A Capillary Membrane Oxygenator

Bodell, Bruce R.; Head, James M.; Head, Louis R.; Formolo, Anthony J.; Head, Jerome R.

doi:10.1016/s0022-5223(19)33636-0

Cited by 32 publications

(6 citation statements)

References 3 publications

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“…In the same decade, the relationship between blood boundary layer distribution and gas diffusion was recognized, and considerable work went into designing new membrane geometries and active components for disturbing laminar flow. Benchmark designs include the capillary oxygenator by Bodell [46] which used hollow fiber membranes to control blood boundary layers, the flat sheet oxygenator by Bramson [47], and the deforming membrane oxygenator by Kolobow [48]. Many other designs were proposed, but into the early 1970s membrane oxygenators remained an experimental technology, with none attaining the required gas-transfer capacity and reliability needed for widespread clinical acceptance [49].…”

Section: Rise Of Membrane Oxygenatorsmentioning

confidence: 99%

Bioengineering Progress in Lung Assist Devices

2021

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Artificial lung technology is advancing at a startling rate raising hopes that it would better serve the needs of those requiring respiratory support. Whether to assist the healing of an injured lung, support patients to lung transplantation, or to entirely replace native lung function, safe and effective artificial lungs are sought. After 200 years of bioengineering progress, artificial lungs are closer than ever before to meet this demand which has risen exponentially due to the COVID-19 crisis. In this review, the critical advances in the historical development of artificial lungs are detailed. The current state of affairs regarding extracorporeal membrane oxygenation, intravascular lung assists, pump-less extracorporeal lung assists, total artificial lungs, and microfluidic oxygenators are outlined.

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Section: Rise Of Membrane Oxygenatorsmentioning

confidence: 99%

Bioengineering Progress in Lung Assist Devices

2021

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“…The development of membrane technology led to the creation of polymer membranes in the form of hol-low fibers (capillaries), the internal and external diameter of which is set by the parameters of the die hole upon their formation. Consequently, this led to the development of capillary oxygenators, the first of which had capillaries with a diameter of 100-500 μm [22]. The small diameter of the hollow fibers made it possible to increase the efficiency of gas exchange due the decrease in the size of the channels and thickness of the blood layer under saturation with oxygen near the gas-exchange surface.…”

Section: Nonporous (Diffusion) Polymermentioning

confidence: 99%

Membranes in Extracorporeal Blood Oxygenation Technology

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Журавель

Alentiev

et al. 2019

Membr. Membr. Technol.

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The development and implementation of the extracorporeal membrane oxygenation (ECMO) technique for the treatment of patients in critical conditions make it possible to effectively and safely support gas exchange processes in the blood for a long time. One of the main components of the ECMO unit is a gas permeable membrane which is a barrier separating the blood from the gas phase. Since the 1950s, the development of this technology has been aimed at improving the safety and duration of use of membranes, which led to the creation of oxygenators that provide life support for several weeks. This review is devoted to the development of the extracorporeal membrane oxygenation technology including the choice of materials, methods to improve their hemocompatibility, and approaches to the design of the membrane contactor.

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“…Advances in membrane technology in the 1960s led to the introduction of silicone rubber membranes that were much more permeable to respiratory gases, giving rise to the first commercial membrane BOs 9,10. In the 1960s the first hollow fiber BOs were also developed using silicone rubber tubing 11. Blood flow inside and outside the fibers was studied 11–16.…”

Section: Introductionmentioning

confidence: 99%

“…In the 1960s the first hollow fiber BOs were also developed using silicone rubber tubing 11. Blood flow inside and outside the fibers was studied 11–16. Although blood flow outside the fibers leads to higher rates of gas transfer,17 early commercial designs were restricted to blood flow inside the fibers due to complexities in designing BOs with blood flow outside the fibers.…”

Section: Introductionmentioning

confidence: 99%

Designing Blood Oxygenators

Wickramasinghe

Goerke

Garcia

et al. 2003

Annals of the New York Academy of Sciences

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Extracorporeal blood oxygenators are used to provide cardiopulmonary support during open heart surgery. In the study reported here, mass transfer correlations were determined for commercially available blood oxygenators. Two configurations used commercially, flow outside and across bundles of hollow fibers and flow in thin channels between parallel flat sheet membranes, were investigated. Water and glycerol/water mixtures were used as a substitute for blood. Diffusion of oxygen into and out of these solutions was studied. For flow across bundles of hollow fibers, the mass transfer correlations derived here are in agreement with analogous correlations for crossflow heat exchangers. However, for flow in thin channels, the rate of mass transfer is often less than predicted from theory. This compromised mass transfer can be explained by considering slight variations in the thickness of the blood flow channels. The mass transfer correlations developed here could be used to design better blood oxygenators.

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A Capillary Membrane Oxygenator

Cited by 32 publications

References 3 publications

Bioengineering Progress in Lung Assist Devices

Bioengineering Progress in Lung Assist Devices

Membranes in Extracorporeal Blood Oxygenation Technology

Designing Blood Oxygenators

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