A cascade nanoplatform for intelligent response to tumor microenvironment and collaborative cancer therapy

Li, Tong; Rong, Mingjie; Wang, Yuzhu; Sun, Wenbo; Lu, Lehui

doi:10.1039/d3tb02879h

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02879h

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A cascade nanoplatform for intelligent response to tumor microenvironment and collaborative cancer therapy

Tong Li,

Mingjie Rong,

Yuzhu Wang

et al.

Abstract: Disulfiram (DSF), a new potential anticancer drug, has been shown to exhibit anticancer activity dependent on the formation of CuET, the chelation product of DSF with Cu2+. However, the poor...

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Sun,

Zhang

et al. 2024

Adv Healthcare Materials

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Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species (ROS)‐mediated cancer therapies, exhibiting its potential as a sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions and hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals (•OH). Its notable advantages in cancer treatment have been demonstrated, including tumor specificity, autonomy from external triggers, and a favorable side‐effect profile. Recent advancements in nanomedicine have been devoted to enhancing CDT, promising a comprehensive optimization of CDT efficacy. This review systematically elucidates cutting‐edge achievements in chemodynamic nanotherapeutics, exploring strategies for enhanced Fenton or Fenton‐like reactions, improved tumor microenvironment modulation, and precise regulation in energy metabolism. Moreover, a detailed analysis of diverse CDT‐mediated combination therapies is provided. Finally, the review concludes with a comprehensive discussion of the prospects and intrinsic challenges to the application of chemodynamic nanotherapeutics in the domain of cancer treatment.This article is protected by copyright. All rights reserved

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Sun,

Zhang

et al. 2024

Adv Healthcare Materials

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A cascade nanoplatform for intelligent response to tumor microenvironment and collaborative cancer therapy

Abstract: Disulfiram (DSF), a new potential anticancer drug, has been shown to exhibit anticancer activity dependent on the formation of CuET, the chelation product of DSF with Cu2+. However, the poor...

Cited by 1 publication

References 51 publications

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

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