A Card Double Face: Compounds Functionality and Synergy of a Topical Treatment Proposed for Oral Health Improvement in Periodontal Disease

Totu, Eugenia Eftimie; Cristache, Corina Marilena; Buga, Roxana; Dumitru, Florina; Totu, Tiberiu

doi:10.37358/rc.19.5.7167

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Furthermore, another drawback related to the golden standard is the long-term resorption rate 17–19. Tissue engineering is becoming nowadays more and more popular: strategies such as bone scaffolds, biological membranes,20 bone morphogenetic protein 2, are now being studied for the first time, and still, a limited evidence has been reported in the literature 21…”

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confidence: 99%

“…Furthermore, another drawback related to the golden standard is the long-term resorption rate. [17][18][19] Tissue engineering is becoming nowadays more and more popular: strategies such as bone scaffolds, biological membranes, 20 bone morphogenetic protein 2, are now being studied for the first time, and still, a limited evidence has been reported in the literature. 21 We report our experience in the surgical management of these lesions with deproteinized bovine bone matrix blocks wrapped in a resorbable biological collagen membrane, compared with our technique of choice with autologous grafts.…”

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confidence: 99%

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A 3-Dimensional Evaluation of Bone Density in Alveolar Cleft Grafting Methods: Bone Substitutes Versus Autologous Bone

Bianchi

Cicciù

Ruggiero

et al. 2022

Journal of Craniofacial Surgery

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Introduction: Secondary alveolar cleft repair using autologous bone graft is currently the gold standard in treating residual alveolar clefts. Despite its effectiveness, this technique is still burdened by several withdrawals, mostly related to donor site morbidity. To decrease disadvantages for patients, numerous attempts in the literature regarding bone substitutes have been described. The aim of this study is to compare the viability of bovine-based replacement bone material with respect of autologous bone graft in alveolar cleft reconstruction, through 3-dimensional alveolar cleft segmentation and bone density evaluation from preoperative and postoperative cone-beam computed tomography. Patients and Methods: A retrospective cohort study of 10 patients who underwent surgical procedure for alveolar cleft grafting at Sant’Orsola Malpighi University Hospital of Bologna from December 2012 to December 2016 was undertaken. Five patients received autologous bone graft and 5 a bovine bone substitute graft. Preoperative and immediate postoperative orthopanoramic x-rays were recorded. Cone-beam computed tomography scans have recorded both pre and postoperatively. Volumetric evaluation on 3-dimensional cone-beam computed tomography images was performed. Results: Alveolar clefts repaired using substitute bovine bone/biological membrane scaffold had a mean fill of 69.00% of total cleft volume, while this figure was of 67.07% with autologous bone grafting. The immediate postoperative course and subsequent discharge were uneventful for both groups, with a difference in timing. The cost of substitute bovine bone was offset by cost savings associated with a reduction in operative and postoperative and hospitalization time. Conclusions: Bone substitutes showed to be a promising solution in alveolar cleft grafting.

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confidence: 99%

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confidence: 99%

A 3-Dimensional Evaluation of Bone Density in Alveolar Cleft Grafting Methods: Bone Substitutes Versus Autologous Bone

Bianchi

Cicciù

Ruggiero

et al. 2022

Journal of Craniofacial Surgery

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Bioactive Hybrid Material with Applications in Dental Medicine

Totu

Işildak²,

Petre

et al. 2019

2019 E-Health and Bioengineering Conference (EHB)

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Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

et al. 2022

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(1) Background: The standard treatment for periodontal disease, a chronic inflammatory state caused by the interaction between biofilms generated by organized oral bacteria and the local host defense response, consists of calculus and biofilm removal through mechanical debridement, associated with antimicrobial therapy that could be delivered either systemically or locally. The present study aimed to determine the effectiveness of a hyaluronic acid membrane matrix as a carrier for the controlled release of the active compounds of a formulation proposed as a topical treatment for periodontal disease, and the influence of pH on the complex system’s stability. (2) Methods: The obtained hyaluronic acid (HA) hydrogel membrane with dispersed melatonin (MEL), metronidazole (MZ), and tetracycline (T) was completely characterized through FTIR, XRD, thermal analysis, UV-Vis and fluorescence spectroscopy, fluorescence microscopy, zeta potential and dielectric analysis. The MTT viability test was applied to check the cytotoxicity of the obtained membranes, while the microbiological assessment was performed against strains of Staphylococcus spp. and Streptococcus spp. The spectrophotometric investigations allowed to follow up the release profile from the HA matrix for MEL, MZ, and T present in the topical treatment considered. We studied the behavior of the active compounds against the pH of the generated environment, and the release profile of the bioactive formulation based on the specific comportment towards pH variation. The controlled delivery of the bioactive compounds using HA as a supportive matrix was modeled applying Korsmeyer–Peppas, Higuchi, first-order kinetic models, and a newly proposed pseudo-first-order kinetic model. (3) Results: It was observed that MZ and T were released at higher active concentrations than MEL when the pH was increased from 6.75, specific for patients with periodontitis, to a pH of 7.10, characterizing the healthy patients. Additionally, it was shown that for MZ, there is a burst delivery up to 2.40 × 10−5 mol/L followed by a release decrease, while for MEL and T a short release plateau was recorded up to a concentration of 1.80 × 10−5 mol/L for MEL and 0.90 × 10−5 mol/L for T, followed by a continuous release; (4) Conclusions: The results are encouraging for the usage of the HA membrane matrix as releasing vehicle for the active components of the proposed topical treatment at a physiological pH.

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A Card Double Face: Compounds Functionality and Synergy of a Topical Treatment Proposed for Oral Health Improvement in Periodontal Disease

Cited by 3 publications

References 17 publications

A 3-Dimensional Evaluation of Bone Density in Alveolar Cleft Grafting Methods: Bone Substitutes Versus Autologous Bone

A 3-Dimensional Evaluation of Bone Density in Alveolar Cleft Grafting Methods: Bone Substitutes Versus Autologous Bone

Bioactive Hybrid Material with Applications in Dental Medicine

Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

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