A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT

Cruickshank, Garth; Ngoga, Desire; Detta, A.; Green, S.; James, Nicholas D.; Wojnecki, C.; Doran, J.; Hardie, J.; Chester, Michelle; Graham, Nicholas E.; Ghani, Z.; Halbert, Gavin; Elliot, Mark; Ford, Steven; Braithwaite, R. A.; Sheehan, T. M. T.; Vickerman, John C.; Lockyer, N.; Steinfeldt, Heidi; Croswell, G.; Chopra, Anita; Sugar, R; Boddy, Alan V.

doi:10.1016/j.apradiso.2009.03.016

Cited by 19 publications

(10 citation statements)

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“…BPA complexed solutions, such as BPA-fructose or BPA-mannitol, are usually used for intravenous infusion because of the low solubility of BPA at physiological pH [13, 14]. If the molecular weight of BPA-fructose is applied, coefficient is calculated as 0.0259 × [BPA-fructose dose (mg/kg)] in the formula.…”

Section: Discussionmentioning

confidence: 99%

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

et al. 2017

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PurposeThe purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) PET.MethodsRat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study. PET was performed 60 min after intravenous injection of 18F-FBPA (30.5 ± 0.7 MBq). After the PET scanning, BPA-fructose (167.3 ± 18.65 mg/kg) was administered by slow intravenous injection to the same subjects. The rats were killed 60 min after the BPA injection and tissue samples were collected from the major organs and tumors. The absolute boron concentrations (unit: ppm) in the samples were measured by inductively coupled plasma optical emission spectrometry (ICP-OES). The boron concentrations in the tissues/tumors were also estimated from the 18F-FBPA PET images using the following formula: estimated absolute boron concentration (ppm) = 0.0478 × [BPA dose (mg/kg)] × SUV. The measured absolute boron concentrations (mBC) by ICP-OES and the estimated boron concentrations (eBC) from the PET images were compared.ResultsThe percent difference between the mBC and eBC calculated based on the SUVmax was −5.2 ± 21.1% for the blood, −9.4 ± 22.3% for the brain, 1.6 ± 21.3% for the liver, −14.3 ± 16.8% for the spleen, −9.5 ± 27.5% for the pancreas, and 3.4 ± 43.2% for the tumor. Relatively large underestimation was observed for the lung (−48.4 ± 16.2%), small intestine (−37.8 ± 19.3%) and large intestine (−33.9 ± 11.0%), due to the partial volume effect arising from the air or feces contained in these organs. In contrast, relatively large overestimation was observed for the kidney (34.3 ± 29.3%), due to the influence of the high uptake in urine.ConclusionsThe absolute boron concentrations in tissues/tumors can be estimated from the SUVs on 18F-FBPA PET using a practical formula. Caution must be exercised in interpreting the estimated boron concentrations in the lung, small intestine and large intestine, to prevent the adverse effects of overexposure, which could occur due to underestimation by partial volume effect using PET.Electronic supplementary materialThe online version of this article (doi:10.1007/s12149-017-1172-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

et al. 2017

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“…Only a small number of techniques allow precise microdistribution studies of boron, one of them is secondary ion mass spectrometry (SIMS) (e.g. Cruickshank et al, 2009;Chandra et al, 2014) and another one is neutron autoradiography. A quantitative neutron autoradiography (NCR) protocol based on CR-39 solid state nuclear track detector (SSNTD) has been set-up in the Pavia BNCT group (Postuma et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Inter-comparison of boron concentration measurements at INFN-University of Pavia (Italy) and CNEA (Argentina)

Portu

Postuma

Gadan

et al. 2015

Applied Radiation and Isotopes

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“…So far, a wide variety of boron delivery agents have been synthesized [25] and tested, but only two drugs (BSH and BPA) have been used in clinical trials: Since 1968, a polyhedral borane anion, which is known as sodium borocaptate or BSH (Na 2 B 12 H 11 SH), has been used in Japan [26]. To plan an improved radiation therapy, boron phenylalanine (BPA), which is a dihydroxyboryl derivative of phenylalanine, with or without mannitol was used for the treatment of patients with glioblastoma [27].…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity and Cytotoxicity of novel 10B carrier ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid

Akan¹,

Özdemir²,

Oto³

et al. 2014

Med Sci and Discov

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A cancer research UK pharmacokinetic study of BPA-mannitol in patients with high grade glioma to optimise uptake parameters for clinical trials of BNCT

Cited by 19 publications

References 4 publications

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

Inter-comparison of boron concentration measurements at INFN-University of Pavia (Italy) and CNEA (Argentina)

Genotoxicity and Cytotoxicity of novel 10B carrier ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid

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