between coffee consumption and colorectal cancer risk has been extensively examined (4) . In 1990, a Working Group of the International Agency for Research on Cancer reviewed the data on coffee consumption and colorectal cancer risk and concluded that in man 'there is some evidence of an inverse relation between coffee drinking and cancer of the large bowel' (3) . However, the relationship between coffee intake and colorectal cancer risk appears inconsistent in case-control studies and cohort studies. To clarify the relationship between coffee consumption and colorectal cancer risk, Giovannucci performed a meta-analysis in 1998 and reported an overall OR/relative ratio (RR) for high v. low coffee intake of 0?72 (95 % CI 0?61, 0?84) and 0?97 (95 % CI 0?73, 1?29) after combining the results of twelve case-control studies and five cohort studies, respectively (5) . A subsequent meta-analysis (6) and a pooled analysis (7) for cohort studies showed no significant inverse associations; however, another meta-analysis in 2011 *Corresponding authors: Email

show abstract

“…Michel et al (1996) reported that the characteristic fermentation pattern associated with the fiber from the three brown algae they investigated was attributable to the peculiar fermentation of alginates, and mannuronate was shown not to be directly involved. As for the relationship of seaweed consumption to carcinogenesis, several reports have shown preventive effects of seaweeds against colorectal carcinogenesis in epidemiological studies (Tokudome et al, 1991;Hoshiyama et al, 1993), or in experimental studies in rats (Yamamoto and Maruyama, 1985;Teas et al, 1998); proposed mechanisms for such effects include inhibition of reactive oxygen species (Maruyama et al, 2003;Suzuki et al, 2004), or the modulation of natural killer cell activity (Teas, 1983). Furthermore, there are several reports regarding the preventive effect of seaweed consumption against breast cancer (Teas, 1983;Kang et al, 2004).…”

Section: Fiber Intake Pattern S Fukuda Et Almentioning

confidence: 99%

Pattern of dietary fiber intake among the Japanese general population

et al. 2006

View full text Add to dashboard Cite

Objectives: To evaluate the dietary fiber (DF) intake pattern among the Japanese general population. Design: We performed a dietary survey among the general population in northern Japan to evaluate the intake patterns. DF intake was calculated by substituting the DF content of each food in the Dietary Fiber Table for the intake of each food from this dietary survey. Subjects: Five hundred and seventy-seven subjects participated in the study, 198 men and 379 women. Results: In subjects with higher DF intakes the origins of the DF that were from all food groups, but with the notable exception of rice. The contribution of the seaweed group was of particular interest. From multiple regression analysis, as for food group, seaweeds showed the highest positive correlation with DF intake in both genders, followed by vegetables, pulses, fruits. On the other hand, rice showed the negative correlation with DF intake in both genders. As for life factor, body mass index showed the negative correlation with DF intake in women. Conclusion: Seaweed, a typical Japanese food, was most related to the increase in DF intake for the Japanese general population, whereas rice, the Japanese staple, had a small influence on decreased DF intake.

show abstract

A Case-Control Study of Colorectal Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption in Saitama Prefecture, Japan.

Cited by 81 publications

References 29 publications

Genotype Difference of Aldehyde Dehydrogenase 2 Gene in Alcohol Drinkers Influences the Incidence of Japanese Colorectal Cancer Patients

Genotype Difference of Aldehyde Dehydrogenase 2 Gene in Alcohol Drinkers Influences the Incidence of Japanese Colorectal Cancer Patients

Coffee consumption and risk of colorectal cancer: a meta-analysis of observational studies

Pattern of dietary fiber intake among the Japanese general population

Contact Info

Product

Resources

About