A candidate for a new serotype of human rotavirus

Matsuno, Shigeru; Hasegawa, Ayako; Mukoyama, Atsushi; Inouye, Sakae

doi:10.1128/jvi.54.2.623-624.1985

Cited by 217 publications

(90 citation statements)

References 6 publications

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“…Group A HRVs are responsible in most cases, whereas the epidemiological role of group B and C HRVs has not yet been clearly determined [Bridger et al, 1986;Nakata et al, 1987;Burns et al, 19891. Human and animal group A RV strains possess a common group antigen, VP6 (the gene 6 product), located in the inner viral capsid, which also contains determinants responsible for subgroup specificity [Kalica et al, 1981;Greenberg et al, 1983al. To date, six distinct HRV serotypes, including the four established serotypes 1-4 [Hoshino et al, 19841, and the two new serotypes 8 [Matsuno et al, 1985;Albert et al, 1987bl and 9 [Clark et al, 19871, have been reported. The different serotypes have been identified on the basis of their reactivity with animal hyperimmune sera in neutralization assays.…”

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confidence: 99%

Nosocomial outbreak of neonatal gastroenteritis caused by a new serotype 4, subtype 4B human rotavirus

Gerna

Förster

Parea

et al. 1990

Journal of Medical Virology

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A nosocomial outbreak of rotavirus gastroenteritis involving 52 newborns occurred between June and September 1988 at the University Children's Hospital of Freiburg, Federal Republic of Germany. Stools from 27 representative patients were examined for rotavirus serotypes, using a monoclonal antibody-based enzyme-linked immunosorbent assay. The electropherotype was also examined by polyacrylamide gel electrophoresis of genomic RNA. As many as 18 patients were found to be infected by serotype 4, subtype 4B strain, and in all of them the same electropherotype was detected. Although rotavirus from the remaining nine patients could not be typed, the electropherotype in four was identical to that of the serotype 4, subtype 4B strain. Thus, most of the patients in the outbreak were infected by the same rotavirus strain. Retrospective epidemiological studies showed that the 4B strain began to circulate at the hospital in January 1988, whereas only rotavirus serotypes 1, 3, and 4A were detected in 1985-1987. The primary case of the outbreak was presumably a newborn with acute gastroenteritis, admitted to the hospital from a small maternity unit in the same urban area. During the outbreak, 12 of 44 healthy newborns in the nurseries of the Children's Hospital and other maternity hospitals were found to be asymptomatic rotavirus carriers, and in three of the newborns the same 4B strain was detected. This is the first reported outbreak caused by a serotype 4, subtype 4B strain.

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confidence: 99%

Nosocomial outbreak of neonatal gastroenteritis caused by a new serotype 4, subtype 4B human rotavirus

Gerna

Förster

Parea

et al. 1990

Journal of Medical Virology

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“…In this retrospective analysis, serotype G8 was shown to be the predominant bovine rotavirus G type in the Higley, Arizona area during the 1974-1975 season. Serotype G8 virus was first recovered from a child with gastroenteritis in Indonesia in 1984 [29,43]; the first bovine G8 strain was isolated in Scotland in 1984 also [47,62]; later it was detected in North America and other countries [18,19,41,49,52,65]; and appears to be epidemiologically important today in parts of Africa [59]. Various reports [18,24,49,62] appear to indicate that G8 is one of the less common serotypes among bovine rotaviruses, however, the G8 has been reported to be the predominant G type in cattle in some parts of the world during certain periods of time [15,17,19].…”

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confidence: 99%

A longitudinal cohort study in calves evaluated for rotavirus infections from 1 to 12 months of age by sequential serological assays

et al. 2009

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Using an immunocytochemical staining assay involving six different recombinant baculoviruses with each expressing one of the major bovine rotavirus VP7 (G6, G8 and G10) and VP4 (P6[1], P7 [5] and P8 [11]) serotypes, we analyzed IgG antibody responses to individual proteins in archival serum samples collected from 31 calves monthly from 1 month to 12 months of age during [1974][1975] in Higley, Arizona. Seroresponses to VP7 and VP4, as determined by a 4-fold or greater antibody response, were not always elicited concurrently following infection: in some calves, (i) seroresponses to VP7 were detected earlier than to VP4 or vice versa; and (ii) a subsequent 2 nd seroresponse was detected for VP7 or VP4 only. In addition, a second infection was more likely to be caused by different G and/or P types. Analyses of serum samples showed that the most frequent G-P combination was G8P6

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“…The medical importance of the non-group A rotaviruses in human diarrhoeal illness remains to be determined. To date, at least five serotypically distinct human rotaviruses have been isolated (3).…”

Section: Introductionmentioning

confidence: 99%

Festschrift Immunological aspects of interaction between rotavirus and the intestine in infancy

Uhnoo

Dharakul²,

Riepenhoff-Talty³

et al. 1988

Immunol Cell Biol

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Summary Rotaviruses are important pathogens causing severe diarrhoea in human infants and young animals. Available information on the pathogenic mechanisms of and the immune response to rotaviruses is reviewed here. Studies in our laboratory using the suckling mouse model have focused on elucidating the nature of interaction between the virus and the gut, and on the importance of T and B cell mediated immunity in protection and recovery from the disease. Our data suggest that the age dependence of mouse rotavirus (MRV) infection isrelated to the presence of virus-specific receptors on the enterocytes. The uptake of rotavirus antigens appears to be limited to the epithelium associated with Peyer's patches. The antigen is transported to local and regional lymph nodes. Recent studies have indicated that rotavirus infection also increases the uptake of other macromolecules in the intestine. Rotavirus-specific mucosal IgA response seems to be related to the location and magnitude of MRV antigen in the lymph follicles in different segments of the small intestine. Studies in mice with different typesofimmunodeficiency suggest that a specific immune response is required for complete resolution of virus infection. Several parameters of immunity to rotavirus infection have been examined and, similar to other reports, local immunity in the intestine appears to have the most important role in protection. It also has been observed that nutritional factors may be important in modifying disease. However, there are still many questions to be answered concerning the role of immunity in mediating the pathogenesis of rotavirus infection.

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A candidate for a new serotype of human rotavirus

Abstract: We investigated genetic and serological characteristics of a human rotavirus isolate from Indonesia which had a "super short" RNA electrophoretic pattern (A.

Cited by 217 publications

References 6 publications

Nosocomial outbreak of neonatal gastroenteritis caused by a new serotype 4, subtype 4B human rotavirus

Nosocomial outbreak of neonatal gastroenteritis caused by a new serotype 4, subtype 4B human rotavirus

A longitudinal cohort study in calves evaluated for rotavirus infections from 1 to 12 months of age by sequential serological assays

Festschrift Immunological aspects of interaction between rotavirus and the intestine in infancy

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