A carbon minibeam irradiation facility concept

Mayerhofer, Michael; Bencini, Vittorio; Sammer, Matthias; Dollinger, G.

doi:10.1088/1742-6596/2420/1/012097

Cited by 1 publication

(2 citation statements)

References 18 publications

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“…In general, the sensitivity of the MBC to setup uncertainties renders MBCs an inferior choice for iMBRT generation when compared to beam focusing methods [13,35]. However, since no contemporary clinical carbon ion therapy facility has access to the required beam optics to achieve the desired minibeam widths, pre-clinical experiments need to rely on MBCs as a more practical option.…”

Section: Discussionmentioning

confidence: 99%

“…iMBRT in general can be accomplished with similar infrastructure to proton minibeam therapy, either by placing a minibeam collimator (MBC) in front of the patient [8] or by magnetically focusing the beam to achieve the desired sub-millimeter beam width [13]. While magnetically focused medical carbon ion beams would be the more elegant solution compared to collimators, such beams are not yet available.…”

Section: Introductionmentioning

confidence: 99%

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Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors

et al. 2023

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Particle minibeam therapy has demonstrated the potential for better healthy tissue sparing due to spatial fractionation of the delivered dose. Especially for heavy ions, the spatial fractionation could enhance the already favorable differential biological effectiveness at the target and the entrance region. Moreover, spatial fractionation could even be a viable option for bringing ions heavier than carbon back into patient application. To understand the effect of minibeam therapy, however, requires careful conduction of pre-clinical experiments, for which precise knowledge of the minibeam characteristics is crucial. This work introduces the use of high-spatial-resolution CMOS sensors to characterize collimator-produced carbon ion minibeams in terms of lateral fluence distribution, secondary fragments, track-averaged linear energy transfer distribution, and collimator alignment. Additional simulations were performed to further analyze the parameter space of the carbon ion minibeams in terms of beam characteristics, collimator positioning, and collimator manufacturing accuracy. Finally, a new concept for reducing the neutron dose to the patient by means of an additional neutron shield added to the collimator setup is proposed and validated in simulation. The carbon ion minibeam collimator characterized in this work is used in ongoing pre-clinical experiments on heavy ion minibeam therapy at the GSI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%