This paper proposes an efficient full-parallel real-time blind calibration algorithm for frequency response mismatches in two-channel time-interleaved analog-to-digital converters (TI-ADCs). To make the algorithm compatible for high-speed and real-time scenarios, the algorithm is designed with full-parallel structure, where all the filters adopted in the algorithm are realized by using fast FIR algorithm (FFA). In order to reduce the computational complexity, we present a downsampling signed-FxLMS method to estimate the mismatch parameters, which can substantially save the resource consumption. Furthermore, the proposed calibration algorithm can provide low latency due to the utilization of FFA. Finally, we demonstrate the performance and efficiency of the proposed algorithm through simulations.