A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy

Shi, Huifang; Zheng, Fangying; Zheng, Yilin; Sun, Xianbin; Chen, Haijun; Gao, Yu

doi:10.1016/j.jphotobiol.2024.112886

Journal of Photochemistry and Photobiology B: Biology

2024

DOI: 10.1016/j.jphotobiol.2024.112886

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A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy

Huifang Shi,

Fangying Zheng,

Yilin Zheng

et al.

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Cited by 2 publications

References 61 publications

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Sun,

Zhang

et al. 2024

Adv Healthcare Materials

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Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species (ROS)‐mediated cancer therapies, exhibiting its potential as a sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions and hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals (•OH). Its notable advantages in cancer treatment have been demonstrated, including tumor specificity, autonomy from external triggers, and a favorable side‐effect profile. Recent advancements in nanomedicine have been devoted to enhancing CDT, promising a comprehensive optimization of CDT efficacy. This review systematically elucidates cutting‐edge achievements in chemodynamic nanotherapeutics, exploring strategies for enhanced Fenton or Fenton‐like reactions, improved tumor microenvironment modulation, and precise regulation in energy metabolism. Moreover, a detailed analysis of diverse CDT‐mediated combination therapies is provided. Finally, the review concludes with a comprehensive discussion of the prospects and intrinsic challenges to the application of chemodynamic nanotherapeutics in the domain of cancer treatment.This article is protected by copyright. All rights reserved

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Sun,

Zhang

et al. 2024

Adv Healthcare Materials

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Self-Healing Photothermal Nanotherapeutics for Enhanced Tumor Therapy through Triple Ferroptosis Amplification and Cascade Inflammation Inhibition

Zheng,

et al. 2024

ACS Appl. Mater. Interfaces

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The therapeutic effectiveness of photothermal therapy (PTT) is limited by heat tolerance and PTT-induced inflammation, which increases the risk of tumor metastasis and recurrence. Ferroptosis combined with PTT can achieve significant therapeutic effects. In this work, we designed self-healing photothermal nanotherapeutics to achieve effective PTT with triple-amplified ferroptosis and cascade inflammation inhibition after photothermal treatment. After the ferroptosis-inducing ability of mangiferin (MF) was first elucidated, the nanocomplex PFeM, coordinated by Fe 3+ and MF with polyvinylpyrrolidone (PVP) modification, was prepared by a one-pot self-assembly method. PFeM with laser irradiation could induce intensified ferroptosis by integrating the functions of MF to deactivate glutathione peroxidase 4, Fe 3+ /Fe 2+ to generate lethal reactive oxygen species via the Fenton reaction, and the photothermal effect to amplify ferroptosis. More importantly, the released MF could achieve cascade inflammation inhibition, thereby reversing the proinflammatory microenvironment caused by PTT. The in vivo antitumor and antiinflammatory effects of PFeM were further confirmed in a 4T1 tumor-bearing mouse model. This study expounding the ferroptosisinducing effects of MF and utilizing the strategy of chelating MF with iron ions can provide a new idea for developing photothermal nanoagents with clinically convertible safety ingredients and a green preparation process that improve efficacy and reduce adverse reactions during PTT.

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A carrier-free tri-component nanoreactor for multi-pronged synergistic cancer therapy

Cited by 2 publications

References 61 publications

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Self-Healing Photothermal Nanotherapeutics for Enhanced Tumor Therapy through Triple Ferroptosis Amplification and Cascade Inflammation Inhibition

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