A case and literature review of orbital microcystic adnexal carcinoma

Brent, A; Deol, Sundeep S.; Vaidhyanath, Ram; Saldanha, Gerald; Sampath, Raghavan

doi:10.1080/01676830.2018.1440607

Cited by 8 publications

(21 citation statements)

References 16 publications

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“…3,6,11,13,14,17,18,24,25,29,35,37,42,47,49,51,52,54,56,59,61,63,64,66,70 Eyelid margin abnormalities presenting with distortion, loss of lashes, and “blepharitis” were documented in 13 of 51 (25%) of cases. 8,11,28,31–33,58,64–66,69…”

Section: Resultsmentioning

confidence: 99%

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Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Cheung

Rabinowitz

Tuluc

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To describe a patient with periocular microcystic adnexal carcinoma (MAC) and to review the clinical presentation, systemic work-up, histopathologic features, and outcome of all previously reported periocular MAC. Methods: A major literature review. PubMed/MEDLINE and Google Scholar databases were searched for all well-documented cases of periocular MAC. Results: The final analysis yielded 93 patients with MAC, 48 (52%) females, 39 (42%) males, and 6 with sex not specified (6%) with an average age of 56 years (range 3 days–95 years). Most tumors were localized to the eyebrow (26/93, 28%) and lower eyelid (20/93, 22%). Of patients with known information, MAC most commonly presented as a nodule (37/68, 54%) or plaque (20/68, 29%) with poorly-defined margins (20/51, 39%) and distortion of eyelid margin (13/51, 25%). Orbital involvement at any point of the disease course was seen in 20 of 93 (22%) patients. An accurate histopathologic diagnosis on initial biopsy was made in 25 of 70 (36%) cases. Initial management included surgical excision (47/93, 51%), Mohs micrographic surgery (17/93, 18%), and excision with frozen section control of margins (8/93, 9%). Aggressive or recurrent MAC was managed with multimodal therapies, including adjuvant radiation (10/34, 29%). The average follow-up after the last treatment was 3 years (median 2, range 0.2–20 years). In total, 33 of 86 (38%) tumors recurred, and 6 of 87 (7%) metastasized. Disease-related mortality occurred in 3 of 79 (4%) of patients. Conclusions: Periocular MAC is frequently misdiagnosed on initial biopsy and has a tendency for recurrence and locally aggressive behavior, highlighting the importance of accurate timely diagnosis, and appropriate management.

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Section: Resultsmentioning

confidence: 99%

“…11,29,61 A non-neoplastic process, such as inflammation and fibrosis was diagnosed in 5 of 70 (7%) cases (Table 2). 11,38,55,58,64…”

Section: Resultsmentioning

confidence: 99%

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Cheung

Rabinowitz

Tuluc

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…efficacy (Table 1). 5,7,8,10,12,14,15,[17][18][19][20][21][22][23][24][25]27,29,30 Chemotherapy has been used in only 4 reported cases showing mixed outcomes. 17,21,25,30 Here, we report a case of an extensive, locally advanced MAC treated by definitive chemoRT resulting in an excellent tumor response and durable disease control.…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, there are reports outlining a potential role for radiation (RT) in the adjuvant and definitive setting. 1,5,7,8,10,12,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] The role of chemotherapy is unclear, as there are only a few cases reported with mixed results. 17,21,25,30 Additional investigation into nonsurgical treatment modalities Sources of support: No external funding was received for this manuscript.…”

Section: Introductionmentioning

confidence: 99%

Microcystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature

Kim

Lee

Lam

et al. 2020

Advances in Radiation Oncology

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“…Other sites, such as scalp [11], axilla [8,12], and trunk [13] can also be involved. Interestingly, MAC rarely occurs on the tongue or other oral mucosal tissues [14,15]. So far, no involvement of the anterior-ventral part of the tongue has been reported.…”

Section: Introductionmentioning

confidence: 99%

Microcystic adnexal carcinoma: report of rare cases

et al. 2020

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Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive malignant neoplasm that derives from cutaneous eccrine/apocrine glands. MAC is classified as an eccrine/apocrine gland tumor and usually occurs in the skin. Here, we characterized and compared two cases of MAC. One is extremely rare in terms of its occurrence in the tongue. The other occurred in the lip, which is common. Histories of disease, diagnosis, and differentials were reviewed by the attending physicians. Hematoxylin and Eosin (HE) slides were evaluated by an experienced pathologist. Immunological markers for malignant eccrine/apocrine gland tumors were used to characterize the tumor’s nature. The examined markers included EMA, CK5/6, CK8/18, CK7, CK20, p63, S-100, Calponin, CD10, MYB, Bcl-2, Her-2, CD34, SMA, p53, CD43, CD117, and Ki-67. Both patients were males, presented with painless lumps in the lower lip and in the tongue, respectively. Both lumps were similar in terms of appearance, being whitish, and infiltrative with irregular borders. Both tumors also had similar histological features with nests of bland keratinocytes, cords, and ductal differentiation filled with Periodic acid–Schiff (PAS)-positive eosinophilic material. In both cases, circular or ovary tumor cells invaded into muscles and nerves. All tumor cells were CK5/6, CK8/18, EMA, and CK7 positive. Particularly, keratinocytes were p63 positive, and paraductal cells were p63, S-100, and SMA positive. Therefore, the rare case of MAC in the tongue appears to derive from the salivary gland.

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A case and literature review of orbital microcystic adnexal carcinoma

Cited by 8 publications

References 16 publications

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review

Microcystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature

Microcystic adnexal carcinoma: report of rare cases

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