A calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing

Infection-Free and Enhanced Wound Healing Potential of Alginate Gels Incorporating Silver and Tannylated Calcium Peroxide Nanoparticles

“…These findings were particularly assigned to the presence of tannylated calcium peroxide nanoparticles with oxygen-releasing ability, with a gradually released H 2 O 2 concentration of 10.8 µM after ~8.5 h. The cellular assays demonstrated the safe oxygenation occurred in HaCaT cells when incubated on CaO 2 @TA-loaded hydrogels, which lined up to previous studies regarding the beneficial role of low H 2 O 2 concentrations on epithelial cells, fibroblasts, and keratinocytes [117,118]. Also aiming for the management of hypoxic skin wounds, CaO 2 -loaded hydrogels based on different polysaccharides (which possess an intrinsic moisture retention ability and exert beneficial bioactivity with respect to tissue repair and regeneration, such as alginate, chitosan, hyaluronic acid) have been validated as safe dressing candidates for the uncomplicated and accelerated wound healing [106,132,133]. Using different amounts of CaO 2 nanoparticles, M.Y.…”

“…This study aimed to obtain biocompatible dressing formulations that could solve two critical problems at the level of chronic wounds, namely infection and hypoxia, both being strongly damaging factors for the wound healing process. Silver nanoparticles, which are recognized for their strong and extended anti-pathogenic efficiency [100][101][102][103][104][105][106], were obtained through a microfluidic method to combat the infection. Following their characterization, a single synthesized silver sample (S_(15_15)) was selected to be used in the development of dressings.…”

“…Following their characterization, a single synthesized silver sample (S_(15_15)) was selected to be used in the development of dressings. Given their impressive and favorable role in the release of oxygen at the wound level [44,[106][107][108], tannylated calcium peroxide nanoparticles (CaO 2 @TA) were synthesized and investigated in the prospect of enhanced wound healing. When CaO 2 nanoparticles are exposed to a moist environment, the oxygen generation process occurs following a decomposition reaction [109,110].…”

Electrospun organic/inorganic hybrid nanofibers for accelerating wound healing: a review

“…For example, the generation of oxygen by nanoparticles can accelerate angiogenesis. 60,61 Furthermore, inorganic nanoparticles possessing charges or specific electron-pairing active sites on their surfaces can selectively bind to cells or other substances. 62,65,66 It should be noted that some inorganic nanoparticles also shows antimicrobial activity by releasing ions or having chemical reactions.…”

“…Oxygen releasing materials (ORMs), represented by sodium percarbonate (SPC), calcium peroxide (CPO), magnesium peroxide (MPO), and hydrogen peroxide (HPO), have become a key focus in wound repair. 60,61,136 Sodium percarbonate (SPC), an oxygen-producing compound that reacts with water to form H 2 O 2 and Na 2 CO 3 , was blended with PCL in DCM and DMF, resulting in the preparation of PCL–SPC hybrid nanofibrous membranes via electrospinning. 61 In this study, the released amount of oxygen was reflected by the increase of pH value.…”