A Bright Future? A Perspective on Class C GPCR Based Genetically Encoded Biosensors
Margulan Otanuly,
Martin Kubitschke,
Olivia Andrea Masseck
Abstract:One of the major challenges in molecular neuroscience today is to accurately monitor neurotransmitters, neuromodulators, peptides, and various other biomolecules in the brain with high temporal and spatial resolution. Only a comprehensive understanding of neuromodulator dynamics, their release probability, and spatial distribution will unravel their ultimate role in cognition and behavior. This Perspective offers an overview of potential design strategies for class C GPCR-based biosensors. It briefly highlight… Show more
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