A cascade nanozyme with antimicrobial effects against nontypeable Haemophilus influenzae

Abstract

A cascade nanozyme with glucose oxidase and haloperoxidase activities was designed and synthesized, which was shown to generate antiseptic HOBr from a ubiquitous non-ROS, O2. It successfully inhibited growth of a bacterial pathogen and its biofilm.

Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

“…These nanozymes presented improved biofilm penetration and generated HOBr in internal structures of EPS matrix, which led to reduction of 58.80% in the count of live cells embedded in biofilms. [167] In contrast to the functional nanomaterials mentioned in this section, nanozymes with the ability to disrupt biofilms and penetrate may be less effective. As reported, it took nearly 24 h for hollow MnO x nanozymes to degrade matrix components by generating ROS to cross biofilms, while these nanozymes loaded with indocyanine green with photothermal effects achieved quick penetration within 30 min.…”

“…These nanozymes presented improved biofilm penetration and generated HOBr in internal structures of EPS matrix, which led to reduction of 58.80% in the count of live cells embedded in biofilms. [ 167 ]…”

A wheel-like polyoxometalate for haloperoxidase-inspired antibiofouling with H2O2in situ provided by electrocatalysis

“…[15][16][17] Artificial nanozymes are ideal substitutes for natural enzymes, including vanadium haloperoxidases. 18 They inherit benign biocompatibility and catalytic functionalities from natural enzymes. What is more important, nanozymes also exhibit good chemical stability, structural plasticity and tunable activity as nanomaterials.…”

“Three-in-one” platform based on Fe-CDs nanozyme for dual-mode/dual-target detection and NIR-assisted bacterial killing

“…[1][2][3] Different from natural enzymes, nanozymes are superior thanks to their simple preparation, high stability under harsh conditions, and adjustable catalytic activity, making them the ''new darlings'' of researchers. 4 Since the first reported nanozyme of Fe 3 O 4 nanoparticles (NPs) with peroxidase (POD)-like activity in 2007, 5 various nanozymes that mimic the activities of transferases, hydrolases, lyases, oxidoreductases and isomerase have been reported. [6][7][8][9][10] In particular, POD-like nanozymes have received wide interest in biosensing, bioremediation and therapy thanks to their unique catalytic ability to produce OH with high reactivity in the presence of hydrogen peroxide (H 2 O 2 ).…”