A Case-Control Study of Alzheimer's Disease and Aluminium Occupation

Salib, Emad; Hillier, V.

doi:10.1192/bjp.168.2.244

Cited by 53 publications

(23 citation statements)

References 10 publications

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“…All the studies are casecontrol studies, with a relatively low level of quality according to our classification. For aluminium, one of the three studies about this exposure is the second in the quality ranking of the casecontrol studies 28. Results from this study show no association (aRR0.95, 95 CI 0.5 to 1.9).…”

Section: Resultsmentioning

confidence: 61%

Occupational risk factors in Alzheimers disease: a review assessing the quality of published epidemiological studies

Santibáñez

Bolúmar²,

García³

2007

Occup Environ Med

118

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Epidemiological evidence of an association between Alzheimers disease AD and the most frequently studied occupational exposurespesticides, solvents, electromagnetic fields EMF, lead and aluminiumis inconsistent. Epidemiological studies published up to June of 2003 were systematically searched through PubMed and Toxline. Twenty-four studies 21 casecontrol and 3 cohort studies were included. Median GQI was 36.6 range 19.562.9. Most of the casecontrol studies had a GQI of <50. The study with the highest score was a cohort study. Likelihood of exposure misclassification bias affected 18 of the 24 studies. Opportunity for bias arising from the use of surrogate informants affected 17 studies, followed by disease misclassification 11 studies and selection bias 10 studies. Eleven studies explored the relationship of AD with solvents, seven with EMF, six with pesticides, six with lead and three with aluminium. For pesticides, studies of greater quality and prospective design found increased and statistically significant associations. For the remaining occupational agents, the evidence of association is less consistent for solvents and EMF or absent for lead and aluminium.

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Section: Resultsmentioning

confidence: 61%

Occupational risk factors in Alzheimers disease: a review assessing the quality of published epidemiological studies

Santibáñez

Bolúmar²,

García³

2007

Occup Environ Med

118

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“…Epidemiological studies which examine the prevalence of a toxic encephalopathy as well as Alzheimer and Parkinson diseases in relation to lifetime environmental and occupational Al exposures hardly give references to significant outcomes (e.g. Antonini 2003;Fored et al 2006;Fryzek et al 2005;Graves et al 1998;Salib and Hillier 1996;Savory et al 1996). 3.…”

Section: Models Of Al Neurotoxicitymentioning

confidence: 98%

Longitudinal study on potential neurotoxic effects of aluminium: I. Assessment of exposure and neurobehavioural performance of Al welders in the train and truck construction industry over 4 years

Kiesswetter

Schäper

Buchta³

et al. 2007

Int Arch Occup Environ Health

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Compared to studies in the literature this study is characterized by relatively high and non-confounded Al exposure of the welders, a repeated-measurement design, and multivariate analyses. However, the long-term stable interindividual differences of internal Al exposure were not related to interindividual differences in neurobehavioural performances. Additionally, the lack of processual changes of neurobehavioural performances during the observation phase and the insignificant group differences do not make it very probable that degenerative processes caused by Al had happened before study onset or stopped just at this time point.

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“…Pour les expositions aux pesticides, des effets modérés sur la cognition ont été décrits en transversal avec les fonctions cognitives[89] et chez les hommes de l'étude Paquid avec la maladie d'Alzheimer[90]. Pour les expositions aux métaux lourds et à l'aluminium, les études sont globalement négatives[91][92][93][94][95][96]. Les effets sanitaires de l'aluminium hydrique sur le fonctionnement cognitif ou la présence d'une démence ont été décrits en population générale ou sur des cas hospitaliers.…”

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Épidémiologie des démences

et al. 2007

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Dementia is a major public health problem and its burden will increase in the 30 years to come. Prevalence increases with age and incidence is slightly higher in women than men, especially after the age of 80 years. Survival after the onset of dementia is approximately 5 years. Lifestyle and health habits are a keystone for dementia: risk factors include physical, intellectual and social activity and nutritional habits. Data from well-conducted intervention studies are necessary to show whether better care for hypertension, diabetes, and dyslipidemia might decrease the incidence of dementia.

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A Case-Control Study of Alzheimer's Disease and Aluminium Occupation

Abstract: There is no evidence to support an association between having previously worked in an aluminium factory and the risk of Alzheimer's disease later in life.

Cited by 53 publications

References 10 publications

Occupational risk factors in Alzheimers disease: a review assessing the quality of published epidemiological studies

Occupational risk factors in Alzheimers disease: a review assessing the quality of published epidemiological studies

Longitudinal study on potential neurotoxic effects of aluminium: I. Assessment of exposure and neurobehavioural performance of Al welders in the train and truck construction industry over 4 years

Épidémiologie des démences

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