A Canadian multicentre prospective study on the effects of an oral contraceptive containing 3 mg drospirenone and 30 μg ethinyl oestradiol on somatic and psychological symptoms related to water retention and on body weight

Abstract

An oral contraceptive containing 3 mg DRSP and 30 microg EE significantly reduced the clinical symptoms of water retention. Body weight did not change.

Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen

“…Indeed a recent extensive overview of the available clinical data has not found a causal relationship between hormonal contraceptives and body weight43. The increase of 0.35 kg reported for DRSP/EE over one year of treatment could be explained by the antimineralocorticoid action of DRSP, which results in some loss of body water in the first months of treatment38-44-45.…”

Effects of low dose oral contraceptive pill containing drospirenone/ethinylestradiol in patients with endometrioma

“…Mabrouk et al also described the possible beneficial effect of this regimen in patients with endometriosis [12]. The OCP with DRSP/EE possesses the advantages of the antimineralocorticoid activity reflected clinically in less fluid retention [13]. The beneficial effects of OCP with DRSP/EE on moderate acne [14] and premenstrual dysphoric disorder (PMDD) are well known and highly satisfactory [15].…”

A drospirenone-containing oral contraceptive improved bleeding pattern and personal satisfaction in 914 women from Jordan, Lebanon and Syria

“…Bloating and breast tenderness are, amongst weight gain and skin blemishes, parameters of the Moos Menstrual Distress Questionnaire for symptoms of water retention [11,12] Endrikat et al [13] showed that these symptoms decrease significantly in the premenstrual phase and to a lesser degree in the menstrual phase during treatment with DRSP/EE. Similar improvements were reported by other studies [14,15] Interestingly, Fruzzetti et al [15] demonstrated that total body water and intracellular water were significantly lower after treatment with DRSP/EE in women affected by premenstrual syndrome.…”