“…According to latest research, scientists have successfully knocked out 11 ApiAP2 transcription factors in P. falciparum and have gained a preliminary insight into their functions ( Shang et al, 2021 ; Singh et al, 2021 ). PfAP2-G is recognized as the master positive regulator of sexual conversion between gametocyte commitment and development, while PfAP2-G5 and PfAP2-G2 work together as transcriptional repressors ( Kafsack et al, 2014 ; Sinha et al, 2014 ; Poran et al, 2017 ; Xu et al, 2020 ; Shang et al, 2021 ; Singh et al, 2021 ). Another ApiAP2 family member, which is named PfAP2-I, has been reported to regulate the process of invasion ( Santos et al, 2017 ).…”