A bundled microwire array for long-term chronic single-unit recording in deep brain regions of behaving rats

Tseng, Wan-Ting; Yen, Chen‐Tung; Tsai, Meng‐Li

doi:10.1016/j.jneumeth.2011.08.028

Cited by 46 publications

(30 citation statements)

References 31 publications

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“…One of the main constraints on the duration that any electrode can yield high quality single-unit data is gliosis, the process of successive encapsulation of foreign materials by glial cells that insulate the electrode from surrounding neurons (Turner et al, 1999; Polikov et al, 2005). Even though stable recording conditions can be maintained over months in optimal conditions (Freire et al, 2011; Tseng et al, 2011), the process of glial encapsulation begins as early as one day post-implant (Fujita et al, 1998) and can lead to a progressive deterioration in the experimenter's ability to identify and discriminate individual neurons (Williams et al, 1999; Vetter et al, 2004; Dickey et al, 2009; Muthuswamy et al, 2011). Similarly, small movements of electrodes relative to the surrounding tissue can damage the neuropil and lead to a decline in unit yield over time.…”

Section: Introductionmentioning

confidence: 99%

The flexDrive: an ultra-light implant for optical control and highly parallel chronic recording of neuronal ensembles in freely moving mice

Voigts¹,

Siegle²,

Pritchett³

et al. 2013

Front. Syst. Neurosci.

151

200

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Electrophysiological recordings from ensembles of neurons in behaving mice are a central tool in the study of neural circuits. Despite the widespread use of chronic electrophysiology, the precise positioning of recording electrodes required for high-quality recordings remains a challenge, especially in behaving mice. The complexity of available drive mechanisms, combined with restrictions on implant weight tolerated by mice, limits current methods to recordings from no more than 4–8 electrodes in a single target area. We developed a highly miniaturized yet simple drive design that can be used to independently position 16 electrodes with up to 64 channels in a package that weighs ~2 g. This advance over current designs is achieved by a novel spring-based drive mechanism that reduces implant weight and complexity. The device is easy to build and accommodates arbitrary spatial arrangements of electrodes. Multiple optical fibers can be integrated into the recording array and independently manipulated in depth. Thus, our novel design enables precise optogenetic control and highly parallel chronic recordings of identified single neurons throughout neural circuits in mice.

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Section: Introductionmentioning

confidence: 99%

The flexDrive: an ultra-light implant for optical control and highly parallel chronic recording of neuronal ensembles in freely moving mice

Voigts¹,

Siegle²,

Pritchett³

et al. 2013

Front. Syst. Neurosci.

151

200

View full text Add to dashboard Cite

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“…In addition, being able to record the same neuron on different sites on the probe may help sorting spikes in multi-unit recordings, as is commonly done with tetrode recording (Tseng et al, 2011). …”

Section: Discussionmentioning

confidence: 99%

The sinusoidal probe: a new approach to improve electrode longevity

Sohal¹,

Jackson²,

Jackson³

et al. 2014

Front. Neuroeng.

109

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Micromotion between the brain and implanted electrodes is a major contributor to the failure of invasive brain–machine interfaces. Movements of the electrode tip cause recording instabilities while spike amplitudes decline over the weeks/months post-implantation due to glial cell activation caused by sustained mechanical trauma. We have designed a sinusoidal probe in order to reduce movement of the recording tip relative to the surrounding neural tissue. The probe was microfabricated from flexible materials and incorporated a sinusoidal shaft to minimize tethering forces and a 3D spheroid tip to anchor the recording site within the brain. Compared to standard microwire electrodes, the signal-to-noise ratio and local field potential power of sinusoidal probe recordings from rabbits was more stable across recording periods up to 678 days. Histological quantification of microglia and astrocytes showed reduced neuronal tissue damage especially for the tip region between 6 and 24 months post-implantation. We suggest that the micromotion-reducing measures incorporated into our design, at least partially, decreased the magnitude of gliosis, resulting in enhanced longevity of recording.

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“…These methods continue to be used by some groups, such as at Duke University [34] for many applications, but most commonly bundles of wires are used for deep brain recordings (as seen in Figure 2) [35,37]. In these systems, individual microwire electrodes are placed into the brain and then connected externally through some sort of channel connection mechanism or bundled together and encapsulated by plastic or other material before being placed in the brain (as seen in Figure 2).…”

Section: Wire Electrodes As Bundles or Arraysmentioning

confidence: 99%

Implanted intracortical electrodes as chronic neural interfaces to the central nervous system

Henderson

2015

Preprint

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Recent developments in neural interfaces show that it is possible to have fine control of a robotic prosthetic by interfacing with the motor cortex of the human brain. Development of long term systems for this purpose is a challenging task with many different possibilities. Intracortical implants have shown the most promise in providing enough signal selectivity and throughput for complex control systems with many degrees of freedom. Intracortical systems generally fall into two categories: MEMS devices and bundle of wire systems. While both show promise, MEMS systems have been greatly popularized due to their reproducibility. In particular, the Michigan probe and Utah microarray are often used as a base for construction of more complex intracortical systems. However, these systems still carry many downsides. Their long-term viability is questionable, with mixed results. The effects of damage from implantation are still inconclusive and immune responses remain a problem for long-term use. While there is some promising research in the use of bioactive molecules and biocompatible materials to prevent immune responses, more controlled study is needed before intracortical systems become widespread.

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A bundled microwire array for long-term chronic single-unit recording in deep brain regions of behaving rats

Cited by 46 publications

References 31 publications

The flexDrive: an ultra-light implant for optical control and highly parallel chronic recording of neuronal ensembles in freely moving mice

The flexDrive: an ultra-light implant for optical control and highly parallel chronic recording of neuronal ensembles in freely moving mice

The sinusoidal probe: a new approach to improve electrode longevity

Implanted intracortical electrodes as chronic neural interfaces to the central nervous system

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