A brief review on the rising incidence of chronic kidney diseases and non-alcoholic fatty liver disease

Nagy, Judit; Kovács, Tibor

doi:10.1556/2060.106.2019.35

Cited by 12 publications

(6 citation statements)

References 37 publications

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“…This may be explained by an increasing use of CIED in younger and sicker patients [2]; alternatively, this may have resulted from increasing operator and center experience over time positively influencing the procedure's risk-benefit ratio thereby influencing the decision to perform TLE in younger and sicker patients. Additionally, the incidence of cardiovascular risk factors including diabetes mellitus and chronic kidney disease is increasing in Switzerland in the general population, which may also explain these findings [8][9][10][11][12]. Since three of the four cardiovascular risk factors in our study demonstrated increasing trends, the percentage of TLE patients without any cardiovascular risk factors declined overall during the observed time period.…”

Section: Cardiovascular Risk At the Time Of Tlementioning

confidence: 58%

Evolution of Procedure Indication and Cardiovascular Risk in Transvenous Lead Extraction

Höfer¹,

Bebié²,

Kuster³

et al. 2022

JCM

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Background: The use of cardiac implantable electronic devices (CIEDs) to treat tachy- and bradyarrhythmia has significantly increased over the past decades. Consequently, transvenous lead extractions (TLE) have been performed more frequently, particularly in the treatment of device infection or malfunction. We aimed to evaluate the development of procedure indications and cardiovascular risk factors of patients undergoing TLE over time. Materials and methods: 277 TLE cases from 2013 to 2020 performed at the University Hospital Zurich were included in this retrospective analysis. Patient charts and follow-up letters were screened for procedure indication and cardiovascular risk factors to evaluate trends over time. Results: 502 leads were extracted in 273 patients. The main indications for TLE remained lead dysfunction (48.7%) and infection (31.4%) throughout the investigated period; however, infections were less and device upgrade more frequently encountered indications for TLE over time. Mean patient age at the time of TLE (64.0 ± 0.9 in the entire sample) decreased over time, while the incidence of chronic kidney disease (33.6%), heart failure (48.6%), or diabetes mellitus (22%) demonstrated an increasing trend. Conclusions: The main indications for TLE remain device malfunction and infection, while device upgrade was increasingly encountered as an indication for TLE in recent years. Over time, patients undergoing TLE were increasingly younger and more often presented with cardiovascular risk factors.

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Section: Cardiovascular Risk At the Time Of Tlementioning

confidence: 58%

Evolution of Procedure Indication and Cardiovascular Risk in Transvenous Lead Extraction

Höfer¹,

Bebié²,

Kuster³

et al. 2022

JCM

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“… 40 Third, other novel mechanisms, including altered level of hepatokines and perturbation of the gut microbiota (dysbiosis) in NAFLD may also play a role in the development of CKD. 11 , 41 , 42 Considering the high prevalence of NAFLD worldwide and the significant association for CKD, effective intervention in populations with NAFLD could have important impacts on the global health burden of CKD. Nowadays, lifestyle intervention is the cornerstone of treatment for NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease

Cai

Sun

Liu

et al. 2021

Therapeutic Advances in Chronic Disease

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Background and Aims: Whether non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident chronic kidney disease (CKD) independent of established cardio-renal risk factors remains controversial. We aimed to provide a quantitative estimate of the association and strength between NAFLD and risk of CKD after adjustment for multiple cardio-renal risk factors. Methods: We searched electronic databases (PubMed, Embase, and Google Scholar) for studies published from database inception until 30 November 2020. Analysis included cohort studies that reported multivariable-adjusted risk ratios [including odds ratios, relative risks (RRs), or hazard ratios] and 95% confidence intervals (CIs) for CKD of NAFLD compared with individuals without NAFLD. Results: A total of 11 cohort studies were included comprising 1,198,242 participants (46.3% women) for analysis. The median follow-up duration was 3.7 years, with 31,922 cases of incident CKD. Compared with individuals without NAFLD, unadjusted models showed that NAFLD was associated with a higher risk of CKD (RR 1.54, 95% CI 1.38–1.71). After adjusting for multiple cardio-renal risk factors, the CKD risk was still significantly increased in patients with NAFLD (RR 1.39, 95% CI 1.27–1.52). Compared with individuals without NAFLD, the adjusted absolute risk increase in NAFLD for CKD was 5.1 (95% CI 3.5–6.8) per 1000 person-years. Conclusion: NAFLD is associated with an increased risk of incident CKD independent of established cardio-renal risk factors.

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“…The imbalance of cytokines may contribute to the development of CKD, the increased systematic release of various proinflammatory, procoagulant, profibrogenic, and pro-oxidant factors, such as tumor necrosis factor-α, transforming growth factor-β, C-reactive protein, interleukin-6, plasminogen activator inhibitor-1, and connective tissue growth factor (produced by hepatic stellate cells and Kupffer cells from the steatosis liver), may play significant roles in CKD occurrence. [83][84][85]…”

Section: Inflammatory Cytokinesmentioning

confidence: 99%

Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

Tao¹,

Li²,

Cheng³

et al. 2021

J Clin Transl Hepatol

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Nonalcoholic fatty liver disease (NAFLD) is reported to affect 20-30% of adults and is accompanied by various metabolic comorbidities, where the economic and clinical burden of NAFLD is attributed to the progression of liver disease as well as the presence of extrahepatic diseases. Chronic kidney disease (CKD), which has a high incidence rate, high morbidity and mortality rates, and high medical costs, has been linked to NAFLD. CKD is associated with some metabolism-related risk factors that overlap with metabolic comorbidities of NAFLD. Therefore, to investigate the potential factors that influence CKD occurrence, the association between NAFLD and CKD should be clarified. Some studies have confirmed that NAFLD influences the occurrence and severity of CKD, whereas some studies have indicated that there is no correlation. In this review, the results of a few studies have been discussed, the potential risk factors for CKD in NAFLD are explored, and the respective biological mechanisms are elaborated to help clinicians identify CKD in patients much earlier than it is diagnosed now and thus help in reducing the incidence of liver and kidney transplants.

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A brief review on the rising incidence of chronic kidney diseases and non-alcoholic fatty liver disease

Cited by 12 publications

References 37 publications

Evolution of Procedure Indication and Cardiovascular Risk in Transvenous Lead Extraction

Evolution of Procedure Indication and Cardiovascular Risk in Transvenous Lead Extraction

Non-alcoholic fatty liver disease is associated with increased risk of chronic kidney disease

Influence of Nonalcoholic Fatty Liver Disease on the Occurrence and Severity of Chronic Kidney Disease

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