A sizeable, and sometimes overwhelming, array of knowledge is available and relevant to Sustainable Water Management (SWM). This knowledge derives not only from the natural, social and engineering sciences but also from practical experiences in water management, which is defined broadly to include all forms of water use as well as the protection of water resources and reduction of risk from water-related hazards. As a publically-funded water research institute, Eawag (the Swiss Federal Institute of Aquatic Science and Technology) faces the challenges of integrating and synthesizing available knowledge, creating new knowledge through research projects and making knowledge available in an accessible form to support engineering practice, water resources management and related policy-making. This chapter examines these challenges from an organizational perspective, discussing measures taken within Eawag to meet them and identifying remaining gaps and possible ways to address them.