2022
DOI: 10.1016/j.biopha.2021.112439
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A canthin-6-one derivative induces cell death by apoptosis/necroptosis-like with DNA damage in acute myeloid cells

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Cited by 9 publications
(5 citation statements)
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“…Herein, it is found that its derivative, 10-methoxycanthin-6-one (Mtx-C), has the highest anticancer activity in the AML Kasumi-1 cells and KG-1 cells, and the mechanism of inducing cell death was established. Mtx-C could promote the necroptotic pathway, accompanied by an increase in phosphorylation of RIPK3 Ser227 and MLKL Ser358 in Kasumi-1 cells [ 277 ].…”
Section: Targeting Other Rcd Subroutines With Indole Alkaloids In Cancermentioning
confidence: 99%
See 1 more Smart Citation
“…Herein, it is found that its derivative, 10-methoxycanthin-6-one (Mtx-C), has the highest anticancer activity in the AML Kasumi-1 cells and KG-1 cells, and the mechanism of inducing cell death was established. Mtx-C could promote the necroptotic pathway, accompanied by an increase in phosphorylation of RIPK3 Ser227 and MLKL Ser358 in Kasumi-1 cells [ 277 ].…”
Section: Targeting Other Rcd Subroutines With Indole Alkaloids In Cancermentioning
confidence: 99%
“…In addition, Mtx-C can regulate the necroptotic pathway, which is associated with phosphorylation of RIP3 Ser227 and MLKL Ser358. Meanwhile, DNA damage and activation of p38 and JNK MAPKs stress pathways are also involved in Mtx-C-induced cell death [ 277 ].…”
Section: Key Signaling Involved In Cross Talk Between Different Rcd S...mentioning
confidence: 99%
“…The phototoxicity of PYT NPs + NIR was further evaluated in 4T1 cells stained with Annexin V-uorescein isothiocyanate (Annexin V-FITC)/7-aminoactinomycin D (7-AAD) using ow cytometry [30,31]. The Q2 and Q3 represented to late apoptosis cells and the early apoptotic cells, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…The phototoxicity of PYT NPs + NIR was further evaluated in 4T1 cells stained with Annexin V-fluorescein isothiocyanate (Annexin V-FITC)/7-aminoactinomycin D (7-AAD) using flow cytometry [50][51][52]. The Q2 and Q3 represented to late apoptosis cells and the early apoptotic cells, respectively.…”
Section: Resultsmentioning
confidence: 99%