A Candidate Case for Lymphocytic Infundibulo-Neurohypophysitis Mimicking a Neurohypophysial Tumor.

Tsujii, Satoru; Takeuchi, Juji; Koh, Makoto; Mizuta, Masatoshi; Azuma, Yoshie; Oishi, Mariko; Akazawa, Yoshiharu; Kuzuya, Hideshi

doi:10.2169/internalmedicine.36.293

Cited by 15 publications

(1 citation statement)

References 13 publications

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“…Granulomatous lesions of the pituitary gland may be caused by inflammatory reaction originating from a tumor or meningitis. 2,19,29) Therefore, many causes of inflammatory hypophysitis are subsumed under lymphocytic hypophysitis 9,12,13,17,27) and granulomatous hypophysitis. 6,20) Five cases of inflammatory anterior pituitary lesions due to craniopharyngioma and prolactinoma suggested that this entity can be differentiated from lymphocytic and granulomatous hypophysitis.…”

Section: Introductionmentioning

confidence: 99%

Hypophysitis Caused by Rathke's Cleft Cyst-Case Report-

Nishikawa

Takahashi

Shimatsu

et al. 2007

Neurol. Med. Chir.(Tokyo)

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A 62-year-old woman presented with general malaise persisting for 2 months and narrowing of her visual field. T1-weighted magnetic resonance (MR) imaging showed swelling of the pituitary gland and stalk, and a homogeneous isointense intra- and suprasellar mass enhanced by gadolinium. During outpatient follow up, her condition deteriorated rapidly and she developed diabetes insipidus and panhypopituitarism. T1-weighted MR imaging demonstrated shrinkage of the lesion and disappearance of the central hypointense area indicating the cyst cavity, especially in the pituitary stalk. She underwent surgical exploration via the transsphenoidal approach under a provisional diagnosis of lymphocytic hypophysitis. Histological examination revealed ciliated columnar cells and squamous metaplasia on the inner surface of the cyst wall, with many foamy cells, infiltration by many lymphoid cells and some eosinophils, and fibrosis in the adenohypophysitis and inflammatory hypophysitis in the anterior and posterior pituitary gland. The present neuroimaging findings of cyst shrinkage associated with rapid clinical deterioration strongly support the suggestion that rupture of Rathke's cleft cyst causes inflammatory hypophysitis.

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Section: Introductionmentioning

confidence: 99%

Hypophysitis Caused by Rathke's Cleft Cyst-Case Report-

Nishikawa

Takahashi

Shimatsu

et al. 2007

Neurol. Med. Chir.(Tokyo)

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Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant

Abe

2008

Brain Tumor Pathol

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Lymphocytic infundibulo-neurohypophysitis (LINH) was first reported by Saito et al. and Imura et al. as a cause of idiopathic central diabetes insipidus. Magnetic resonance (MR) imaging with a contrast medium demonstrates thickening of the pituitary stalk, enlargement of the neurohypophysis, or both with homogeneous enhancement. Histological examination reveals a posterior pituitary that is heavily infiltrated by lymphocytes with occasional plasma cells and other inflammatory cells. In early reports of the disorder, the lesion seemed to be limited to the neurohypophysis, but the present review showed cases with a combination of hypopituitarism and diabetes insipidus. Some of them showed partial hypopituitarism. The so-called lymphocytic infundibulo-panhypophysitis (LIPH) is now regarded as a lymphocytic hypophysitis variant. LINH and LIPH are essentially self-limited. In typical cases, conservative care with steroids and hormone replacement is recommended. Surgical intervention should be avoided because the natural course of the disorder may be self-limited. Pathophysiology of the disorder is still unknown. The unique clinical manifestations of the disorder are discussed and reviewed here.

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Lymphocytic infundibulo-neurohypophysitis: a clinical overview

et al. 2015

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Lymphocytic infundibulo-neurohypophysitis is an uncommon inflammatory disorder postulated to be autoimmune in origin. Because of the location of inflammation, it selectively affects the posterior lobe of the pituitary (neurohypophysis) and pituitary stalk (infundibulum). The most common presentation is central diabetes insipidus. Although the definitive diagnosis is established histologically by a pituitary biopsy, radiological imaging can be valuable in diagnosing this condition. In this paper, we provide an overview of the pathophysiology, investigations, management, and outcomes of lymphocytic infundibulo-neurohypophysitis.

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A Candidate Case for Lymphocytic Infundibulo-Neurohypophysitis Mimicking a Neurohypophysial Tumor.

Cited by 15 publications

References 13 publications

Hypophysitis Caused by Rathke's Cleft Cyst-Case Report-

Hypophysitis Caused by Rathke's Cleft Cyst-Case Report-

Lymphocytic infundibulo-neurohypophysitis and infundibulo-panhypophysitis regarded as lymphocytic hypophysitis variant

Lymphocytic infundibulo-neurohypophysitis: a clinical overview

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