A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan

Wu, Ming–Shiang; Lee, Wei-Jei; Wang, Hsih‐Hsi; Huang, Shu‐Chien; Lin, Jaw–Town

doi:10.1001/archinte.165.13.1552

Cited by 106 publications

(88 citation statements)

References 29 publications

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“…A second possibility is that the ready availability of food in Western culture may obliterate other effects. In East Asian populations, where most people have corpus gastritis and highly interactive strains of H. pylori, obesity has been associated with H. pylori-negativity (117). The hypothesis that modern obesity is due in part to absence of H. pylori, and that the mechanism is through disturbances in gastric hormones, remains unproven but deserves more extensive investigation.…”

Section: Absence Of H Pylori Causes Hyperghrelinemia and Reduced Gasmentioning

confidence: 99%

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications

2009

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Humans have been colonized by Helicobacter pylori for at least 50,000 years and probably throughout their evolution. H. pylori has adapted to humans, colonizing children and persisting throughout life. Most strains possess factors that subtly modulate the host environment, increasing the risk of peptic ulceration, gastric adenocarcinoma, and possibly other diseases. H. pylori genes encoding these and other factors rapidly evolve through mutation and recombination, changing the bacteria-host interaction. Although immune and physiologic responses to H. pylori also contribute to pathogenesis, humans have evolved in concert with the bacterium, and its recent absence throughout the life of many individuals has led to new human physiological changes. These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases.

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Section: Absence Of H Pylori Causes Hyperghrelinemia and Reduced Gasmentioning

confidence: 99%

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications

2009

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show abstract

“…However, the prevalence of H. pylori infection in morbidly obese patients and its effect on ulcer progression or the response to eradication treatments is unresolved [13][14][15][16][17][18]. Furthermore, it is also unclear whether the detection and eradication of H. pylori prior to bariatric surgery can reduce the risk of postoperative peptic ulcer disease [19,20].…”

Section: Discussionmentioning

confidence: 99%

Should endoscopy be routinely performed for bariatric surgery candidates?

Çaycı¹,

Erdoğdu²,

Karaman³

et al. 2016

Eur Res J

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Objectives. The rationale for a routine endoscopy before bariatric surgery in asymptomatic patients remains controversial. The purpose of the present study was to compare, in a retrospective manner, the endoscopic findings of morbidly obese patients awaiting surgery with those of non-obese individuals. Methods. Between January 2014 and December 2014, preoperative endoscopic findings of 161 morbidly obese patients and 101 consecutive non-obese individuals were evaluated. Results. No significant differences were found between the two groups in terms of ulcer prevalence and the number of ulcers (p=0.120 and p=0.122, respectively). However, the frequency of bulbar ulcers was significantly higher in morbidly obese patients than in the nonobese (p=0.012). Furthermore, the ulcer activity score was significantly higher in morbidly obese patients (p=0.025). 84 patients underwent laparoscopic sleeve gastrectomy (LSG). Of those, 48 patients (57.1%) had Helicobacter pylori sero-positivity and 12 patients (14.3%) had peptic ulcer disease before surgery. H. pylori sero-positivity persisted in the resected gastric specimens of 33 patients (39.3%). Conclusion. The ulcer activation score in morbidly obese patients is higher -even when they are asymptomatic-than in non-obese individuals. Routine preoperative endoscopy should be considered in all bariatric surgery candidates to rule out pathologies such as hiatal hernia, extensive ulcers or malignant lesions which are the contraindications for a LSG.Eur Res J 2016;2(2):93-98

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“…The findings of present study are consistent with the report of previous studies that H. pylori infection is inversely related to obesity. For example, Wu et al [26] reported that the seropositivity of H. pylori infection was significantly lower in morbidly obese patients [25]. Furuta et al [9] have shown the body weight gain after H. pylori cure.…”

Section: Discussionmentioning

confidence: 99%

Does Helicobacter pylori eradication effect body composition, dietary intake, serum leptin and ghrelin levels of infected patients?

Somi

Faramarzi

Nagashi³

et al. 2014

Turk J Bioch

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A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan

Abstract: Our data indicated an inverse relationship between morbid obesity and H pylori seropositivity. These findings raise the hypothesis that a lack of H pylori infection, especially during childhood, might enhance the risk of the development of morbid obesity.

Cited by 106 publications

References 29 publications

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications

Coadaptation of Helicobacter pylori and humans: ancient history, modern implications

Should endoscopy be routinely performed for bariatric surgery candidates?

Does Helicobacter pylori eradication effect body composition, dietary intake, serum leptin and ghrelin levels of infected patients?

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