A case–control study investigating food addiction in Parkinson patients

Chazeron, Ingrid de; Durif, Franck; Lambert, Céline; Chéreau-Boudet, I.; Fantini, María Livia; Marqués, Ana; Derost, Philippe; Debilly, Bérengère; Brousse, Georges; Boirie‌, Yves; Llorca, Pierre Michel

doi:10.1038/s41598-021-90266-8

Cited by 7 publications

(4 citation statements)

References 61 publications

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“…Changes in the quality of the diet may be driven by specific cognitive changes pertaining to food selection or as part of an impulse control disorder, the latter of which may be related to dopaminergic medication (118) . Compulsive eating has been documented in PD, with one case–control study suggesting that 25 % of patients with PD consumed excessive energy compared with 12 % of healthy controls (119) . This can manifest as binge-eating and correlates with the presence of anxiety more strongly than medication type or dose (120) .…”

Section: Whole Body Metabolism In Parkinson's Diseasementioning

confidence: 99%

Parkinson's disease: the nutrition perspective

et al. 2021

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Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and affects about 1% of the population over the age of 60 years in industrialised countries. The aim of this review is to examine nutrition in PD across three domains: dietary intake and the development of PD; whole body metabolism in PD and the effects of PD symptoms and treatment on nutritional status. In most cases, PD is believed to be caused by a combination of genetic and environmental factors and although there has been much research in the area, evidence suggests that poor dietary intake is not a risk factor for the development of PD. The evidence about body weight changes in both the prodromal and symptomatic phases of PD is inconclusive and is confounded by many factors. Malnutrition in PD has been documented as has sarcopaenia, although the prevalence of the latter remains uncertain due to a lack of consensus in the definition of sarcopaenia. PD symptoms, including those which are gastrointestinal and non-gastrointestinal, are known to adversely affect nutritional status. Similarly, PD treatments can cause nausea, vomiting and constipation, all of which can adversely affect nutritional status. Given that the prevalence of PD will increase as the population ages, it is important to understand the interplay between PD, comorbidities and nutritional status. Further research may contribute to the development of interventional strategies to improve symptoms, augment care and importantly, enhance the quality of life for patients living with this complex neurodegenerative disease.

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Section: Whole Body Metabolism In Parkinson's Diseasementioning

confidence: 99%

Parkinson's disease: the nutrition perspective

et al. 2021

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“…As a sensitivity analysis, the meta‐analysis was repeated after excluding 5 studies 17 , 30 , 31 , 32 , 33 that included in the PD groups some patients with ICDs. Similarly, a statistically significant mean difference (2.85; 95% CI, 1.23, 4.46), with higher BIS‐11 total scores in patients with PD compared with control subjects emerged.…”

Section: Resultsmentioning

confidence: 99%

Impulsivity Traits in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Giovannelli

Gavazzi

Noferini

et al. 2023

Movement Disord Clin Pract

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BackgroundIn Parkinson's disease (PD), impulsivity as a personality trait may be linked to the risk of developing impulse control disorders (ICDs) during dopaminergic therapy. However, studies evaluating differences in trait impulsivity between patients with PD and healthy controls or between patients with PD with and without ICDs reported partly inconsistent findings.ObjectivesWe conducted a systematic review and meta‐analysis (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) of studies comparing Barratt Impulsiveness Scale (BIS‐11) scores between patients with PD and healthy controls and between patients with PD with and without ICDs.MethodsEligible studies were identified through a systematic search in 3 databases. Mean differences with 95% confidence intervals (CIs) for BIS‐11 total and subscale scores were separately calculated for studies comparing patients with PD and healthy controls and patients with PD with and without ICDs. Meta‐regressions were performed to explore sources of heterogeneity (percentage of men, age, disease duration, and levodopa equivalent daily dose).ResultsA total of 40 studies were included in the quantitative analyses. BIS‐11 total scores were significantly higher in patients with PD compared with healthy controls (mean difference 2.43; 95% CI, 1.03, 3.83), and in patients with PD with active ICDs compared with patients without ICDs (6.62; 95% CI, 5.01, 8.23). No significant moderators emerged by meta‐regression analyses.ConclusionsThe present meta‐analysis supports that impulsivity, as a personality trait, may characterize patients with PD, even in the absence of ICDs. Moreover, these data corroborate findings of clinical studies reporting higher levels of trait impulsivity in PD patients with ICDs compared with patients without ICDs.

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“…Only one article evaluated the relationship between FA and impulsivity in a 100% male sample [58] of individuals with obesity. Three further articles were identified that included a majority of men (10.3%) [49 In men, associations between FA and cognitive impulsivity, greater lack of planning, and weaker impulse control performance were found [58]. In the studies that had a higher percentage of men in their sample, FA was found to play a mediating role between impulsivity and BMI [56 One study did not detect FA in men [49••], while in another study, FA and impulsivity were not associated with the male gender [88].…”

Section: Impulsivity and Gender Differencesmentioning

confidence: 99%

Food Addiction and Impulsivity in Clinical Populations by Gender: a Systematic Review

Gaspar-Pérez,

Paslakis,

Rosinska

et al. 2023

Curr Addict Rep

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Purpose of Review Food addiction (FA) has been found to be associated with impulsivity, mainly urgency (negative and positive) and lack of perseverance. The present systematic review aimed to identify differences in impulsivity by gender and current implications of treatment regarding FA and impulsivity in clinical populations. The search was conducted in PubMed, Scopus, and Web of Science (WOS) databases, using the following search terms: “food addiction” and “impuls*.” Studies were included if they were written in English, had an observational design (e.g., cross-sectional, longitudinal, case-control), and used a quantitative methodology, without a limited search period to avoid selection bias. Recent Findings We included twenty-nine articles that aimed to examine whether there is a relationship between FA and impulsivity in clinical populations. Looking at gender differences, attentional and motor impulsivity were found to be related to FA in samples of women with obesity, whereas in the only study in a sample of men with obesity, cognitive and non-planning impulsivity appeared to be more associated with FA. Moreover, we identified three studies on the effects of interventions which included motivational, psychosocial, nutritional, and mindfulness components to address impulsivity and FA in cohorts with overweight/obesity and with substance use disorder (SUD). While some studies reported decreased levels of impulsivity, in other studies only FA decreased, and only one study showed significant changes in both FA and impulsivity after treatment. Summary Further research is needed to better understand the association between impulsivity and FA. Specifically, more studies with male populations could provide further evidence on how to better tailor treatment designs.

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A case–control study investigating food addiction in Parkinson patients

Cited by 7 publications

References 61 publications

Parkinson's disease: the nutrition perspective

Parkinson's disease: the nutrition perspective

Impulsivity Traits in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Food Addiction and Impulsivity in Clinical Populations by Gender: a Systematic Review

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