A Candidate Gene Association Study for Economically Important Traits in Czech Dairy Goat Breeds

Brzáková, Michaela; Rychtářová, Jana; Čítek, J.; Sztankóová, Z.

doi:10.3390/ani11061796

Cited by 8 publications

(8 citation statements)

References 57 publications

(69 reference statements)

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“…It is a 56-kDa enzyme that also plays a key role in regulating the levels of plasma lipoproteins in the adipose and muscular tissues as well as in other body parts such as liver, heart, nervous system, and mammary gland (Badaoui et al, 2007). The LPL gene consists of nine exons and eight introns, for a total of 3555 nucleotides (Brzáková et al, 2021). There is very little information on the influence of the goat LPL gene on the quantity and quality of production; therefore, it is important to study the polymorphisms of this gene and their influence on production as much as possible.…”

Section: Introductionmentioning

confidence: 99%

The influence of crossbreeding and LPL genotype on the yield, composition and quality of goat milk

Laučienė

2021

Mljekarstvo

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The aim of this study was to investigate the influence of crossbreeding and the LPL genotype on goat milk yield, composition and quality indicators. This research was carried out in a herd of pure-breed Saanen, Anglo-Nubian, and crossbred Saanen and Anglo-Nubian goats (n=137) in Lithuania. Saanen x Anglo-Nubian crossbred goats and Saanen had a significantly (P<0.05) higher (34.91% and 16.03 %, respectively) milk yield compared to Anglo-Nubian goats. The highest (P<0.05) fat and protein and the lowest (P<0.05) lactose percentages and somatic cell count were found in the milk of Anglo-Nubian goats, compared to Saanen x Anglo-Nubian crossbreds and Saanen goats. The highest (P<0.05) milk yield was determined in the CC genotype of the LPL gene (on average 20.08 % higher than in the CG and GG genotypes) of goats. However, the milk yield of the CC genotype was characterised (P<0.05) by the lowest fat, protein and milk urea levels, and the highest amount of lactose compared to the milk of the GG genotype. The study showed that breed and LPL genotype affected goat milk yield and composition and appear to be the valuable biomarkers of the goat selection process.

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Section: Introductionmentioning

confidence: 99%

The influence of crossbreeding and LPL genotype on the yield, composition and quality of goat milk

Laučienė

2021

Mljekarstvo

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“…Associations of LPL with milk fat traits and dMY have also been found in other species [41][42][43][44]. So far, no associations between LPL and milk proteins have been reported for buffaloes; however, a significant association was recently found in Czech dairy goats for this trait with the SNP LPL g.185G>T [42].…”

Section: Resultsmentioning

confidence: 79%

“…Conversely, allele A showed higher values for milk yield in homozygosity, although the estimated difference from the other two genotypes only approached the level of significance (p = 0.07) [27]. Associations of LPL with milk fat traits and dMY have also been found in other species [41][42][43][44]. So far, no associations between LPL and milk proteins have been reported for buffaloes; however, a significant association was recently found in Czech dairy goats for this trait with the SNP LPL g.185G>T [42].…”

Section: Resultsmentioning

confidence: 86%

CSN1S1, CSN3 and LPL: Three Validated Gene Polymorphisms Useful for More Sustainable Dairy Production in the Mediterranean River Buffalo

Pauciullo,

Gaspa,

Zhang

et al. 2024

Animals

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The search for DNA polymorphisms useful for the genetic improvement of dairy farm animals has spanned more than 40 years, yielding relevant findings in cattle for milk traits, where the best combination of alleles for dairy processing has been found in casein genes and in DGAT1. Nowadays, similar results have not yet been reached in river buffaloes, despite the availability of advanced genomic technologies and accurate phenotype records. The aim of the present study was to investigate and validate the effect of four single nucleotide polymorphisms (SNP) in the CSN1S1, CSN3, SCD and LPL genes on seven milk traits in a larger buffalo population. These SNPs have previously been reported to be associated with, or affect, dairy traits in smaller populations often belonging to one farm. A total of 800 buffaloes were genotyped. The following traits were individually recorded, monthly, throughout each whole lactation period from 2010 to 2021: daily milk yield (dMY, kg), protein yield (dPY, kg) and fat yield (dFY, kg), fat and protein contents (dFP, % and dPP, %), somatic cell count (SCC, 103 cell/mL) and urea (mg/dL). A total of 15,742 individual milk test day records (2496 lactations) were available for 680 buffalo cows, with 3.6 ± 1.7 parities (from 1 to 13) and an average of 6.1 ± 1.2 test day records per lactation. Three out four SNPs in the CSN1S1, CSN3 and LPL genes were associated with at least one of analyzed traits. In particular, the CSN1S1 (AJ005430:c.578C>T) gave favorable associations with all yield traits (dMY, p = 0.022; dPY, p = 0.014; dFY, p = 0.029) and somatic cell score (SCS, p = 0.032). The CSN3 (HQ677596: c.536C>T) was positively associated with SCS (p = 0.005) and milk urea (p = 0.04). Favorable effects on daily milk yield (dMY, p = 0.028), fat (dFP, p = 0.027) and protein (dPP, p = 0.050) percentages were observed for the LPL. Conversely, the SCD did not show any association with milk traits. This is the first example of a confirmation study carried out in the Mediterranean river buffalo for genes of economic interest in the dairy field, and it represents a very important indication for the preselection of young bulls destined for breeding programs aimed at more sustainable dairy production.

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“…Milk production traits are affected more by environmental factors than genetics, however, focusing on major genes can improve selection effectiveness (Brzáková et al, 2021). The CSN1S1 gene significantly impacts milk composition and technological properties for cheese production (Massender et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Genetic Structure of Slovak White Shorthaired Goat breed using CSN1S1 gene

GAŠPER,

MILUCHOVÁ,

GÁBOR

2023

JCEA

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Milk is one of the basic sources of nutrition. With the increasing incidence of allergies and the spread of knowledge about a healthy lifestyle, consumers are changing their eating habits, which partly leads to the reintroduction of goat's milk into the diet. This study aimed to evaluate and describe the genotypic and allelic structure of Slovak White Shorthaired goats for the CSN1S1 gene. For genotyping, PCR, AS-PCR and PIRA-PCR methods. The He and F IS were used for the description of the diversity of the population. Alleles E and F were the most frequent 0.3710 and 0.2944 respectively followed by B (0.1492) and A (0.1169). The less abundant allele was N with an occurrence of 0.0685. The most abundant genotypes were EF (0.2339), BE (0.1693) AN and EE with an occurrence of 0.1129 both. The White Shorthaired goat breed exhibits high values of heterozygosity (0.7661), polymorphism information content (0.6921), the effective number of alleles (3.7736) and level of possible variability realization (74.1%) for the CSN1S1 gene. The inbreeding level of the population represents a negative value (-0.0355), which indicates enough heterozygotes in the population.

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A Candidate Gene Association Study for Economically Important Traits in Czech Dairy Goat Breeds

Cited by 8 publications

References 57 publications

The influence of crossbreeding and LPL genotype on the yield, composition and quality of goat milk

The influence of crossbreeding and LPL genotype on the yield, composition and quality of goat milk

CSN1S1, CSN3 and LPL: Three Validated Gene Polymorphisms Useful for More Sustainable Dairy Production in the Mediterranean River Buffalo

Analysis of the Genetic Structure of Slovak White Shorthaired Goat breed using CSN1S1 gene

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