A candidate interferon-gamma activated site (GAS element) in the HLA-G promoter does not bind nuclear proteins

Chu, Wenjiang; Gao, Jianjun; Murphy, William J.; Hunt, Joan S.

doi:10.1016/s0198-8859(99)00091-9

Cited by 24 publications

(17 citation statements)

References 25 publications

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“…Indeed, the putative ISRE site (ISRE Ϫ754 ) showed binding of IRF1 using nuclear extracts from IFN␥-stimulated JEG-3 cells. However, no STAT1 binding was detected to the two putative GAS sites (GAS Ϫ1020 and GAS Ϫ985 ), which is in line with findings by others (26). The binding of IRF1 to the ISRE Ϫ754 raised the possibility that IFN␥ could induce transactivation of HLA-G.…”

Section: Discussionsupporting

confidence: 90%

HLA-G Transactivation by cAMP-response Element-binding Protein (CREB)

Gobin

Biesta

Steenwinkel

et al. 2002

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 90%

HLA-G Transactivation by cAMP-response Element-binding Protein (CREB)

Gobin

Biesta

Steenwinkel

et al. 2002

Journal of Biological Chemistry

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“…Different results acquired to date strongly support that HLA-G expression is tightly regulated by post-transcriptional events such as increased mRNA stability or protein translation and control on the secretory pathway (35,36). We favor the hypothesis that HCMV is likely to affect these post-transcriptional molecular regulatory mechanisms.…”

Section: Discussionmentioning

confidence: 60%

Modulation of HLA-G Antigens Expression by Human Cytomegalovirus: Specific Induction in Activated Macrophages Harboring Human Cytomegalovirus Infection

Onno

Pangault

Friec

et al. 2000

The Journal of Immunology

154

115

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After infection, human CMV (HCMV) establishes a latent and persistent infection in immature myeloid progenitors and peripheral blood monocytes. Completion of the HCMV life cycle is possible upon maturation of monocytes to tissue macrophages and under permissive circumstances, e.g., immunosuppression. We investigated the hypothesis that HLA-G molecules could be induced during HCMV reactivation in activated macrophages to favor virus dissemination. In this study, we provide evidence that HLA-G Ags are produced during viral reactivation in macrophages generated after allogeneic stimulation of HCMV latently infected monocytes. While HLA-G surface expression is up-regulated, classical MHC-I molecules are partially down-regulated by HCMV. In vivo, bronchoalveolar macrophages collected from patients suffering from acute HCMV pneumonitis also express HLA-G molecules. The direct correlation between HLA-G Ag induction and HCMV infection was confirmed in U-373 MG astrocytoma cells. Soluble HLA-G expression is stimulated upon HCMV infection, and this modulation depends on the cooperative action of the two immediate-early-1 pp72 and immediate-early-2 pp86 products. Because HLA-G transcription is active in macrophages and U-373 MG astrocytoma cells, it is likely that the modulation of HLA-G protein expression during HCMV replication occurs at a post-transcriptional level. Our data suggest that induction of HLA-G molecules could be an additional mechanism that helps HCMV to subvert host defenses.

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“…The upstream one, located at Ϫ746 bp from the ATG, beside a GAS element (46), is highly homologous to the consensus ISRE (Fig. 3).…”

Section: Ifn-␤ Transactivation Of the Hla-g Promoter Is Mediated Thromentioning

confidence: 99%

A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-β

Lefebvre

Berrih‐Aknin

Adrián

et al. 2001

Journal of Biological Chemistry

106

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A candidate interferon-gamma activated site (GAS element) in the HLA-G promoter does not bind nuclear proteins

Cited by 24 publications

References 25 publications

HLA-G Transactivation by cAMP-response Element-binding Protein (CREB)

HLA-G Transactivation by cAMP-response Element-binding Protein (CREB)

Modulation of HLA-G Antigens Expression by Human Cytomegalovirus: Specific Induction in Activated Macrophages Harboring Human Cytomegalovirus Infection

A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-β

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