A c-MWCNTs/AuNPs-based electrochemical cytosensor to evaluate the anticancer activity of pinoresinol from Cinnamomum camphora against HeLa cells

Zhou, Haixu; Huang, Rengui; Su, Tongchao; Li, Bo; Zhou, Hua‐Cheng; Ren, Jiali

doi:10.1016/j.bioelechem.2022.108133

Cited by 10 publications

(4 citation statements)

References 39 publications

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“…HeLa cells were immobilized on a GCE surface modified with multi-walled carbon nanotubes and gold nanoparticles, and the performance of the biosensor was evaluated by electrochemical impedance spectroscopy with different pinoresinol concentrations. The limit of detection value for the biosensor, which showed a linear correlation with the pinoresinol concentration range of 10 2 to 10 6 cells mL −1 , was reported as 10 2 cells mL −1 [ 114 ]. Another cell-based label-free electrochemical biosensor was developed to investigate the interactions of cancer cells (HepG2 cells and A549 cells) with molecules and to screen anticancer drugs.…”

Section: Biorecognition Elements For Label-free Electrochemical Cance...mentioning

confidence: 99%

Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

Şanko

Kuralay

2023

Biosensors

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With its fatal effects, cancer is still one of the most important diseases of today’s world. The underlying fact behind this scenario is most probably due to its late diagnosis. That is why the necessity for the detection of different cancer types is obvious. Cancer studies including cancer diagnosis and therapy have been one of the most laborious tasks. Since its early detection significantly affects the following therapy steps, cancer diagnosis is very important. Despite researchers’ best efforts, the accurate and rapid diagnosis of cancer is still challenging and difficult to investigate. It is known that electrochemical techniques have been successfully adapted into the cancer diagnosis field. Electrochemical sensor platforms that are brought together with the excellent selectivity of biosensing elements, such as nucleic acids, aptamers or antibodies, have put forth very successful outputs. One of the remarkable achievements of these biomolecule-attached sensors is their lack of need for additional labeling steps, which bring extra burdens such as interference effects or demanding modification protocols. In this review, we aim to outline label-free cancer diagnosis platforms that use electrochemical methods to acquire signals. The classification of the sensing platforms is generally presented according to their recognition element, and the most recent achievements by using these attractive sensing substrates are described in detail. In addition, the current challenges are discussed.

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Section: Biorecognition Elements For Label-free Electrochemical Cance...mentioning

confidence: 99%

Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

Şanko

Kuralay

2023

Biosensors

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“…This cytosensor detected cancer cells from 10 2 to 10 6 cells/mL and LOD was 10 2 cells/mL. The cell capture capacity of this sensor was active only if the cells concentration was in the range of 10 4 cells/mL [74]. The majority of electro-chemical cytosensors had been built using conducting nanomaterials, bio-recognition components, and at the interface of the solid-liquid electrode, CTCs (antigens) can be recognized.…”

Section: Aptasensors and Cytosensorsmentioning

confidence: 99%

Advanced electrocatalytic materials based biosensors for cancer cell detection – A review

et al. 2023

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Herein, we have highlighted the latest developments on biosensors for cancer cell detection. Electrochemical (EC) biosensors offer several advantages such as high sensitivity, selectivity, rapid analysis, portability, low‐cost, etc. Generally, biosensors could be classified into other basic categories such as immunosensors, aptasensors, cytosensors, electrochemiluminescence (ECL), and photo‐electrochemical (PEC) sensors. The significance of the EC biosensors is that they could detect several biomolecules in human body including cholesterol, glucose, lactate, uric acid, DNA, blood ketones, hemoglobin, and others. Recently, various EC biosensors have been developed by using electrocatalytic materials such as silver sulfide (Ag2S), black phosphene (BPene), hexagonal carbon nitrogen tube (HCNT), carbon dots (CDs)/cobalt oxy‐hydroxide (CoOOH), cuprous oxide (Cu2O), polymer dots (PDs), manganese oxide (MnO2), graphene derivatives, and gold nanoparticles (Au‐NPs). In some cases, these newly developed biosensors could be able to detect cancer cells with a limit of detection (LOD) of 1 cell/mL. In addition, many remaining challenges have to be addressed and validated by testing more real samples and confirm that these EC biosensors are more accurate and reliable to measure cancer cells in the blood and salivary samples.

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“…With rapid screening and label-free detection, anticancer efficacy can be efficiently tested. Specifically, several studies have described the discovery and precise analyses of anticancer medication efficacy testing in 2D and 3D culture systems involving electrochemical methods [ 58 , 59 , 60 ]. Stem cell applications keep pace with the rapid advancement of medical technologies by using the genetic information of individuals to generate the same tissues used by the in vivo system and derived from patients.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Electrochemical Biosensors for Monitoring Animal Cell Function and Viability

Koo

Kim

et al. 2022

Biosensors

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Redox reactions in live cells are generated by involving various redox biomolecules for maintaining cell viability and functions. These qualities have been exploited in the development of clinical monitoring, diagnostic approaches, and numerous types of biosensors. Particularly, electrochemical biosensor-based live-cell detection technologies, such as electric cell–substrate impedance (ECIS), field-effect transistors (FETs), and potentiometric-based biosensors, are used for the electrochemical-based sensing of extracellular changes, genetic alterations, and redox reactions. In addition to the electrochemical biosensors for live-cell detection, cancer and stem cells may be immobilized on an electrode surface and evaluated electrochemically. Various nanomaterials and cell-friendly ligands are used to enhance the sensitivity of electrochemical biosensors. Here, we discuss recent advances in the use of electrochemical sensors for determining cell viability and function, which are essential for the practical application of these sensors as tools for pharmaceutical analysis and toxicity testing. We believe that this review will motivate researchers to enhance their efforts devoted to accelerating the development of electrochemical biosensors for future applications in the pharmaceutical industry and stem cell therapeutics.

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A c-MWCNTs/AuNPs-based electrochemical cytosensor to evaluate the anticancer activity of pinoresinol from Cinnamomum camphora against HeLa cells

Cited by 10 publications

References 39 publications

Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges

Advanced electrocatalytic materials based biosensors for cancer cell detection – A review

Recent Advances in Electrochemical Biosensors for Monitoring Animal Cell Function and Viability

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