A CARE-compliant article: Unicentric Castleman disease presenting as a retroperitoneal mass of the upper edge of the pancreas

Abstract

Rationale: Castleman disease (CD) is a rare lymphoproliferative disease with a poorly understood etiology. The occurrence of CD in the abdominal cavity is very rare, especially in the retroperitoneal peripancreatic region. Patient concerns: A 33-year-old woman was referred to our department on March 1, 2018 for a detailed physical examination due to retroperitoneal peripancreatic lymph node enlargement over 15 days. Diagnosis: Enhanced magnetic resonance imaging of the epigastrium showed the mass with abundant blood supply is located between the liver and the stomach in the upper margin of the pancreas. Postoperative pathological examination revealed CD, type of unicentric Castleman disease. Interventions: We performed an open surgery on this patient and completely removed the mass. There was no postoperative radiochemotherapy. Outcomes: The patient was followed-up for more than 12 months after the operation and showed good recovery. Lessons: CD is a rare disorder that is hard to diagnose early and complete resection of the tumor is still the most effective treatment.

Inflammatory pseudotumor of Castleman disease and IgG4-related disease masquerading as kidney malignancy

“…3 The antegrade urography of the left (A) and right (B) kidney, and contrast-enhanced abdominal CT urography of the lesions (red arrow) during plain scan phase (C), arterial phase (D), venous phase (E) and delayed phase (F) in case 2 kidney malignancy by imaging alone. Furthermore, the postoperative histopathological result of CD is generally different from the preoperative imaging diagnosis [30]. Unfortunately, core needle biopsy was not taken to confirm the preoperative pathological diagnosis, resulting in subsequent radical nephrectomy in case 1.…”

“…Due to the lack of specificity in imaging findings, it is difficult to distinguish them from kidney malignancy by imaging alone. Furthermore, the postoperative histopathological result of CD is generally different from the preoperative imaging diagnosis [ 30 ]. Unfortunately, core needle biopsy was not taken to confirm the preoperative pathological diagnosis, resulting in subsequent radical nephrectomy in case 1.…”

Inflammatory Pseudotumor of Castleman Disease and IgG4-related Disease Masquerading as Kidney Malignancy

“…Due to the lack of speci city in imaging ndings, it is di cult to distinguish them from kidney malignancy by imaging alone. Furthermore, the postoperative histopathological result of CD is generally different from the preoperative imaging diagnosis (27).…”

Autoreactive Antibodies Associated with Castleman Disease Triad

“…Interestingly, reactive lymph node involvement is frequently observed in a rare CD subvariant of TAFRO (thrombocytopenia, ascites/anasarca, myelofibrosis/fever, renal dysfunction/reticulin fibrosis, and organomegaly) [ 28 ]. A few studies have found unicentric HV-CD arising from an accessory spleen or reported Castleman tumors arising from other uncommon locations [ 29 – 33 ]. However, our case strongly favors the tumor arising from a lymph node.…”