A Call to Action by the Italian Mesotherapy Society on Scientific Research

Mammucari, Massimo; Paolucci, Teresa; Russo, Domenico; Maggiori, Enrica; Marzo, Raffaele Di; Migliore, Alberto; Massafra, Umberto; Ronconi, Gianpaolo; Ferrara, Paola Emilia; Gori, Francesca; Bifarini, B; Brauneis, Stefano; Vellucci, Renato; Mediati, Rocco Domenico; Violo, B; Natoli, Silvia; Pediliggieri, Carmen; Campli, C. Di; Collina, Maria Chiara

doi:10.2147/dddt.s321215

Cited by 8 publications

(10 citation statements)

References 28 publications

(55 reference statements)

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“…Among the NSAIDs, Diclofenac has been extensively studied for treating pain and inflammation, including myofascial syndrome. It consists of a benzene acetic derivative that stops the production of prostaglandins, which are implicated in pain and inflammation, acting as an analgesic, anti-inflammatory, and antipyretic substance [31]. It is readily available in the form of either sodium or potassium salt.…”

Section: Discussionmentioning

confidence: 99%

Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain

Ranieri,

Marvulli,

D’Alesio

et al. 2024

JPM

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Background: Mesotherapy is a procedure or a process of injecting drugs into the skin. This technique can help decrease the total drug dose due to its drug-sparing effect on the systemic route and can be utilized to treat nonspecific neck pain that occurs in the lateral and posterior neck. Methods: Ten patients with bilateral cervicobrachial pain were recruited and evaluated at T0 before treatments, T1 at the end of the treatment (42 days after T0), and T2 (72 days after T0). Assessments consisted of performing the Visual Analogue Scale (VAS) to evaluate pain evolution; a range of movement (ROM) and Bilateral trapezius’ tone, elasticity, and dynamic stiffness mensuration were performed using MyotonPro®. All patients underwent mesotherapy treatment in the trapezius muscles with 1 cc of Diclofenac Sodium and 1 cc of lidocaine diluted in 3 cc of saline for a total of 6 weeks. Results: VAS value statistically decreased at T1 and T2; ROM of neck flexion statistically increased at T1 and T2, and miometric tone and stiffness value statistically improved at T1 and T2. Conclusion: mesotherapy with Diclofenac Sodium reduced pain intensity and improved functional outcomes, with no significant adverse effects in patients with myofascial pain syndrome of cervicobrachial localization.

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Section: Discussionmentioning

confidence: 99%

Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain

Ranieri,

Marvulli,

D’Alesio

et al. 2024

JPM

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“…It should be emphasized that spinal mesotherapy was recommended by the Italian Mesotherapy Society (SIM). However, this recommendation applied to the injection of only those drugs or products which were chosen based on the diagnosis and authorized indications, thus avoiding the risk of mixing multiple products without evidence of their efficacy and safety [35].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Spinal Collagen Mesotherapy in Patients with Chronic Low Back Pain in a Three-Month Follow-Up—Retrospective Study

Koszela,

Woldańska-Okońska,

Gasik

2024

JCM

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Background: Low back pain syndrome is associated with muscular and myofascial pain and is linked with muscle overstrain or a lack of regular physical activity as well as a habitual bad posture, which cause the overload of perispinal soft tissues. One of the forms of therapy of LBP is the mesotherapy of the spine, which consists of multi-point micro-injections of drugs or medicine mixtures, which include preparations of collagen type I. The aim of the study was to assess the efficacy and safety of mesotherapy with collagen type I. Methods: A retrospective analysis of the results of the treatment of patients with chronic low back pain syndrome using mesotherapy was performed. A total of 130 patients (83 women and 47 men; mean age: 51 ± 14 years) were divided into two groups: group I (n = 65), treated with collagen type I, and group II (n = 65), treated with lignocaine 1%. Mesotherapy was performed weekly over five weeks. Patients were assessed using the following scales: the VAS, Laitinen Scale, and Revised Oswestry Low Back Pain Disability Scale before the start of the treatment, after five treatments, and at the three-month follow-up visit. Results: A statistically significant improvement was observed after the use of spinal mesotherapy both with collagen type I and lignocaine, with the collagen treatment having better results at the three-month follow-up visit. No adverse effects were observed after the procedures. Conclusions: Spinal mesotherapy using collagen type I and lignocaine seems to be an effective method in the treatment of chronic LBP. Collagen mesotherapy gives better results in the long term. Mesotherapy is a safe form of therapy.

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“…The 27 patients in group B, on the other hand, underwent mesotherapy treatment with Thiocolchicoside fl 4 mg/2 mL and Mepivacaine fl 10 mg/1 mL at our outpatient clinics, once a week, for a total of 5 sessions (5 weeks), lasting about 15 min each. SIM (Italian Mesotherapy Society) standards of good practice were followed ( 28 , 29 ). Each patient was evaluated before treatment for PTs; after disinfection with Chlorhexidine 2% and sterile gauze, a centrally acting muscle relaxant, Thiocolchicoside fl 4 mg/2 mL, and a local anesthetic, Mepivacaine fl 10 mg/1 mL, diluted in 0.9% NaCl saline, for a final volume of 10 mL were inoculated mesodermally; 6 to 12 microinjections were performed with a 27G 0.4 × 4 mm needle.…”

Section: Methodsmentioning

confidence: 99%

Extracorporeal ShockWave Treatment vs. mesotherapy in the treatment of myofascial syndromes: a clinical trial

Scaturro,

Migliorino,

Lauricella

et al. 2024

Front. Med.

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Numerous scientific papers have compared different treatment options in the management of myofascial pain syndrome. This study evaluated the efficacy of Extracorporeal ShockWave Treatment (ESWT) and mesotherapy in patients with Myofascial Pain Syndrome (MPS) in terms of improvement in pain, functional capacity, and quality of life. A case–control study was conducted on 54 patients, who were randomized into 2 groups: group A, consisting of 27 patients, who were treated with 5 sessions of focal ESWT on a weekly basis; and group B, consisting of 27 patients, who underwent 5 sessions of mesotherapy with Thiocolchicoside fl 4 mg/2 mL and Mepivacaine fl 10 mg/1 mL on a weekly basis. Patients were evaluated at enrollment (T0), after 5 weeks, at the end of rehabilitation treatment (T1), and at a follow- up 30 days after the end of treatment (T2), by administering rating scales (Numeric Rating Scale (NRS) - Pressure Pain Threshold (PPT) – Short Form-36 (SF-36)). The results showed that focal ESWT and Mesoterapy are two valid and effective treatment options in reducing algic symptoms and improving short- and long-term quality of life. However, the use of ESWTs, despite being mildly painful but tolerated, has been shown to be superior to mesotherapy in terms of pain reduction and increased functional capacity.

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A Call to Action by the Italian Mesotherapy Society on Scientific Research

Cited by 8 publications

References 28 publications

Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain

Effects of Intradermal Therapy (Mesotherapy) on Bilateral Cervicobrachial Pain

Efficacy and Safety of Spinal Collagen Mesotherapy in Patients with Chronic Low Back Pain in a Three-Month Follow-Up—Retrospective Study

Extracorporeal ShockWave Treatment vs. mesotherapy in the treatment of myofascial syndromes: a clinical trial

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