A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

Ruiz‐Manriquez, Luis M.; Pacheco, S; Medina‐Gomez, Daniel; Urióstegui-Pena, Andrea G.; Estrada-Meza, Carolina; Bandyopadhyay, Anindya; Pathak, Surajit; Banerjee, Antara; Chakraborty, Samik; Srivastava, Aashish; Paul, Sujay

doi:10.3390/genes13020191

Cited by 8 publications

(9 citation statements)

References 81 publications

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“…Furthermore, miR-21, miR-193, and miR-214 are known to regulate cyst growth by modulating cyst epithelial apoptosis, proliferation, and interstitial inflammation [ 80 ] ( Figure 2 ).…”

Section: New Biomarkers In Adpkdmentioning

confidence: 99%

Urinary Biomarkers in Monitoring the Progression and Treatment of Autosomal Dominant Polycystic Kidney Disease—The Promised Land?

Pana,

Stanigut,

Cimpineanu

et al. 2023

Medicina

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Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease, and it leads to end-stage renal disease (ESRD). The clinical manifestations of ADPKD are variable, with extreme differences observable in its progression, even among members of the same family with the same genetic mutation. In an age of new therapeutic options, it is important to identify patients with rapidly progressive evolution and the risk factors involved in the disease’s poor prognosis. As the pathophysiological mechanisms of the formation and growth of renal cysts have been clarified, new treatment options have been proposed to slow the progression to end-stage renal disease. Furthermore, in addition to the conventional factors (PKD1 mutation, hypertension, proteinuria, total kidney volume), increasing numbers of studies have recently identified new serum and urinary biomarkers of the disease’s progression, which are cheaper and more easily to dosing from the early stages of the disease. The present review discusses the utility of new biomarkers in the monitoring of the progress of ADPKD and their roles in new therapeutic approaches.

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“…Furthermore, miR-21, miR-193, and miR-214 are known to regulate cyst growth by modulating cyst epithelial apoptosis, proliferation, and interstitial inflammation [ 80 ] ( Figure 2 ).…”

Section: New Biomarkers In Adpkdmentioning

confidence: 99%

Urinary Biomarkers in Monitoring the Progression and Treatment of Autosomal Dominant Polycystic Kidney Disease—The Promised Land?

Pana,

Stanigut,

Cimpineanu

et al. 2023

Medicina

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“…Dysfunctional granulosa cells (GCs), characterized by a poor apoptosis and increased proliferation, have proved to be typical of PCOS and are usually associated with impaired ovulation and folliculogenesis [ 11 ]. Elevated levels of circulating insulin could be responsible for GC abnormalities: specifically, it is able to favor the overexpression of mir-93 and the downregulation of mir-145, which in turn enhance cell growth and inhibit apoptosis [ 12 , 13 ].…”

Section: Mechanisms Involved In Pcos Pathogenesismentioning

confidence: 99%

“…The pharmacological modulation of miR-145 can thus represent a therapeutic strategy to resolve GCs dysfunction in PCOS [ 12 ]. Furthermore, human GCs have been found to present significant lower levels of miR-126-5p and miR-29a-5p, along with the overexpression of its target, the klotho protein, which has been suggested to regulate GC survival/apoptosis by modulating the insulin/IGF-1, Wnt1 and Akt signaling pathways [ 11 , 89 ].…”

Section: Mechanisms Involved In Pcos Pathogenesismentioning

confidence: 99%

Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome

et al. 2022

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Polycystic ovary syndrome (PCOS) is an endocrine systemic disorder mainly characterized by a hormonal and metabolic disbalance that leads to oligo/anovulation, hyperandrogenism and the formation of ovarian cysts. Despite the progress that has been reached in its diagnosis and management, little is known about the molecular mechanisms and signaling pathways underlying the pathogenic mechanisms. In this sense, recent research has suggested that the influence of multiple factors, including age, environment, lifestyle and the disease state environment can change the clinical presentation of PCOS via epigenetic modifications. Variants in the genes encoding for proteins involved in steroidogenesis and glucose homeostasis play a crucial role in the development of the disease. Other genes involved in inflammation and cell proliferation seem to undergo an epigenetic control. Moreover, lifestyle factors influence the PCOS course and prognosis, including diet and physical activity, which are fundamental in reducing oxidative stress, inflammation and in improving metabolic and hormonal parameters. In the present review, literature evidence on molecular and epigenetic mechanisms related to PCOS etiology will be discussed, with a particular attention on the positive influence of diet and physical activity as nonpharmacological ways of intervention in the management of the disease.

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“…It has also been stated that a single transcript might be targeted by multiple miRNAs, while a sole miRNA can regulate up to 200 different mRNAs ( Ruiz-Manriquez et al, 2022c ; Iacomino, 2023 ). The investigation of how miRNA-mediated regulation is influenced by factors such as miRNA abundance/localization, cell type, and cell state is currently being extensively studied ( Vishnoi and Rani, 2023 ); however, it has been hypothesized that an aberrant expression of these molecules influences critical biological processes leading to various pathological outcomes associated with diseases ( Diener et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

The regulatory role of microRNAs in common eye diseases: A brief review

et al. 2023

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MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management.

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A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers

Cited by 8 publications

References 81 publications

Urinary Biomarkers in Monitoring the Progression and Treatment of Autosomal Dominant Polycystic Kidney Disease—The Promised Land?

Urinary Biomarkers in Monitoring the Progression and Treatment of Autosomal Dominant Polycystic Kidney Disease—The Promised Land?

Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome

The regulatory role of microRNAs in common eye diseases: A brief review

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