A calcareous concretion in the posterior semicircular duct of a human labyrinth

Wright, Charles G.; Rouse, Roland C.; Zajic, Gary; Schaefer, Steven David; Hubbard, David G.; Barnard, Leo A.

doi:10.1016/s0196-0709(82)80054-9

Cited by 18 publications

(16 citation statements)

References 9 publications

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“…Two of five patients (40%) with prior abnormal vestibular function had additional vestibular loss after the cessation of the treatment, whilst one out of nine patients (11.1%) with prior normal vestibular function developed vestibular toxicity after chemotherapy ( 39 ). The only report of the histological verification showed severe loss of hair cells in peripheral vestibular sensory organs, including a crystalline spherical concretion composed of calcium carbonate in the left posterior semicircular duct, which is compatible with a positive finding of benign paroxysmal positional vertigo (BPPV) ( 37 , 38 ). This could be either the underlying cause of dizziness or an incidental finding.…”

Section: Resultsmentioning

confidence: 74%

Vestibulotoxicity Associated With Platinum-Based Chemotherapy in Survivors of Cancer: A Scoping Review

et al. 2018

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Background: Cochleotoxicity following the treatment with platinum-based chemotherapy is well documented. The potential for vestibulotoxicity is still unclear. This scoping review examined the extent of current research literature, summarized research findings and identified research gaps regarding vestibular-related adverse effects associated with platinum-based chemotherapy in survivors of cancer.Methods: Inclusion criteria followed the PICO principles: Participants, adult, and pediatric cancer patients of any cancer type; Intervention, platinum-based chemotherapy (such as cisplatin, carboplatin, and oxaliplatin); Control, none or any; Outcomes, vestibular-related adverse effects. English language articles published since 1978 were retrieved. Seventy-five eligible studies were identified from a systematic literature search, and relevant data were charted, collated, and summarized.Results: Testing for vestibulotoxicity predominately featured functional evaluation of the horizontal semicircular canal using the caloric and rotational tests. The rate of abnormal vestibular function test results after chemotherapy administration varied from 0 to 50%. The results of objective testing did not always correspond to patient symptoms. There is tentative support for patients with pre-existing loss of vestibular function to be more likely to experience vestibular toxicity after dosing with cisplatin.Conclusions: A number of studies reported significant evidence of vestibular toxicities associated with platinum-based chemotherapy, especially cisplatin. This scoping review emphasizes that vestibular toxicity needs more attention and comprehensive evaluation. Specifically, studies that analyse cumulative dose of platinum-based chemotherapy, affected sites of lesion in vestibular end organs, and the correlation and temporal patterns of cochlear and vestibular toxicity are needed.

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Section: Resultsmentioning

confidence: 74%

Vestibulotoxicity Associated With Platinum-Based Chemotherapy in Survivors of Cancer: A Scoping Review

et al. 2018

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“…Many biominerals have been assumed from their morphology to be spherulitic, including corals 70 , vertebrate otoconia 71 , crustacean statoliths 72 , fish otoliths 73,74 , and avian eggshells 75,76 . Some corals show a radial distribution of crystal orientations in transmission PICmapping 77 , others show random orientations in polarized light microscopy 78 .…”

Section: Discussionmentioning

confidence: 99%

Narrowly Distributed Crystal Orientation in Biomineral Vaterite

et al. 2015

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Biominerals formed by animals provide skeletal support, and many other functions. They were previously shown to grow by aggregation of amorphous nanoparticles, but never to grow ion-by-ion from solution, which is a common growth mechanism for abiotic crystals. We analyze vaterite (CaCO3) multi-crystalline spicules from the solitary tunicate Herdmania momus, with Polarization-dependent Imaging Contrast (PIC)-mapping, scanning and aberration-corrected transmission electron microscopies. The first fully-quantitative PIC-mapping data, presented here, measured 0°-30° angle spreads between immediately adjacent crystals. Such narrowly distributed crystal orientations demonstrate that crystallinity does not propagate from one crystal to another (0° angle spreads), nor that new crystals with random orientation (90°) nucleate. There are no organic layers at the interface between crystals, hence a new, unknown growth mechanism must be invoked, with crystal nucleation constrained within 30°. Two observations are consistent with crystal growth from solution: vaterite microcrystals express crystal faces, and are smooth at the nanoscale after cryo-fracture. The observation of 30° angle spreads, lack of interfacial organic layers, and smooth fracture figures broadens the range of known biomineralization mechanisms and may inspire novel synthetic crystal growth strategies. Spherulitic growth from solution is one possible mechanism consistent with all these observations.

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“…Also, freely moving otoconia should be dissolved after a time [34]. In some cases, however, a persistent otolithic debris can be observed for a longer time [33]. As a result of age-related degeneration, otoconia may escape the macula, and subsequently dissolve [3], except possibly, when they are confined to a small space with pathologically high calcium concentration.…”

Section: Posterior-horizontal Canal Switchmentioning

confidence: 99%

Typical and atypical benign paroxysmal positional vertigo: Literature review and new theoretical considerations

Büki

Mandalà

Nuti

2014

VES

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Atypical variants of benign paroxysmal positional vertigo (BPPV) are often encountered and frequently confusing. The authors present a hypothetical framework that accounts for all classical patterns of BPPV and several unusual variants such as BPPV without nystagmus, BPPV with downbeat nystagmus and BPPV with paradoxically direction-changing nystagmus. The authors introduce new concepts, such as "ipsicanal switch" and "horizontal short arm canalolithiasis" and suggest that their use may improve diagnosis and treatment in everyday clinical practice. The possible consequences of saccular otoconia detachment are reviewed according to the literature.

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A calcareous concretion in the posterior semicircular duct of a human labyrinth

Cited by 18 publications

References 9 publications

Vestibulotoxicity Associated With Platinum-Based Chemotherapy in Survivors of Cancer: A Scoping Review

Vestibulotoxicity Associated With Platinum-Based Chemotherapy in Survivors of Cancer: A Scoping Review

Narrowly Distributed Crystal Orientation in Biomineral Vaterite

Typical and atypical benign paroxysmal positional vertigo: Literature review and new theoretical considerations

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