A Carcinogenicity Assay of Mirex in Charles River CD Rats2

Abstract

The long-term administration of 50 and 100 ppm of Mirex in the diets of male and female Charles River CD rats was associated with a spectrum of liver lesions, from foci or areas of cellular alteration and neoplastic nodules to hepatocellular carcinoma. Statistically significant numbers of neoplastic nodules were observed in the livers of male rats receiving the high dose. Neoplastic nodules and hepatocellular carcinomas were not observed in control rats.

Mutagenicity, Carcinogenicity, and Teratogenicity of Insecticides

“…Its ability to increase the incidence of hepatomas was reported by Innes et al (1969) in mice. This long-term study was repeated in Charles River CD rats (50 and 100 ppm in the diet) by Ulland et al (1977), who confirmed their previous preliminary results. 4.…”

Oxidation of thiourea and substituted thioureas: a review

“…In the second step, the sulfur atoms in the disulfide are oxidized from −1 to +6 oxidation state, converting the disulfide to sulfate and chromium(VI) to chromium(III) (Scheme 13). 6 Ethylene thiourea (ETU), 2-imidazolidinethion, is of special interest and concern because of potential human exposure and adverse health effects and also a liver and thyroid carcinogen in mice and/or rats (63)(64)(65). Therefore, its degradation is essential for an eco-friendly environment.…”

Atsdr Evaluation of Health Effects of Chemicals

“…The adaptive effects observed are those generally produced by halogenated hydrocarbons; these include increase in liver weight or size (Gaines and Kimbrough, 1970;Mehendale et al, 1973;Abston and Yarbrough, 1976;Davison et al, 1976;Chadwick et al, 1977;Fulfs et al, 1977;Villeneuve et al, 1977;Robinson and Yarbrough, 1978a,c;Warren et al, 1978;Hewitt et al, 1979;Larson et al, 1979a;Pittz et al, 1979;Chu et al, 1980bChu et al, , 1981aMehendale, 1981b;Robacker et al, 1981;Yarbrough et al, 1981Yarbrough et al, , 1984Yarbrough et al, , 1986aYarbrough et al, ,b, 1992Ritchie and Ho, 1982;Chambers and Trevethan, 1983;Ervin and Yarbrough, 1983;Fujimori et al, 1983;Williams and Yarbrough, 1983;Curtis and Hoyt, 1984;Karl and Yarbrough, 1984;Jovanovich et al, 1987;Plaa et al, 1987;Purushotham et al, 1988;Wilson and Yarbrough, 1988;Elgin et al, 1990;Teo and Vore, 1991;Thottassery and Yarbrough, 1991 ). Other effects observed include hepatocellular hypertrophy (Gaines and Kimbrough, 1970;Davison et al, 1976;Fulfs et al, 1977;Ulland et al, 1977a;Yarbrough et al, 1981), cytopla...…”