A budding case of infectious endocarditis: Candida lusitaniae

Rahmati, Elham; Correa, Adrian; She, Rosemary C.

doi:10.1016/j.idcr.2019.e00679

Cited by 7 publications

(9 citation statements)

References 5 publications

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“…The detection of yeast in low frequency from faeces of Canada geese as well as other avian species has been reported (Buck, 1990; Glushakova et al., 2020). Yeasts, such as Candida spp., are commensal organisms but can cause opportunistic infections and pose potential risks to immune‐compromised humans (Blinkhorn et al., 1989; Rahmati et al., 2020; Wawrysiuk et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

Survey of zoonotic parasites and bacteria in faeces of Canada geese (Branta canadensis) in North‐Central Oklahoma

Nagamori

Litherland

Koons

et al. 2022

Veterinary Medicine & Sci

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Background As a population of non‐migratory Canada geese (Branta canadensis) has been growing in residential and recreational areas, public concerns on potential acquisition of zoonotic pathogens from Canada geese and their faecal deposits have been increasing. Objectives The main study objective was to evaluate the prevalence of zoonotic microorganisms, Campylobacter spp., Cryptosporidium spp., Giardia spp. and Salmonella spp. and antimicrobial resistant Escherichia coli in faeces of Canada geese residing in North‐Central Oklahoma, United States. Methods A total of 204 faecal samples were collected from 11 locations in North‐Central Oklahoma, where public recreational areas such as lakes and ponds were located, and Canada geese were commonly inhabited. Faecal samples were examined by a centrifugal flotation to evaluate the prevalence of Cryptosporidium spp. and Giardia spp. infections. A total of 180 faecal samples were grouped into 36 pooled samples and cultured using standard culture methods to detect the prevalence of Campylobacter spp. and Salmonella spp. infections. The antimicrobial resistance profile was determined on 32 E. coli isolates recovered from the 36 sample pools, using the Kirby Bauer Disk Diffusion method. Results The targeted zoonotic pathogens were not identified by the faecal examinations performed. Of the 32 E. coli isolates, 17 isolates (53.1%) demonstrated resistance to ≥1 antimicrobial agent. Conclusions Targeted zoonotic pathogens were not detected among the examined resident Canada geese in North‐Central Oklahoma. The findings of multiple‐antimicrobial resistant E. coli infections are potentially a public health concern although the prevalence was low in this study. Further, larger scale surveys are recommended.

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Section: Discussionmentioning

confidence: 99%

Survey of zoonotic parasites and bacteria in faeces of Canada geese (Branta canadensis) in North‐Central Oklahoma

Nagamori

Litherland

Koons

et al. 2022

Veterinary Medicine & Sci

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“…Another unique attribute of C. lusitaniae is that many isolates have demonstrated resistance to amphotericin B [4,7,8]. C. lusitaniae develops antifungal resistance rapidly.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Candida lusitaniae: Nosocomial Acquisition Secondary to an Indwelling Urinary Catheter

Raja¹,

Park

2021

Case Reports in Infectious Diseases

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Candida lusitaniae is a rare opportunistic pathogen, and its most common risk factors include immunocompromised patients often with an underlying malignancy. It commonly displays resistance to amphotericin B, and historically, echinocandins have been considered first-line treatment. We present a 77-year-old male with a history of diabetes mellitus. He was treated for cellulitis and discharged to a skilled nursing facility with an indwelling urinary catheter. Despite recommendations from the medicine team to remove the catheter, the patient refused even after discussing the risks and benefits. He returned to the hospital 3 weeks later with symptoms of dysarthria, right-sided facial droop, and right-sided weakness. Ultimately, he was determined to have fungemia and native valve endocarditis due to Candida lusitaniae stemming from his indwelling urinary catheter. He was treated with micafungin, but repeated blood cultures continued to grow C. lusitaniae, and he eventually expired following withdrawal of care. We present this case report to illustrate a rare occurence of Candida lusitaniae in a patient without typical risk factors. C. lusitaniae fungemia is an extremely uncommon disease in patients without underlying malignancy. Despite this lack of apparent, classic risk factors, our patient developed endocarditis of his native valve due to C. lusitaniae fungemia from an indwelling urinary catheter. The ability of this organism to form biofilms, and its rapid mutation rate, makes treating C. lusitaniae very difficult. The treatment of choice for C. lusitaniae endocarditis is surgical intervention due to biofilm formation on the cardiac valves. Medical treatment recommendations are currently fluconazole, which is in contrast to the historical use of echinocandins. Infection due to Candida lusitaniae, though rare, should be remembered by clinicians. This particular fungal agent is especially difficult to treat due to its multiple virulence factors. Additionally, the use of indwelling urinary catheters should only occur when proper indications are present and should be promptly discontinued when their placement is no longer necessary.

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“…Due to the possibility that some C. lusitaniae species will not respond to chemotherapy, common candidiasis caused by this strain can have serious consequences [12]. C. lusitaniae infections respond poorly to amphotericin B despite low MIC values in in-vitro tests [16]. There are no CLSI/EUCAST antifungal susceptibility breakpoints for C. lusitaniae.…”

Section: Discussionmentioning

confidence: 99%

The investigation of antifungal susceptibilities of Kluyveromyces marxianus and Clavispora lusitaniae strains isolated from various clinical specimens

Atalay¹,

Koç²,

Çakır³

et al. 2021

Journal of Surgery and Medicine

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A budding case of infectious endocarditis: Candida lusitaniae

Abstract: This is a case of recurrent Candida lusitaniae prosthetic valve endocarditis with budding yeast and pseudohyphae on the histopathology. This case illustrates the importance of keeping vigilant in recognizing some of the emerging drug resistant Candida species in our practice.

Cited by 7 publications

References 5 publications

Survey of zoonotic parasites and bacteria in faeces of Canada geese (Branta canadensis) in North‐Central Oklahoma

Survey of zoonotic parasites and bacteria in faeces of Canada geese (Branta canadensis) in North‐Central Oklahoma

Disseminated Candida lusitaniae: Nosocomial Acquisition Secondary to an Indwelling Urinary Catheter

The investigation of antifungal susceptibilities of Kluyveromyces marxianus and Clavispora lusitaniae strains isolated from various clinical specimens

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