A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

Regazzoni, Francesco; Salvador, Matteo; Africa, Pasquale Claudio; Fedele, Marco; Dedè, Luca; Quarteroni, Alfio

doi:10.1016/j.jcp.2022.111083

Cited by 63 publications

(139 citation statements)

References 91 publications

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“…To prescribe a physiological displacement to the domain boundary, we employ the ventricular electromechanics (EM) model developed in Regazzoni et al (2022); Piersanti et al (2022) coupled to the surrounding circulation described by a 0D lumped-parameter hemodynamic model. We introduce a novel procedure that combines an 2022)).…”

Section: Models and Methodsmentioning

confidence: 99%

“…To address the reciprocal influence between the hemodynamics of the heart chambers and the one of the surrounding cardiocirculatory system, we rely on the geometric multiscale modeling (Quarteroni et al (2016)). We couple the 3D CFD model of the heart with the 0D lumped parameter model closed-loop model of the circulation introduced in Regazzoni et al (2022). The interfaces conditions of the 3D-0D CFD model consists of the enforcement of the continuity of pressures and flowrates on the artificially chopped boundaries.…”

Section: Models and Methodsmentioning

confidence: 99%

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An integrated multiscale CFD model of the human heart

Zingaro¹,

Dedè²,

Quarteroni³

2022

MATHMOD 2022 Discussion Contribution Volume

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We introduce a CFD model for the numerical simulation of the heart hemodynamics in both physiological and pathological conditions, by accounting for all the physical processes that influence cardiac flows: moving domain and interaction with electromechanics, transitionalturbulent flows, cardiac valves and coupling with the external circulation. To impose a physiological displacement of the domain boundary, we employ a 3D ventricular electromechanical model coupled to a lumped-parameter (0D) closed-loop model of the circulation and the remaining cardiac chambers. To extend the ventricular motion to the endocardium of the remaining heart, we introduce a novel preprocessing procedure that combines an harmonic extension of the electromechanical displacement with the motion of the atria based on the 0D model. We thus obtain a one-way coupled electromechanics-fluid dynamics model in the ventricle(s). To better match the 3D CFD with blood circulation, we also couple the 3D CFD model to the 0D circulation model. We obtain a multiscale coupled 3D-0D fluid dynamics model that we solve via a segregated numerical scheme. We carry out numerical simulations for a healthy heart and we validate our model by showing that significant hemodynamic indicators are correctly reproduced.

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Section: Models and Methodsmentioning

confidence: 99%

Section: Models and Methodsmentioning

confidence: 99%

An integrated multiscale CFD model of the human heart

Zingaro¹,

Dedè²,

Quarteroni³

2022

MATHMOD 2022 Discussion Contribution Volume

View full text Add to dashboard Cite

show abstract

“…The muscle displacement is modeled using elastodynamics equations, as described e.g. in Regazzoni et al (2022), fed with the activation state computed by the activation model to compute the active stress contribution. We use Guccione and Neo-Hooke constitutive models for passive mechanics.…”

Section: Models and Numerical Methodsmentioning

confidence: 99%

“…Nonetheless, the core models have been studied in detail either in a standalone way or with reduced coupling to other models (see e.g. Augustin et al (2016), Gurev et al (2011), Regazzoni et al (2022, Nordsletten et al (2011), This et al (2020, Zingaro et al (2022)).…”

Section: Introductionmentioning

confidence: 99%

Coupled computational modeling of cardiac electrophysiology, mechanics and fluid dynamics

Bucelli¹,

Dedè²,

Quarteroni³

2022

MATHMOD 2022 Discussion Contribution Volume

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We propose a computational model of a human heart including three-dimensional descriptions for electrophysiology, solid mechanics and fluid dynamics of the blood, aiming at reproducing the feedback mechanisms that occur within the heart. The model is obtained combining standalone physical models used in the cardiac modeling literature, introducing coupling terms, resulting in a multi-way coupled integrated model. We numerically solve the model with a staggered scheme. Fluid dynamics and solid mechanics are coupled implicitly with a monolithic scheme. The staggered scheme allows to select different timesteps for the different core models, leveraging the multiscale and multiphysics nature of the model. Simulations results on a realistic human heart model are consistent with the behavior shown by healthy hearts.

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“…We discretize the NS-ALE-RIIS equations in space via the finite element (FE) method and in time by means of backward differentiation formulas. We use a Variational Multiscale -Large Eddy Simulation method (Forti and Dede' ( 2015)) to get a stable formulation of the NS equations discretized by means of FE method; to stabilize the advection-dominated regime and to account for turbulence modeling within the framework of LES (Zingaro et al (2021)). We discretize the system of ODEs of the 0D circulation model through a 4 th order explicit Runge-Kutta scheme.…”

Section: Models and Methodsmentioning

confidence: 99%

MATHMOD 2022 Discussion Contribution Volume

2022

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About ARGESIMARGESIM is a non-profit society generally aiming for dissemination of information on system simulation from research via development to applications of system simulation. ARGESIM is closely co-operating with EU-ROSIM, the Federation of European Simulation Societies, and with ASIM, the German Simulation Society. ARGESIM is an 'outsourced' activity from the Mathematical Modelling and Simulation Group of TU Wien, there is also close co-operation with TU Wien (organisationally and personally). ARGESIM Publisher organizes publishing activities, with ISBN root 978-3-901608-xx-y and DOI root 10.11128/xx…x.

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A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

Cited by 63 publications

References 91 publications

An integrated multiscale CFD model of the human heart

An integrated multiscale CFD model of the human heart

Coupled computational modeling of cardiac electrophysiology, mechanics and fluid dynamics

MATHMOD 2022 Discussion Contribution Volume

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