A cascade-reaction enabled synergistic cancer starvation/ROS-mediated/chemo-therapy with an enzyme modified Fe-based MOF

Liu, Zongjun; Li, Tuo; Han, Fangfang; Wang, You; Gan, Yang; Shi, Junhui; Wang, Tianran; Akhtar, Muhammad; Li, Yu

doi:10.1039/c9bm00641a

Cited by 81 publications

(53 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Photodynamic therapy produces singlet oxygen to strengthen the efficacy of paclitaxel-based chemotherapy 18 . Among others, the combination of starving therapy and chemotherapy is promising for realizing an optimal therapeutic effect due to the different mechanism of the two modalities 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

View full text Add to dashboard Cite

Rationale: Nanoscale vehicles responsive to abnormal variation in tumor environment are promising for use in targeted delivery of therapeutic drugs specifically to tumor sites. Herein, we report the design and fabrication of self-accelerating H 2 O 2 -responsive plasmonic gold nanovesicles (GVs) encapsulated with tirapazamine (TPZ) and glucose oxidase (GOx) for synergistic chemo/starving therapy of cancers. Methods: Gold nanoparticles were modified with H 2 O 2 -responsive amphiphilic block copolymer PEG 45 - b -PABE 330 by ligand exchange. The TPZ and GOx loaded GVs (TG-GVs) were prepared through the self-assembly of PEG 45 - b -PABE 330 -grafted nanoparticles together with TPZ and GOx by solvent displacement method. Results: In response to H 2 O 2 in tumor, the TG-GVs dissociate to release the payloads that are, otherwise, retained inside the vesicles for days without noticeable leakage. The released GOx enzymes catalyze the oxidation of glucose by oxygen in the tumor tissue to enhance the degree of hypoxia that subsequently triggers the reduction of hypoxia-activated pro-drug TPZ into highly toxic free radicals. The H 2 O 2 generated in the GOx-catalyzed reaction also accelerate the dissociation of vesicles and hence the release rate of the cargoes in tumors. The drug-loaded GVs exhibit superior tumor inhibition efficacy in 4T1 tumor-bearing mice owing to the synergistic effect of chemo/starvation therapy, in addition to their use as contrast agents for computed tomography imaging of tumors. Conclusion: This nanoplatform may find application in managing tumors deeply trapped in viscera or other important tissues that are not compatible with external stimulus (e.g. light).

show abstract

Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

View full text Add to dashboard Cite

show abstract

“…In vitro and in vivo experiments demonstrated that a biocatalytic MOF-enabled prominent therapeutic efficacy was achieved by starvation/ROS-mediated/chemotherapy. [108] Another paradigm was illustrated by Zhang and co-workers. [34] Due to the positively charged metal ions in the MOF, it can easily bind to the negatively charged cell membrane, thus facilitating efficient endocytosis.…”

Section: Catalytic Nanomedicinementioning

confidence: 99%

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Liang

2020

Adv Funct Materials

View full text Add to dashboard Cite

Biocatalytic metal-organic framework (MOF) composites, synthesized by interfacing MOFs with biocatalytic components, possess the unprecedented synergetic properties that is hard to achieve by the conventional strategies, represents one of the next-generation composite materials for diverse biotechnological applications. Until now , research on the applications of biocatalytic MOFs is still in its preliminary stage, with a wide variety of studies being focusing on the bioprotection role of MOFs. However, their diversity of building units, molecular-scale tunability, modular synthetic routes, and more detailed understanding of the heterogeneous MOF-biointerface could even lead to completely new applications and potentials beyond our current imagination. The most recent rapid advanced progress in biocatalytic MOFs present ground-breaking applications in smart and tunable biocatalysis, precision nanomedicine, vaccine and gene delivery, biosensing and nano-biohybrids. Herein, the general and advanced synthesis strategies for improving the materials properties of biocatalytic MOFs, from tuning biocatalytic activity to framework stability to synergistic properties with other materials, are summarized. Then, the latest state-of-the-art applications of the biocatalytic MOF systems and recent advanced developments that are shaping this emerging field are surveyed. Finally, to define promising research directions, a critical evaluation and future prospects for the potential applications of biocatalytic MOFs are provided.

show abstract

“…Of course, there are also some chemotherapeutic drugs that are used directly in combination with starvation therapy, such as CPT, [ 50 ] paclitaxel (PTX), [ 76 ] and DOX. [ 72,77 ] For instance, GOx and the anticancer drug PTX were loaded in a multifunctional mesoporous silica nanoparticle that was coated with poly ( l ‐lysine) and HA for synergistic cancer starvation and chemistry therapy.…”

Section: Gox‐instructed Cancer Therapiesmentioning

confidence: 99%

Glucose Oxidase‐Related Cancer Therapies

Wang

Yang

Dong

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

Glucose oxidase (GOx), which catalyzes the conversion of glucose into gluconic acid and hydrogen peroxide (H 2 O 2) in the presence of oxygen (O 2), has aroused growing interest for cancer therapy. GOx can starve tumor cells to death by depleting glucose, which is very important for their energy supply, and the generated H 2 O 2 is can be used for oxidation therapy. In addition, GOx-catalyzed glucose oxidation exerts a variety of effects on the tumor environment, such as enhancing hypoxia and increasing acidity. The full use of these characteristics can effectively reduce side effects and enhance the therapeutic efficiency of GOx-related cancer therapies. As is generally acknowledged, it is difficult to completely eliminate tumors with a single treatment, whereas combining two or more therapies may yield super-additive results because when properly designed, different treatments can compensate for the shortcomings of the other treatments and bring out the best in each other. In view of these facts, enhanced therapies and combination therapies related to glucose oxidation have been widely studied, and this review provides a systematic overview of recent research on GOx-related cancer therapies (especially starvation therapy) from the perspective of glucose oxidation (including the reaction itself, oxygen, enzymes, gluconic acid, and H 2 O 2) and other combination therapies.

show abstract

A cascade-reaction enabled synergistic cancer starvation/ROS-mediated/chemo-therapy with an enzyme modified Fe-based MOF

Abstract: A cascade-reaction enabled synergistic starvation/ROS-mediated/chemo-therapy was developed, and it exhibits a remarkable therapeutic efficacy without any external intervention.

Cited by 81 publications

References 57 publications

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Glucose Oxidase‐Related Cancer Therapies

Contact Info

Product

Resources

About

A cascade-reaction enabled synergistic cancer starvation/ROS-mediated/chemo-therapy with an enzyme modified Fe-based MOF

Abstract: A cascade-reaction enabled synergistic starvation/ROS-mediated/chemo-therapy was developed, and it exhibits a remarkable therapeutic efficacy without any external intervention.

Cited by 81 publications

References 57 publications

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Glucose Oxidase‐Related Cancer Therapies

Contact Info

Product

Resources

About

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors