A case-control study evaluating occult blood screening for colorectal cancer with hemoccult test and an immunochemical hemagglutination test.

Saitō, Hiroshi; Soma, Yuko; Nakajima, M.; Koeda, Junichi; Kawaguchi, Hitoshi; Kakizaki, Ryosuke; Chiba, Ryosuke; Aisawa, T.; Munakata, Akihiro

doi:10.3892/or.7.4.815

Cited by 39 publications

(33 citation statements)

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“…Although several studies have compared I-FOBT and G-FOBT (Petrelli et al, 1994;Allison et al, 1996;Saito et al, 2000), few have reported sensitivity estimates based on interval CRCs: Nakama et al (1996) reported values by the traditional method, of 90.9, 83.3, and 71.4% within 1, 2, and 3 years, respectively, using the 1-day Monohaem, immunological test. Zappa et al (2001) used the proportional interval cancer incidence method, and reported 1-and 2-year sensitivity estimates for CRC for 1-day RPHA testing of 89 and 82%, respectively, whereas corresponding estimates for 3-day G-FOBT were 64 and 50%, respectively.…”

Section: Sensitivity Of Latexmentioning

confidence: 99%

“…Sensitivity of G-FOBT for CRC has been reported to be as low as 43-66%, based on a 2-year screening interval (Jensen et al, 1992;Launoy et al, 1997;Moss et al, 1999;Jouve et al, 2001); attempts to increase sensitivity either by rehydration (Church et al, 1997) or by increased reagent concentration (Petrelli et al, 1994;Allison et al, 1996) were associated with unacceptable loss in specificity. Several studies have suggested that immunochemical FOBT (I-FOBT) is more sensitive and specific than G-FOBT Saito et al, 2000;Zappa et al, 2001; Levi et al, 2006;Guittet et al, 2007), requiring no dietary restrictions, and might substantially improve screening cost effectiveness Saito et al, 2000). Further progress in I-FOBT use was made by the introduction of the latex agglutination test (LAT), a quantitative and fully automated test (Yamamoto et al, 1990), which made it possible to choose the positivity cutoff values to optimise the balance between sensitivity and specificity, though the debate about the optimal cutoff point continues (Itoh et al, 1996;Castiglione et al, 2000;Nakama et al, 2001;Edwards, 2005;Vilkin et al, 2005).…”

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confidence: 99%

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Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

Castiglione¹,

Visioli²,

Ciatto³

et al. 2007

Br J Cancer

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We evaluated the sensitivity for colorectal cancer (CRC) of the latex agglutination test (LAT), an immunochemical test routinely used in the Florence District screening programme since 2000. Sensitivity was calculated by the proportional interval cancer incidence method in a population of 27 503 consecutive subjects screened in 2000 -2002, interval cancers being identified by linkage to the Tuscany Cancer Registry files. Sensitivity was calculated overall and by gender, age, time since last negative LAT, CRC site, and rank of screening. Overall 1-and 2-year sensitivity estimates were 80.7 and 71.5%, respectively, suggesting that faecal occult blood testing screening sensitivity may be suboptimal due to testing or programme quality problems. Increasing screening sensitivity might be achieved if the detection rate of advanced adenomas could be increased without unacceptable loss in specificity.

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Section: Sensitivity Of Latexmentioning

confidence: 99%

mentioning

confidence: 99%

Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

Castiglione¹,

Visioli²,

Ciatto³

et al. 2007

Br J Cancer

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“…This has already been used as a population screening test and a reduction in risk of dying from colorectal cancer after screening with this test has been consistently suggested by several studies, although these were observational (Saito et al, 1995(Saito et al, , 2000Saito, 1996;Zappa et al, 1997). In our most recent study, reduction in risk of developing advanced colorectal cancer has additionally been suggested (Nakajima et al, 2003).…”

Section: Sirmentioning

confidence: 92%

Reply: Screening for colorectal cancer with immunological FOBT

Saitō¹,

Nakajima

2004

Br J Cancer

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“…In screening tests, individuals with a positive fecal immunological test (FIT) are referred for colonoscopy (gold standard). However, performance of this test is suboptimal, with sensitivity for CRC and advanced adenomas of 66-87% and 27-38%, respectively, depending on cut-off value used [45][46][47][48]. In addition, screening with FIT results in a substantial number of false positive tests, and as a consequence, unneeded colonoscopies.…”

Section: Colorectal Cancermentioning

confidence: 99%

Application of Fecal Volatile Organic Compound Analysis in Clinical Practice: Current State and Future Perspectives

et al. 2018

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Abstract:Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as non-invasive diagnostic biomarker in clinical medical practice. The spectrum of VOCs, originating from (patho)physiological metabolic processes in the human body and detectable in bodily excrements, such as exhaled breath, urine and feces, harbors a magnificent source of information. Thus far, the majority of studies have focused on VOC analysis in exhaled breath, aiming at identification of disease-specific VOC profiles. Recently, an increasing number of studies have evaluated the usability of VOC present in the headspace of feces in the diagnostic work-up of a wide range of gastrointestinal diseases. Promising results have been demonstrated particularly in those diseases in which microbiota alterations are considered to play a significant etiological role, such as colorectal carcinoma, inflammatory bowel disease, irritable bowel syndrome, celiac disease and infectious bowel diseases. In addition, fecal VOC analysis seems to have potential as a diagnostic biomarker for extra-intestinal diseases, including bronchopulmonary dysplasia and sepsis. Different methods for VOC analysis have been used in medical studies, such as gas-chromatography mass spectrometry, selected-ion flow tube-mass spectrometry, ion-mobility spectrometry, and electronic nose devices. In this review, the available literature on the potential of fecal VOCs as diagnostic biomarker, including an overview of relevant VOC detection techniques, is discussed. In addition, future hurdles, which need to be taken prior to implementation of VOC analysis in daily clinical practice, are outlined.

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A case-control study evaluating occult blood screening for colorectal cancer with hemoccult test and an immunochemical hemagglutination test.

Cited by 39 publications

References 0 publications

Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

Reply: Screening for colorectal cancer with immunological FOBT

Application of Fecal Volatile Organic Compound Analysis in Clinical Practice: Current State and Future Perspectives

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